(43 nodes) Carbon-oxygen lyase activity network (Opisthorchis viverrini)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	T265_10377	VWFA domain-containing protein. (317 aa)
	T265_12639	Ribosomal_S3_C domain-containing protein. (94 aa)
	T265_12458	MaoC-like domain-containing protein. (170 aa)
	T265_03260	DUF3421 domain-containing protein. (165 aa)
	T265_04306	Putative 4a-hydroxytetrahydrobiopterin dehydratase. (108 aa)
	T265_03262	Uncharacterized protein. (436 aa)
	T265_15589	Alpha-carbonic anhydrase domain-containing protein. (235 aa)
	T265_13868	Alpha-carbonic anhydrase domain-containing protein. (177 aa)
	T265_13084	Uncharacterized protein. (167 aa)
	T265_14247	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (126 aa)
	T265_07445	Ku domain-containing protein. (1284 aa)
	T265_10585	DJ-1_PfpI domain-containing protein. (210 aa)
	T265_15590	Alpha-carbonic anhydrase domain-containing protein. (228 aa)
	T265_14692	ENDO3c domain-containing protein. (323 aa)
	NTH1	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (976 aa)
	T265_14256	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (729 aa)
	T265_15140	VIT domain-containing protein. (445 aa)
	T265_10327	Uncharacterized protein. (431 aa)
	T265_07100	Uncharacterized protein. (188 aa)
	T265_14007	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (523 aa)
	T265_07006	Uncharacterized protein. (320 aa)
	T265_13867	Alpha-carbonic anhydrase domain-containing protein. (83 aa)
	T265_08883	Uncharacterized protein. (228 aa)
	T265_13772	Uncharacterized protein. (496 aa)
	T265_14550	Fe2OG dioxygenase domain-containing protein. (392 aa)
	T265_11881	Alpha-carbonic anhydrase domain-containing protein; Belongs to the alpha-carbonic anhydrase family. (320 aa)
	T265_11343	Uncharacterized protein. (403 aa)
	T265_15401	DJ-1 family protein. (183 aa)
	T265_11880	Alpha-carbonic anhydrase domain-containing protein; Belongs to the alpha-carbonic anhydrase family. (325 aa)
	T265_07875	Alpha-carbonic anhydrase domain-containing protein; Belongs to the alpha-carbonic anhydrase family. (220 aa)
	T265_15139	Uncharacterized protein. (139 aa)
	T265_00302	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (380 aa)
	T265_01634	Enolase_C domain-containing protein. (507 aa)
	T265_02112	Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (212 aa)
	T265_13333	Uncharacterized protein. (541 aa)
	T265_05795	Uncharacterized protein. (888 aa)
	T265_06847	Putative fumarate hydratase, class II. (494 aa)
	T265_07008	CS domain-containing protein. (145 aa)
	T265_12574	HEM4 domain-containing protein. (253 aa)
	T265_01156	ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. (289 aa)
	T265_12761	Uncharacterized protein. (180 aa)
	T265_08169	Uncharacterized protein. (930 aa)
	T265_13083	Alpha-carbonic anhydrase domain-containing protein. (364 aa)

Your Current Organism:

Opisthorchis viverrini

NCBI taxonomy Id: 6198
Other names: O. viverrini, Southeast Asian liver fluke

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NTH1	T265_08883	A0A074ZD22	A0A074ZIP3	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	Uncharacterized protein.	0.583
NTH1	T265_14692	A0A074ZD22	A0A074ZC93	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	ENDO3c domain-containing protein.	0.583
T265_00302	T265_07100	A0A075AJR7	A0A074ZE20	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Uncharacterized protein.	0.420
T265_00302	T265_08169	A0A075AJR7	A0A075A985	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Uncharacterized protein.	0.437
T265_00302	T265_12458	A0A075AJR7	A0A075A4I4	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	MaoC-like domain-containing protein.	0.602
T265_00302	T265_14256	A0A075AJR7	A0A074ZDF6	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	0.652
T265_01634	T265_03262	A0A075AIT6	A0A074ZWN8	Enolase_C domain-containing protein.	Uncharacterized protein.	0.912
T265_01634	T265_06847	A0A075AIT6	A0A075ACZ8	Enolase_C domain-containing protein.	Putative fumarate hydratase, class II.	0.518
T265_01634	T265_10327	A0A075AIT6	A0A074ZDQ2	Enolase_C domain-containing protein.	Uncharacterized protein.	0.912
T265_01634	T265_12639	A0A075AIT6	A0A075A4U5	Enolase_C domain-containing protein.	Ribosomal_S3_C domain-containing protein.	0.732
T265_01634	T265_14256	A0A075AIT6	A0A074ZDF6	Enolase_C domain-containing protein.	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	0.439
T265_03262	T265_01634	A0A074ZWN8	A0A075AIT6	Uncharacterized protein.	Enolase_C domain-containing protein.	0.912
T265_03262	T265_06847	A0A074ZWN8	A0A075ACZ8	Uncharacterized protein.	Putative fumarate hydratase, class II.	0.554
T265_03262	T265_10327	A0A074ZWN8	A0A074ZDQ2	Uncharacterized protein.	Uncharacterized protein.	0.901
T265_03262	T265_12639	A0A074ZWN8	A0A075A4U5	Uncharacterized protein.	Ribosomal_S3_C domain-containing protein.	0.732
T265_03262	T265_14256	A0A074ZWN8	A0A074ZDF6	Uncharacterized protein.	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	0.501
T265_04306	T265_12761	A0A075A0C9	A0A075AAJ3	Putative 4a-hydroxytetrahydrobiopterin dehydratase.	Uncharacterized protein.	0.569
T265_06847	T265_01634	A0A075ACZ8	A0A075AIT6	Putative fumarate hydratase, class II.	Enolase_C domain-containing protein.	0.518
T265_06847	T265_03262	A0A075ACZ8	A0A074ZWN8	Putative fumarate hydratase, class II.	Uncharacterized protein.	0.554
T265_06847	T265_10327	A0A075ACZ8	A0A074ZDQ2	Putative fumarate hydratase, class II.	Uncharacterized protein.	0.554