(51 nodes) HDR through Single Strand Annealing (SSA), and Fanconi anemia pathway network (Opisthorchis viverrini)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T265_15689	Helicase ATP-binding domain-containing protein. (874 aa)
	T265_09785	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (791 aa)
	T265_09792	Chromo_2 domain-containing protein. (593 aa)
	T265_09294	ATP-dependent DNA helicase; Belongs to the helicase family. (579 aa)
	T265_08929	Uncharacterized protein. (1139 aa)
	T265_08769	Uncharacterized protein. (1161 aa)
	T265_09518	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (650 aa)
	T265_11217	Uncharacterized protein. (91 aa)
	T265_14751	RPA_C domain-containing protein. (261 aa)
	T265_07578	Uncharacterized protein. (507 aa)
	T265_10699	XPGI domain-containing protein. (772 aa)
	T265_06534	Uncharacterized protein. (1442 aa)
	T265_14187	Uncharacterized protein. (831 aa)
	T265_05628	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (815 aa)
	T265_05138	Uncharacterized protein. (564 aa)
	T265_04851	Uncharacterized protein. (367 aa)
	T265_13940	Uncharacterized protein. (2358 aa)
	T265_07576	UmuC domain-containing protein. (435 aa)
	T265_13071	Uncharacterized protein. (459 aa)
	T265_02897	UmuC domain-containing protein. (822 aa)
	T265_13304	AAA domain-containing protein. (339 aa)
	T265_02098	Uncharacterized protein. (493 aa)
	T265_11489	AAA domain-containing protein. (337 aa)
	T265_02109	Uncharacterized protein. (126 aa)
	T265_02531	Uncharacterized protein. (198 aa)
	T265_02097	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2379 aa)
	T265_02110	Replication factor C subunit 1. (1093 aa)
	T265_02041	Uncharacterized protein. (1310 aa)
	T265_00786	Zinc-hook domain-containing protein. (1376 aa)
	T265_01582	Uncharacterized protein. (533 aa)
	T265_00612	Uncharacterized protein. (1216 aa)
	T265_03367	Uncharacterized protein. (176 aa)
	T265_12528	Uncharacterized protein. (1533 aa)
	T265_00147	Uncharacterized protein. (235 aa)
	T265_01035	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (365 aa)
	T265_09161	Uncharacterized protein. (964 aa)
	T265_00453	Uncharacterized protein. (1934 aa)
	T265_00347	Uncharacterized protein. (1449 aa)
	T265_02287	Uncharacterized protein. (1570 aa)
	T265_02061	BRCT domain-containing protein. (1151 aa)
	T265_01639	DNA polymerase. (1998 aa)
	T265_01429	AAA domain-containing protein. (1033 aa)
	T265_00948	Uncharacterized protein. (665 aa)
	T265_07023	ANK_REP_REGION domain-containing protein. (1355 aa)
	T265_00205	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (3232 aa)
	T265_06122	NIBRIN_BRCT_II domain-containing protein. (720 aa)
	T265_05919	PWWP domain-containing protein. (1407 aa)
	T265_13854	Uncharacterized protein. (1592 aa)
	T265_05396	RMI1_N domain-containing protein. (582 aa)
	T265_12604	Uncharacterized protein. (1267 aa)
	T265_12513	RECA_2 domain-containing protein. (382 aa)

Your Current Organism:

Opisthorchis viverrini

NCBI taxonomy Id: 6198
Other names: O. viverrini, Southeast Asian liver fluke

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T265_00147	T265_00205	A0A075A3Q3	A0A075AD54	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.565
T265_00147	T265_00453	A0A075A3Q3	A0A075A637	Uncharacterized protein.	Uncharacterized protein.	0.826
T265_00147	T265_00612	A0A075A3Q3	A0A075A2A2	Uncharacterized protein.	Uncharacterized protein.	0.573
T265_00147	T265_00786	A0A075A3Q3	A0A075A0Q4	Uncharacterized protein.	Zinc-hook domain-containing protein.	0.659
T265_00147	T265_01035	A0A075A3Q3	A0A075A3T3	Uncharacterized protein.	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily.	0.898
T265_00147	T265_01582	A0A075A3Q3	A0A075A280	Uncharacterized protein.	Uncharacterized protein.	0.511
T265_00147	T265_01639	A0A075A3Q3	A0A075A921	Uncharacterized protein.	DNA polymerase.	0.401
T265_00147	T265_02041	A0A075A3Q3	A0A075A0P3	Uncharacterized protein.	Uncharacterized protein.	0.622
T265_00147	T265_02897	A0A075A3Q3	A0A074ZUG3	Uncharacterized protein.	UmuC domain-containing protein.	0.439
T265_00147	T265_04851	A0A075A3Q3	A0A074ZLM1	Uncharacterized protein.	Uncharacterized protein.	0.487
T265_00147	T265_05138	A0A075A3Q3	A0A074ZKS2	Uncharacterized protein.	Uncharacterized protein.	0.479
T265_00147	T265_05396	A0A075A3Q3	A0A075AFC4	Uncharacterized protein.	RMI1_N domain-containing protein.	0.615
T265_00147	T265_05628	A0A075A3Q3	A0A074ZIZ6	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.791
T265_00147	T265_05919	A0A075A3Q3	A0A075AEP8	Uncharacterized protein.	PWWP domain-containing protein.	0.565
T265_00147	T265_06122	A0A075A3Q3	A0A075AEG4	Uncharacterized protein.	NIBRIN_BRCT_II domain-containing protein.	0.657
T265_00147	T265_06534	A0A075A3Q3	A0A074ZG74	Uncharacterized protein.	Uncharacterized protein.	0.808
T265_00147	T265_08769	A0A075A3Q3	A0A074Z7Y8	Uncharacterized protein.	Uncharacterized protein.	0.546
T265_00147	T265_08929	A0A075A3Q3	A0A074Z7F7	Uncharacterized protein.	Uncharacterized protein.	0.573
T265_00147	T265_09161	A0A075A3Q3	A0A075A5V6	Uncharacterized protein.	Uncharacterized protein.	0.513
T265_00147	T265_09518	A0A075A3Q3	A0A074Z9X4	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.511