(33 nodes) Telomere maintenance network (Opisthorchis viverrini)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T265_09518	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (650 aa)
	T265_14187	Uncharacterized protein. (831 aa)
	T265_05628	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (815 aa)
	T265_13978	Uncharacterized protein. (2777 aa)
	T265_01035	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (365 aa)
	T265_07445	Ku domain-containing protein. (1284 aa)
	T265_03453	Poly [ADP-ribose] polymerase. (402 aa)
	T265_02098	Uncharacterized protein. (493 aa)
	T265_02103	PI3K/PI4K domain-containing protein. (4230 aa)
	T265_02097	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2379 aa)
	T265_00786	Zinc-hook domain-containing protein. (1376 aa)
	T265_02061	BRCT domain-containing protein. (1151 aa)
	T265_01862	DUF3504 domain-containing protein. (902 aa)
	T265_00205	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (3232 aa)
	T265_06122	NIBRIN_BRCT_II domain-containing protein. (720 aa)
	T265_06086	DRMBL domain-containing protein. (283 aa)
	T265_05703	NFRKB_winged domain-containing protein. (544 aa)
	T265_04495	Ku domain-containing protein. (974 aa)
	T265_12513	RECA_2 domain-containing protein. (382 aa)
	T265_01915	Uncharacterized protein. (709 aa)
	T265_00612	Uncharacterized protein. (1216 aa)
	T265_00630	Uncharacterized protein. (3231 aa)
	T265_10980	Uncharacterized protein. (1014 aa)
	T265_15873	Telo_bind domain-containing protein. (110 aa)
	T265_15623	Telo_bind domain-containing protein. (725 aa)
	T265_15689	Helicase ATP-binding domain-containing protein. (874 aa)
	T265_14481	G-patch domain-containing protein. (290 aa)
	T265_08769	Uncharacterized protein. (1161 aa)
	T265_09294	ATP-dependent DNA helicase; Belongs to the helicase family. (579 aa)
	T265_15060	FHA domain-containing protein. (690 aa)
	T265_11437	DUF4550 domain-containing protein. (878 aa)
	T265_10398	Uncharacterized protein. (2023 aa)
	T265_07016	DRMBL domain-containing protein. (471 aa)

Your Current Organism:

Opisthorchis viverrini

NCBI taxonomy Id: 6198
Other names: O. viverrini, Southeast Asian liver fluke

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T265_00205	T265_00612	A0A075AD54	A0A075A2A2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.883
T265_00205	T265_00786	A0A075AD54	A0A075A0Q4	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Zinc-hook domain-containing protein.	0.973
T265_00205	T265_01035	A0A075AD54	A0A075A3T3	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily.	0.932
T265_00205	T265_02061	A0A075AD54	A0A075A815	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	BRCT domain-containing protein.	0.771
T265_00205	T265_02097	A0A075AD54	A0A075A0G4	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.960
T265_00205	T265_02098	A0A075AD54	A0A074ZWB3	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.960
T265_00205	T265_02103	A0A075AD54	A0A074ZWB6	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	PI3K/PI4K domain-containing protein.	0.698
T265_00205	T265_04495	A0A075AD54	A0A075AGG9	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Ku domain-containing protein.	0.917
T265_00205	T265_05628	A0A075AD54	A0A074ZIZ6	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.986
T265_00205	T265_06086	A0A075AD54	A0A075AEH6	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	DRMBL domain-containing protein.	0.482
T265_00205	T265_06122	A0A075AD54	A0A075AEG4	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	NIBRIN_BRCT_II domain-containing protein.	0.989
T265_00205	T265_07016	A0A075AD54	A0A074ZID3	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	DRMBL domain-containing protein.	0.482
T265_00205	T265_07445	A0A075AD54	A0A074ZNT4	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Ku domain-containing protein.	0.936
T265_00205	T265_08769	A0A075AD54	A0A074Z7Y8	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.704
T265_00205	T265_09294	A0A075AD54	A0A074Z6B8	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	ATP-dependent DNA helicase; Belongs to the helicase family.	0.479
T265_00205	T265_09518	A0A075AD54	A0A074Z9X4	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.874
T265_00205	T265_10980	A0A075AD54	A0A074Z0K1	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.497
T265_00205	T265_12513	A0A075AD54	A0A075AJS0	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	RECA_2 domain-containing protein.	0.820
T265_00205	T265_14187	A0A075AD54	A0A074ZIH0	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.825
T265_00205	T265_15689	A0A075AD54	A0A074YWI6	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Helicase ATP-binding domain-containing protein.	0.704