(45 nodes) RHO GTPases Activate WASPs and WAVEs, and Actin family network (Opisthorchis viverrini)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T265_16249	Uncharacterized protein; Belongs to the actin family. (183 aa)
	T265_11026	Uncharacterized protein. (153 aa)
	T265_11088	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (136 aa)
	T265_15320	Uncharacterized protein; Belongs to the actin family. (376 aa)
	T265_11027	Uncharacterized protein. (246 aa)
	T265_09602	Uncharacterized protein; Belongs to the actin family. (372 aa)
	T265_15982	Uncharacterized protein. (107 aa)
	T265_09499	Actin. (376 aa)
	T265_11974	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (250 aa)
	T265_11759	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (156 aa)
	T265_09603	Uncharacterized protein. (361 aa)
	T265_09441	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (315 aa)
	T265_11175	Reverse transcriptase domain-containing protein. (979 aa)
	T265_10515	Uncharacterized protein. (165 aa)
	T265_14210	Uncharacterized protein; Belongs to the actin family. (421 aa)
	T265_06996	Uncharacterized protein. (1306 aa)
	T265_07910	Calponin-homology (CH) domain-containing protein. (508 aa)
	T265_06409	WH2 domain-containing protein. (199 aa)
	T265_07140	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (361 aa)
	T265_06755	Uncharacterized protein. (513 aa)
	T265_14624	SH3 domain-containing protein. (926 aa)
	T265_07466	Uncharacterized protein; Belongs to the actin family. (765 aa)
	T265_07205	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (405 aa)
	T265_03429	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (510 aa)
	T265_03036	Transgelin; Belongs to the calponin family. (190 aa)
	T265_04993	CAP_N domain-containing protein. (384 aa)
	T265_11028	Uncharacterized protein. (358 aa)
	T265_02321	Uncharacterized protein. (3063 aa)
	T265_02272	Reverse transcriptase domain-containing protein. (303 aa)
	T265_01131	Uncharacterized protein. (2543 aa)
	T265_12731	ADF-H domain-containing protein. (317 aa)
	T265_10519	Uncharacterized protein. (619 aa)
	T265_13369	Uncharacterized protein. (429 aa)
	T265_10134	WD_REPEATS_REGION domain-containing protein. (502 aa)
	T265_01136	SH3 domain-containing protein. (597 aa)
	T265_09443	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (298 aa)
	T265_01327	Adenylyl cyclase-associated protein; Belongs to the CAP family. (522 aa)
	T265_00572	Actin. (376 aa)
	T265_12580	Uncharacterized protein. (166 aa)
	T265_13745	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1323 aa)
	T265_02343	Uncharacterized protein. (648 aa)
	T265_01190	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (381 aa)
	T265_00654	Uncharacterized protein. (553 aa)
	T265_00571	Uncharacterized protein. (376 aa)
	T265_00153	Uncharacterized protein. (892 aa)

Your Current Organism:

Opisthorchis viverrini

NCBI taxonomy Id: 6198
Other names: O. viverrini, Southeast Asian liver fluke

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T265_00153	T265_00571	A0A075AK08	A0A075AJN4	Uncharacterized protein.	Uncharacterized protein.	0.412
T265_00153	T265_00572	A0A075AK08	A0A075ACN7	Uncharacterized protein.	Actin.	0.412
T265_00153	T265_01327	A0A075AK08	A0A075AA54	Uncharacterized protein.	Adenylyl cyclase-associated protein; Belongs to the CAP family.	0.492
T265_00153	T265_03036	A0A075AK08	A0A074ZTW2	Uncharacterized protein.	Transgelin; Belongs to the calponin family.	0.568
T265_00153	T265_04993	A0A075AK08	A0A074ZXK4	Uncharacterized protein.	CAP_N domain-containing protein.	0.408
T265_00153	T265_06755	A0A075AK08	A0A074ZJE3	Uncharacterized protein.	Uncharacterized protein.	0.564
T265_00153	T265_07140	A0A075AK08	A0A074ZHZ2	Uncharacterized protein.	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.	0.463
T265_00153	T265_07205	A0A075AK08	A0A074ZPT1	Uncharacterized protein.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.537
T265_00153	T265_07910	A0A075AK08	A0A074ZFM0	Uncharacterized protein.	Calponin-homology (CH) domain-containing protein.	0.463
T265_00153	T265_09499	A0A075AK08	A0A074Z5L1	Uncharacterized protein.	Actin.	0.412
T265_00153	T265_09602	A0A075AK08	A0A074Z581	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.412
T265_00153	T265_09603	A0A075AK08	A0A074Z9N4	Uncharacterized protein.	Uncharacterized protein.	0.412
T265_00153	T265_10134	A0A075AK08	A0A075A2E2	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.443
T265_00153	T265_11027	A0A075AK08	A0A074Z4H2	Uncharacterized protein.	Uncharacterized protein.	0.412
T265_00153	T265_11028	A0A075AK08	A0A074ZZ09	Uncharacterized protein.	Uncharacterized protein.	0.412
T265_00153	T265_11759	A0A075AK08	A0A074Z8C5	Uncharacterized protein.	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.	0.568
T265_00153	T265_11974	A0A075AK08	A0A074Z7J1	Uncharacterized protein.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.537
T265_00153	T265_12731	A0A075AK08	A0A075A0J8	Uncharacterized protein.	ADF-H domain-containing protein.	0.633
T265_00153	T265_13369	A0A075AK08	A0A075A1E7	Uncharacterized protein.	Uncharacterized protein.	0.712
T265_00153	T265_14210	A0A075AK08	A0A074ZDW9	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.642