(111 nodes) Actin cytoskeleton network (Opisthorchis viverrini)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T265_01190	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (381 aa)
	T265_00811	Uncharacterized protein. (516 aa)
	T265_00461	PDZ domain-containing protein. (521 aa)
	T265_00284	Myosin_tail_1 domain-containing protein. (871 aa)
	T265_00153	Uncharacterized protein. (892 aa)
	T265_07205	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (405 aa)
	T265_03834	Uncharacterized protein. (801 aa)
	T265_07042	Myosin_tail_1 domain-containing protein. (934 aa)
	T265_04656	Uncharacterized protein. (2467 aa)
	T265_13299	Uncharacterized protein. (234 aa)
	T265_04494	Uncharacterized protein. (696 aa)
	T265_03429	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (510 aa)
	T265_06345	FH2 domain-containing protein. (335 aa)
	T265_04294	PDZ domain-containing protein. (170 aa)
	T265_02869	Uncharacterized protein. (905 aa)
	T265_15785	Uncharacterized protein. (215 aa)
	T265_02867	Uncharacterized protein. (300 aa)
	T265_13030	Uncharacterized protein. (987 aa)
	T265_02436	Uncharacterized protein. (506 aa)
	T265_03566	Uncharacterized protein. (352 aa)
	T265_11810	EF hand. (175 aa)
	T265_11727	Uncharacterized protein. (238 aa)
	T265_12961	Uncharacterized protein. (850 aa)
	T265_05089	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (307 aa)
	T265_02114	Uncharacterized protein. (305 aa)
	T265_02762	Uncharacterized protein. (335 aa)
	T265_12962	Calponin-homology (CH) domain-containing protein. (1454 aa)
	T265_04518	Uncharacterized protein. (3031 aa)
	T265_02272	Reverse transcriptase domain-containing protein. (303 aa)
	T265_15248	Ig-like domain-containing protein. (513 aa)
	T265_02233	LLGL domain-containing protein. (1387 aa)
	T265_12731	ADF-H domain-containing protein. (317 aa)
	T265_12597	HP domain-containing protein. (494 aa)
	T265_13369	Uncharacterized protein. (429 aa)
	T265_03906	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (364 aa)
	T265_12571	Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1805 aa)
	T265_10134	WD_REPEATS_REGION domain-containing protein. (502 aa)
	T265_12596	Uncharacterized protein. (384 aa)
	T265_01026	Reverse transcriptase domain-containing protein. (144 aa)
	T265_09443	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (298 aa)
	T265_12616	CTLH domain-containing protein. (475 aa)
	T265_13462	Uncharacterized protein. (954 aa)
	T265_02866	Uncharacterized protein. (230 aa)
	T265_07321	Uncharacterized protein. (393 aa)
	T265_04416	Uncharacterized protein. (474 aa)
	T265_07466	Uncharacterized protein; Belongs to the actin family. (765 aa)
	T265_07818	Uncharacterized protein. (357 aa)
	T265_07991	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2180 aa)
	T265_08098	Uncharacterized protein. (249 aa)
	T265_06755	Uncharacterized protein. (513 aa)
	T265_06747	Uncharacterized protein. (383 aa)
	T265_13925	IMD domain-containing protein. (839 aa)
	T265_08923	Troponin. (364 aa)
	T265_05827	Uncharacterized protein. (326 aa)
	T265_09283	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2152 aa)
	T265_09407	Uncharacterized protein. (1506 aa)
	T265_06453	HP domain-containing protein. (2398 aa)
	T265_14136	Uncharacterized protein. (329 aa)
	T265_06746	Uncharacterized protein. (448 aa)
	T265_06919	Arf-GAP domain-containing protein. (184 aa)
	T265_08345	Calponin-homology (CH) domain-containing protein. (158 aa)
	T265_14210	Uncharacterized protein; Belongs to the actin family. (421 aa)
	T265_10284	Uncharacterized protein. (302 aa)
	T265_14316	Uncharacterized protein. (131 aa)
	T265_14303	Uncharacterized protein. (2198 aa)
	T265_07714	Calponin-homology (CH) domain-containing protein. (1325 aa)
	T265_14769	SWIM-type domain-containing protein. (841 aa)
	T265_14450	Uncharacterized protein. (657 aa)
	T265_11217	Uncharacterized protein. (91 aa)
	T265_08099	Uncharacterized protein. (284 aa)
	T265_09441	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (315 aa)
	T265_08239	PDZ domain-containing protein. (1487 aa)
	T265_08508	Uncharacterized protein. (270 aa)
	T265_11632	PH domain-containing protein. (1305 aa)
	T265_11759	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (156 aa)
	T265_09952	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1932 aa)
	T265_11974	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (250 aa)
	T265_15128	Uncharacterized protein. (1305 aa)
	T265_09362	Uncharacterized protein. (334 aa)
	T265_14840	Uncharacterized protein. (737 aa)
	T265_15982	Uncharacterized protein. (107 aa)
	T265_16012	Uncharacterized protein. (106 aa)
	T265_10957	Drf_GBD domain-containing protein. (187 aa)
	T265_09854	Uncharacterized protein. (279 aa)
	T265_16335	Uncharacterized protein. (90 aa)
	T265_15070	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2147 aa)
	T265_15214	BAG domain-containing protein. (403 aa)
	T265_15672	Uncharacterized protein. (418 aa)
	T265_11088	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (136 aa)
	T265_11086	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (155 aa)
	T265_11218	Uncharacterized protein. (114 aa)
	T265_15860	Uncharacterized protein. (62 aa)
	T265_16008	Uncharacterized protein. (154 aa)
	T265_02614	Uncharacterized protein. (2130 aa)
	T265_00347	Uncharacterized protein. (1449 aa)
	T265_02435	Spectrin beta chain; Belongs to the spectrin family. (2345 aa)
	T265_14722	Uncharacterized protein. (1428 aa)
	T265_02246	PH domain-containing protein. (1257 aa)
	T265_08714	Uncharacterized protein. (295 aa)
	T265_12848	Uncharacterized protein. (290 aa)
	T265_00973	IMD domain-containing protein. (981 aa)
	T265_12695	LIM domain protein. (316 aa)
	T265_00826	Uncharacterized protein. (376 aa)
	T265_07209	Uncharacterized protein. (615 aa)
	T265_12580	Uncharacterized protein. (166 aa)
	T265_13593	PH domain-containing protein. (1193 aa)
	T265_02843	LIM zinc-binding domain-containing protein. (1126 aa)
	T265_13055	Spectrin repeat-containing domain protein. (2421 aa)
	T265_02343	Uncharacterized protein. (648 aa)
	T265_02141	Uncharacterized protein. (449 aa)
	T265_02060	LIM zinc-binding domain-containing protein. (425 aa)

Your Current Organism:

Opisthorchis viverrini

NCBI taxonomy Id: 6198
Other names: O. viverrini, Southeast Asian liver fluke

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T265_00153	T265_03906	A0A075AK08	A0A075A1K5	Uncharacterized protein.	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.476
T265_00153	T265_05089	A0A075AK08	A0A074ZX82	Uncharacterized protein.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.802
T265_00153	T265_06755	A0A075AK08	A0A074ZJE3	Uncharacterized protein.	Uncharacterized protein.	0.564
T265_00153	T265_07205	A0A075AK08	A0A074ZPT1	Uncharacterized protein.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.537
T265_00153	T265_07991	A0A075AK08	A0A074ZLR6	Uncharacterized protein.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.420
T265_00153	T265_09952	A0A075AK08	A0A074Z8A5	Uncharacterized protein.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.420
T265_00153	T265_10134	A0A075AK08	A0A075A2E2	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.443
T265_00153	T265_11759	A0A075AK08	A0A074Z8C5	Uncharacterized protein.	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.	0.568
T265_00153	T265_11974	A0A075AK08	A0A074Z7J1	Uncharacterized protein.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.537
T265_00153	T265_12731	A0A075AK08	A0A075A0J8	Uncharacterized protein.	ADF-H domain-containing protein.	0.633
T265_00153	T265_13299	A0A075AK08	A0A074ZRU9	Uncharacterized protein.	Uncharacterized protein.	0.469
T265_00153	T265_13369	A0A075AK08	A0A075A1E7	Uncharacterized protein.	Uncharacterized protein.	0.712
T265_00153	T265_14210	A0A075AK08	A0A074ZDW9	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.642
T265_00153	T265_15128	A0A075AK08	A0A074Z6U1	Uncharacterized protein.	Uncharacterized protein.	0.459
T265_00284	T265_00461	A0A075AJR2	A0A075AJQ5	Myosin_tail_1 domain-containing protein.	PDZ domain-containing protein.	0.400
T265_00284	T265_02141	A0A075AJR2	A0A075AIH2	Myosin_tail_1 domain-containing protein.	Uncharacterized protein.	0.409
T265_00284	T265_02762	A0A075AJR2	A0A074ZY85	Myosin_tail_1 domain-containing protein.	Uncharacterized protein.	0.643
T265_00284	T265_02866	A0A075AJR2	A0A075A5E9	Myosin_tail_1 domain-containing protein.	Uncharacterized protein.	0.653
T265_00284	T265_02867	A0A075AJR2	A0A074ZUM9	Myosin_tail_1 domain-containing protein.	Uncharacterized protein.	0.653
T265_00284	T265_02869	A0A075AJR2	A0A074ZTG1	Myosin_tail_1 domain-containing protein.	Uncharacterized protein.	0.517