STRINGSTRING
PTPN11 PTPN11 MAPK12 MAPK12 RPS6KB1 RPS6KB1 ZAP70 ZAP70 MAP2K6 MAP2K6 IFNG IFNG NFKBIE NFKBIE IFNGR2 IFNGR2 PIK3CB PIK3CB CD4 CD4 PTPN6 PTPN6 KRAS KRAS MYD88 MYD88 BATF2 BATF2 PIK3CA PIK3CA PIK3R2 PIK3R2 CD28 CD28 G1R620_NOMLE G1R620_NOMLE CD3G CD3G PDCD1 PDCD1 HRAS HRAS JAK2 JAK2 MAPK13 MAPK13 CD274 CD274 CSNK2A1 CSNK2A1 RASGRP1 RASGRP1 STAT3 STAT3 TICAM2 TICAM2 PRKCQ PRKCQ PTEN PTEN IKBKB IKBKB TICAM1 TICAM1 NFKB1 NFKB1 IKBKG IKBKG CD247 CD247 JAK1 JAK1 PPP3CC PPP3CC BATF BATF EGF EGF EML4 EML4 TRAF6 TRAF6 TLR2 TLR2 AKT3 AKT3 RAF1 RAF1 MAPK14 MAPK14 TLR4 TLR4 CHUK CHUK PPP3R1 PPP3R1 PPP3CB PPP3CB MAPK1 MAPK1 AKT1 AKT1 PPP3CA PPP3CA PIK3R1 PIK3R1 MTOR MTOR LOC100605369 LOC100605369 NFATC2 NFATC2 EGFR EGFR MAP2K1 MAP2K1 RELA RELA IFNGR1 IFNGR1 NFATC1 NFATC1 NRAS NRAS CD3E CD3E TIRAP TIRAP NFATC3 NFATC3 PIK3R3 PIK3R3 FOS FOS HIF1A HIF1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
MAPK12Mitogen-activated protein kinase. (368 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (513 aa)
ZAP70Tyrosine-protein kinase. (704 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
NFKBIENFKB inhibitor epsilon. (487 aa)
IFNGR2Interferon gamma receptor 2. (314 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
CD4CD4 molecule. (458 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (627 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (317 aa)
BATF2Basic leucine zipper ATF-like transcription factor 2. (274 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
CD28CD28 molecule. (220 aa)
G1R620_NOMLETIR domain-containing protein. (1031 aa)
CD3GCD3g molecule. (182 aa)
PDCD1Programmed cell death 1. (288 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CD274CD274 molecule. (290 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
RASGRP1RAS guanyl releasing protein 1. (785 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
TICAM2Toll like receptor adaptor molecule 2. (234 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (691 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
IKBKGNEMO domain-containing protein. (173 aa)
CD247CD247 molecule. (163 aa)
JAK1Tyrosine-protein kinase. (1149 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
EML4EMAP like 4. (991 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
TLR2Toll-like receptor. (784 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (832 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (743 aa)
PPP3R1Uncharacterized protein. (189 aa)
PPP3CBSerine/threonine-protein phosphatase. (408 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
LOC100605369Uncharacterized protein. (571 aa)
NFATC2Nuclear factor of activated T cells 2. (905 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
NFATC1Nuclear factor of activated T cells 1. (968 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CD3ECD3e molecule. (198 aa)
TIRAPTIR domain containing adaptor protein. (221 aa)
NFATC3Nuclear factor of activated T cells 3. (1045 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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