(20 nodes) Acid-thiol ligase activity network (Opisthorchis viverrini)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	T265_12743	Uncharacterized protein. (308 aa)
	T265_00432	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (326 aa)
	T265_10168	AMP-binding domain-containing protein. (828 aa)
	T265_01199	ACAS_N domain-containing protein. (381 aa)
	T265_02085	AMP-binding domain-containing protein. (678 aa)
	T265_03080	Uncharacterized protein. (1210 aa)
	T265_03745	Uncharacterized protein. (944 aa)
	T265_14880	Reverse transcriptase domain-containing protein. (991 aa)
	T265_09539	Uncharacterized protein. (554 aa)
	T265_00281	Uncharacterized protein. (702 aa)
	T265_07546	AMP-binding domain-containing protein. (569 aa)
	T265_13191	AMP-binding domain-containing protein. (424 aa)
	T265_16083	AMP-binding domain-containing protein. (87 aa)
	T265_10158	AMP-binding domain-containing protein. (664 aa)
	T265_13783	Succinate-CoA ligase subunit beta. (560 aa)
	T265_03241	Succinate-CoA ligase subunit beta. (373 aa)
	T265_14318	Uncharacterized protein. (685 aa)
	T265_07956	AMP-binding domain-containing protein. (705 aa)
	T265_10291	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (420 aa)
	T265_14738	Uncharacterized protein. (724 aa)

Your Current Organism:

Opisthorchis viverrini

NCBI taxonomy Id: 6198
Other names: O. viverrini, Southeast Asian liver fluke

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T265_00281	T265_00432	A0A075AJR1	A0A075A326	Uncharacterized protein.	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	0.861
T265_00281	T265_03080	A0A075AJR1	A0A074ZX08	Uncharacterized protein.	Uncharacterized protein.	0.522
T265_00281	T265_03241	A0A075AJR1	A0A074ZWL8	Uncharacterized protein.	Succinate-CoA ligase subunit beta.	0.843
T265_00281	T265_09539	A0A075AJR1	A0A075A4J9	Uncharacterized protein.	Uncharacterized protein.	0.912
T265_00281	T265_10291	A0A075AJR1	A0A074ZDT8	Uncharacterized protein.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.843
T265_00281	T265_13783	A0A075AJR1	A0A074ZNZ3	Uncharacterized protein.	Succinate-CoA ligase subunit beta.	0.843
T265_00281	T265_14880	A0A075AJR1	A0A074Z5D9	Uncharacterized protein.	Reverse transcriptase domain-containing protein.	0.912
T265_00432	T265_00281	A0A075A326	A0A075AJR1	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	Uncharacterized protein.	0.861
T265_00432	T265_03241	A0A075A326	A0A074ZWL8	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	Succinate-CoA ligase subunit beta.	0.999
T265_00432	T265_03745	A0A075A326	A0A075AHE2	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	Uncharacterized protein.	0.440
T265_00432	T265_10291	A0A075A326	A0A074ZDT8	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.999
T265_00432	T265_13783	A0A075A326	A0A074ZNZ3	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	Succinate-CoA ligase subunit beta.	0.999
T265_01199	T265_03080	A0A074ZZ47	A0A074ZX08	ACAS_N domain-containing protein.	Uncharacterized protein.	0.522
T265_01199	T265_12743	A0A074ZZ47	A0A075A396	ACAS_N domain-containing protein.	Uncharacterized protein.	0.632
T265_02085	T265_03080	A0A074ZXB5	A0A074ZX08	AMP-binding domain-containing protein.	Uncharacterized protein.	0.474
T265_02085	T265_03745	A0A074ZXB5	A0A075AHE2	AMP-binding domain-containing protein.	Uncharacterized protein.	0.794
T265_02085	T265_07546	A0A074ZXB5	A0A075AB73	AMP-binding domain-containing protein.	AMP-binding domain-containing protein.	0.638
T265_02085	T265_07956	A0A074ZXB5	A0A074ZFE0	AMP-binding domain-containing protein.	AMP-binding domain-containing protein.	0.628
T265_02085	T265_13191	A0A074ZXB5	A0A074ZTE2	AMP-binding domain-containing protein.	AMP-binding domain-containing protein.	0.642
T265_02085	T265_14318	A0A074ZXB5	A0A074ZNF6	AMP-binding domain-containing protein.	Uncharacterized protein.	0.637