STRINGSTRING
ITGA2B ITGA2B MAPK12 MAPK12 EDN1 EDN1 ACVR1 ACVR1 MAP2K7 MAP2K7 MMP2 MMP2 SQSTM1 SQSTM1 MAP2K6 MAP2K6 LOC100589494 LOC100589494 GSTM4 GSTM4 IFNG IFNG GSTA4 GSTA4 GSTA3 GSTA3 GSTA1 GSTA1 CAV3 CAV3 NOS3 NOS3 MGST1 MGST1 PIK3CB PIK3CB ACVR2B ACVR2B CTSL CTSL KLF2 KLF2 PIK3CA PIK3CA CTNNB1 CTNNB1 PIK3R2 PIK3R2 HSP90B1 HSP90B1 SDC4 SDC4 RHOA RHOA MMP9 MMP9 PDGFA PDGFA MAPK7 MAPK7 MAPK13 MAPK13 ACVR2A ACVR2A CAV2 CAV2 VCAM1 VCAM1 ICAM1 ICAM1 KEAP1 KEAP1 ASS1 ASS1 BMP4 BMP4 IKBKB IKBKB MAP2K5 MAP2K5 CALML4 CALML4 NFKB1 NFKB1 MAP3K7 MAP3K7 BMPR1B BMPR1B IKBKG IKBKG IL1R2 IL1R2 PRKAA2 PRKAA2 PECAM1 PECAM1 PDGFB PDGFB GSTO1 GSTO1 NCF2 NCF2 G1SAI6_NOMLE G1SAI6_NOMLE ACTG1 ACTG1 IL1R1 IL1R1 AKT3 AKT3 MAPK14 MAPK14 GSTM1 GSTM1 MEF2A MEF2A BMPR1A BMPR1A CHUK CHUK GSTO2 GSTO2 LOC100602080 LOC100602080 ENSNLEP00000025820 ENSNLEP00000025820 HSP90AA1 HSP90AA1 MAPK10 MAPK10 MAP2K4 MAP2K4 ENSNLEP00000026459 ENSNLEP00000026459 CALML3 CALML3 AKT1 AKT1 ARHGEF2 ARHGEF2 PLAT PLAT SDC2 SDC2 CALM1 CALM1 TNFRSF1A TNFRSF1A MAPK9 MAPK9 PIK3R1 PIK3R1 CAV1 CAV1 ITGB3 ITGB3 THBD THBD GSTA5 GSTA5 PRKAA1 PRKAA1 LOC100595437 LOC100595437 RELA RELA BCL2 BCL2 GSTM3 GSTM3 ENSNLEP00000037515 ENSNLEP00000037515 SELE SELE MGST2 MGST2 SUMO2 SUMO2 NOX1 NOX1 LOC100582253 LOC100582253 BMPR2 BMPR2 RAC2 RAC2 NFE2L2 NFE2L2 KDR KDR IL1B IL1B MGST3 MGST3 HMOX1 HMOX1 PIK3R3 PIK3R3 LOC100604768 LOC100604768 MAPK8 MAPK8 ENSNLEP00000046292 ENSNLEP00000046292 FOS FOS TNF TNF LOC100603153 LOC100603153 MAP3K5 MAP3K5 LOC100595279 LOC100595279
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1040 aa)
MAPK12Mitogen-activated protein kinase. (368 aa)
EDN1Endothelin 1. (211 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (391 aa)
MMP2Matrix metallopeptidase 2. (647 aa)
SQSTM1UBA_5 domain-containing protein. (197 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
LOC100589494Uncharacterized protein; Belongs to the GST superfamily. (244 aa)
GSTM4Glutathione S-transferase mu 4; Belongs to the GST superfamily. (218 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
GSTA4Glutathione S-transferase alpha 4; Belongs to the GST superfamily. (222 aa)
GSTA3Glutathione S-transferase alpha 3; Belongs to the GST superfamily. (222 aa)
GSTA1Glutathione S-transferase alpha 1. (222 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
KLF2Kruppel like factor 2. (355 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
CTNNB1Catenin beta 1. (781 aa)
PIK3R2Uncharacterized protein. (727 aa)
HSP90B1Heat shock protein 90 beta family member 1. (804 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa)
RHOARas homolog family member A. (193 aa)
MMP9Matrix metallopeptidase 9. (692 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (86 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
ICAM1Intercellular adhesion molecule 1. (531 aa)
KEAP1BTB domain-containing protein. (395 aa)
ASS1Uncharacterized protein. (412 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (414 aa)
CALML4Calmodulin like 4. (196 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
IKBKGNEMO domain-containing protein. (173 aa)
IL1R2Interleukin 1 receptor type 2. (398 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (721 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (233 aa)
GSTO1Glutathione S-transferase omega 1. (241 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
G1SAI6_NOMLESmall ubiquitin-related modifier. (100 aa)
ACTG1Actin gamma 1. (378 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
GSTM1Glutathione S-transferase. (189 aa)
MEF2AMyocyte enhancer factor 2A. (509 aa)
BMPR1ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (743 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (243 aa)
LOC100602080Rad60-SLD domain-containing protein. (74 aa)
ENSNLEP00000025820Rad60-SLD domain-containing protein. (80 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (853 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
ENSNLEP00000026459GST N-terminal domain-containing protein. (67 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (806 aa)
THBDThrombomodulin. (568 aa)
GSTA5Glutathione S-transferase alpha 5; Belongs to the GST superfamily. (222 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
LOC100595437Thioredoxin domain-containing protein. (105 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
GSTM3Glutathione S-transferase. (225 aa)
ENSNLEP00000037515Thioredoxin; Belongs to the thioredoxin family. (105 aa)
SELESelectin E. (612 aa)
MGST2Microsomal glutathione S-transferase 2. (147 aa)
SUMO2Small ubiquitin-related modifier. (95 aa)
NOX1NADPH oxidase 1. (564 aa)
LOC100582253Uncharacterized protein. (240 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
RAC2Rac family small GTPase 2. (192 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (607 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
MGST3Microsomal glutathione S-transferase 3. (165 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
LOC100604768Uncharacterized protein. (72 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ENSNLEP00000046292Rad60-SLD domain-containing protein. (63 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC100603153Uncharacterized protein. (445 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1347 aa)
LOC100595279Uncharacterized protein. (212 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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