(25 nodes) Homologous DNA Pairing and Strand Exchange, and Fanconi Anemia Pathway network (Opisthorchis viverrini)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T265_09785	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (791 aa)
	T265_08929	Uncharacterized protein. (1139 aa)
	T265_09518	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (650 aa)
	T265_14751	RPA_C domain-containing protein. (261 aa)
	T265_06534	Uncharacterized protein. (1442 aa)
	T265_14187	Uncharacterized protein. (831 aa)
	T265_05628	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (815 aa)
	T265_02098	Uncharacterized protein. (493 aa)
	T265_02097	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2379 aa)
	T265_02041	Uncharacterized protein. (1310 aa)
	T265_00786	Zinc-hook domain-containing protein. (1376 aa)
	T265_01582	Uncharacterized protein. (533 aa)
	T265_12528	Uncharacterized protein. (1533 aa)
	T265_00147	Uncharacterized protein. (235 aa)
	T265_01035	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (365 aa)
	T265_09161	Uncharacterized protein. (964 aa)
	T265_00453	Uncharacterized protein. (1934 aa)
	T265_00948	Uncharacterized protein. (665 aa)
	T265_00205	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (3232 aa)
	T265_06122	NIBRIN_BRCT_II domain-containing protein. (720 aa)
	T265_05919	PWWP domain-containing protein. (1407 aa)
	T265_13854	Uncharacterized protein. (1592 aa)
	T265_05396	RMI1_N domain-containing protein. (582 aa)
	T265_12604	Uncharacterized protein. (1267 aa)
	T265_12513	RECA_2 domain-containing protein. (382 aa)

Your Current Organism:

Opisthorchis viverrini

NCBI taxonomy Id: 6198
Other names: O. viverrini, Southeast Asian liver fluke

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T265_00147	T265_00205	A0A075A3Q3	A0A075AD54	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.565
T265_00147	T265_00453	A0A075A3Q3	A0A075A637	Uncharacterized protein.	Uncharacterized protein.	0.826
T265_00147	T265_00786	A0A075A3Q3	A0A075A0Q4	Uncharacterized protein.	Zinc-hook domain-containing protein.	0.659
T265_00147	T265_01035	A0A075A3Q3	A0A075A3T3	Uncharacterized protein.	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily.	0.898
T265_00147	T265_01582	A0A075A3Q3	A0A075A280	Uncharacterized protein.	Uncharacterized protein.	0.511
T265_00147	T265_02041	A0A075A3Q3	A0A075A0P3	Uncharacterized protein.	Uncharacterized protein.	0.622
T265_00147	T265_05396	A0A075A3Q3	A0A075AFC4	Uncharacterized protein.	RMI1_N domain-containing protein.	0.615
T265_00147	T265_05628	A0A075A3Q3	A0A074ZIZ6	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.791
T265_00147	T265_05919	A0A075A3Q3	A0A075AEP8	Uncharacterized protein.	PWWP domain-containing protein.	0.565
T265_00147	T265_06122	A0A075A3Q3	A0A075AEG4	Uncharacterized protein.	NIBRIN_BRCT_II domain-containing protein.	0.657
T265_00147	T265_06534	A0A075A3Q3	A0A074ZG74	Uncharacterized protein.	Uncharacterized protein.	0.808
T265_00147	T265_08929	A0A075A3Q3	A0A074Z7F7	Uncharacterized protein.	Uncharacterized protein.	0.573
T265_00147	T265_09161	A0A075A3Q3	A0A075A5V6	Uncharacterized protein.	Uncharacterized protein.	0.513
T265_00147	T265_09518	A0A075A3Q3	A0A074Z9X4	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.511
T265_00147	T265_09785	A0A075A3Q3	A0A074Z4L6	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.474
T265_00147	T265_12513	A0A075A3Q3	A0A075AJS0	Uncharacterized protein.	RECA_2 domain-containing protein.	0.898
T265_00147	T265_12528	A0A075A3Q3	A0A075A3L2	Uncharacterized protein.	Uncharacterized protein.	0.663
T265_00147	T265_12604	A0A075A3Q3	A0A075AJL1	Uncharacterized protein.	Uncharacterized protein.	0.519
T265_00147	T265_13854	A0A075A3Q3	A0A075AEX4	Uncharacterized protein.	Uncharacterized protein.	0.599
T265_00147	T265_14187	A0A075A3Q3	A0A074ZIH0	Uncharacterized protein.	Uncharacterized protein.	0.948