(65 nodes) Cellular respiration network (Opisthorchis viverrini)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T265_07712	Uncharacterized protein. (200 aa)
	T265_07717	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (369 aa)
	T265_07323	Uncharacterized protein. (165 aa)
	T265_07189	Uncharacterized protein. (254 aa)
	T265_06847	Putative fumarate hydratase, class II. (494 aa)
	T265_06605	Uncharacterized protein. (522 aa)
	T265_05723	Uncharacterized protein. (137 aa)
	T265_05624	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (547 aa)
	T265_04596	NADH:ubiquinone oxidoreductase subunit B14.5a. (114 aa)
	T265_13353	Ldh_1_C domain-containing protein. (530 aa)
	T265_01077	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (278 aa)
	T265_01598	Uncharacterized protein. (258 aa)
	T265_01732	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (522 aa)
	T265_01971	Uncharacterized protein. (63 aa)
	T265_09199	Cytochrome c domain-containing protein. (374 aa)
	T265_09475	Complex1_49kDa domain-containing protein; Belongs to the complex I 49 kDa subunit family. (573 aa)
	T265_00964	Uncharacterized protein. (353 aa)
	T265_00432	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (326 aa)
	T265_01787	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (991 aa)
	T265_10305	Oxidored_q6 domain-containing protein; Belongs to the complex I 20 kDa subunit family. (132 aa)
	T265_04260	Malate dehydrogenase. (284 aa)
	T265_02102	Ubiquinol-cytochrome C reductase hinge protein. (113 aa)
	T265_04624	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (586 aa)
	T265_02546	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (397 aa)
	T265_12805	Uncharacterized protein. (864 aa)
	T265_01591	Uncharacterized protein. (432 aa)
	T265_11550	Cytochrome c oxidase subunit Va. (157 aa)
	T265_03241	Succinate-CoA ligase subunit beta. (373 aa)
	T265_15668	Uncharacterized protein. (674 aa)
	T265_03074	Uncharacterized protein. (247 aa)
	T265_16243	Malate dehydrogenase. (113 aa)
	T265_03698	ETF domain-containing protein. (260 aa)
	T265_13621	CIA30 domain-containing protein. (373 aa)
	T265_03687	zf-CHCC domain-containing protein. (231 aa)
	T265_06956	Uncharacterized protein. (156 aa)
	T265_07402	dNK domain-containing protein. (418 aa)
	T265_13783	Succinate-CoA ligase subunit beta. (560 aa)
	T265_13500	Uncharacterized protein. (1013 aa)
	T265_05845	Citrate synthase; Belongs to the citrate synthase family. (567 aa)
	T265_08115	Polyketide_cyc domain-containing protein. (234 aa)
	T265_05466	Malate dehydrogenase. (233 aa)
	T265_05297	Uncharacterized protein. (766 aa)
	T265_05844	Uncharacterized protein. (198 aa)
	T265_05892	Iso_dh domain-containing protein. (584 aa)
	T265_05900	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (529 aa)
	T265_07551	Reverse transcriptase domain-containing protein. (1382 aa)
	T265_08284	PHB domain-containing protein. (243 aa)
	T265_10291	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (420 aa)
	T265_14256	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (729 aa)
	T265_07278	Complex1_30kDa domain-containing protein; Belongs to the complex I 30 kDa subunit family. (268 aa)
	T265_07698	Uncharacterized protein. (302 aa)
	T265_09055	Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (159 aa)
	T265_08654	Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer. (180 aa)
	T265_11785	Lipoyl-binding domain-containing protein. (615 aa)
	T265_11829	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (361 aa)
	T265_08967	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (589 aa)
	T265_10620	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (407 aa)
	T265_09911	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (153 aa)
	T265_09992	Succinate dehydrogenase, cytochrome b556 subunit. (197 aa)
	T265_15016	Uncharacterized protein. (307 aa)
	T265_11799	Uncharacterized protein. (153 aa)
	T265_15831	Molybdopterin domain-containing protein. (123 aa)
	T265_11588	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (457 aa)
	T265_12045	Uncharacterized protein. (214 aa)
	T265_12110	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (257 aa)

Your Current Organism:

Opisthorchis viverrini

NCBI taxonomy Id: 6198
Other names: O. viverrini, Southeast Asian liver fluke

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T265_00432	T265_00964	A0A075A326	A0A075A452	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	Uncharacterized protein.	0.443
T265_00432	T265_01077	A0A075A326	A0A075AJ94	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).	0.999
T265_00432	T265_01591	A0A075A326	A0A074ZY39	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	Uncharacterized protein.	0.565
T265_00432	T265_01732	A0A075A326	A0A075A8R4	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.684
T265_00432	T265_02546	A0A075A326	A0A074ZZ26	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.697
T265_00432	T265_03074	A0A075A326	A0A074ZTL4	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	Uncharacterized protein.	0.519
T265_00432	T265_03241	A0A075A326	A0A074ZWL8	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	Succinate-CoA ligase subunit beta.	0.999
T265_00432	T265_03698	A0A075A326	A0A074ZRS1	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	ETF domain-containing protein.	0.881
T265_00432	T265_04260	A0A075A326	A0A075A0K4	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	Malate dehydrogenase.	0.725
T265_00432	T265_04624	A0A075A326	A0A074ZZ40	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.724
T265_00432	T265_05466	A0A075A326	A0A074ZKD1	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	Malate dehydrogenase.	0.852
T265_00432	T265_05624	A0A075A326	A0A075AF25	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.898
T265_00432	T265_05723	A0A075A326	A0A075AEY3	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	Uncharacterized protein.	0.802
T265_00432	T265_05844	A0A075A326	A0A074ZJ46	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	Uncharacterized protein.	0.861
T265_00432	T265_05845	A0A075A326	A0A074ZMM5	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	Citrate synthase; Belongs to the citrate synthase family.	0.861
T265_00432	T265_05892	A0A075A326	A0A074ZJ18	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	Iso_dh domain-containing protein.	0.924
T265_00432	T265_05900	A0A075A326	A0A074ZIT3	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone.	0.589
T265_00432	T265_06605	A0A075A326	A0A075ADI1	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	Uncharacterized protein.	0.418
T265_00432	T265_06847	A0A075A326	A0A075ACZ8	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	Putative fumarate hydratase, class II.	0.887
T265_00432	T265_06956	A0A075A326	A0A074ZQI6	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	Uncharacterized protein.	0.519