(33 nodes) SH2 domain network (Opisthorchis viverrini)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T265_10496	Tyrosine-protein kinase. (1085 aa)
	T265_15081	Uncharacterized protein. (1204 aa)
	T265_09745	SH2 domain-containing protein. (1080 aa)
	T265_09079	Uncharacterized protein. (676 aa)
	T265_09086	Uncharacterized protein. (583 aa)
	T265_08090	Uncharacterized protein. (837 aa)
	T265_10594	Uncharacterized protein. (333 aa)
	NTH1	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (976 aa)
	T265_06784	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1571 aa)
	T265_06464	Uncharacterized protein. (860 aa)
	T265_14202	Uncharacterized protein. (2202 aa)
	T265_08822	SH2 domain-containing protein. (604 aa)
	T265_05870	Uncharacterized protein. (1045 aa)
	T265_05581	Uncharacterized protein. (1713 aa)
	T265_06294	Tyrosine-protein kinase. (660 aa)
	T265_06196	Uncharacterized protein. (1567 aa)
	T265_06495	Tyrosine-protein kinase. (799 aa)
	T265_04412	Tyrosine-protein kinase. (556 aa)
	T265_13452	Uncharacterized protein. (434 aa)
	T265_13947	Tyrosine-protein kinase. (1014 aa)
	T265_05987	SH2 domain-containing protein. (1952 aa)
	T265_03544	SH2 domain-containing protein. (632 aa)
	T265_13141	SH2 domain-containing protein. (585 aa)
	T265_12862	Uncharacterized protein. (1083 aa)
	T265_02757	SH2 domain-containing protein. (902 aa)
	T265_01864	Tyrosine-protein kinase. (896 aa)
	T265_01776	Tyrosine-protein kinase. (1163 aa)
	T265_08093	Tyrosine-protein kinase. (1239 aa)
	T265_07913	Non-specific protein-tyrosine kinase. (839 aa)
	T265_07409	SH2 domain-containing protein. (1320 aa)
	T265_00100	SH2 domain-containing protein. (859 aa)
	T265_04637	Tyrosine-protein kinase. (685 aa)
	T265_03389	SH2 domain-containing protein. (1325 aa)

Your Current Organism:

Opisthorchis viverrini

NCBI taxonomy Id: 6198
Other names: O. viverrini, Southeast Asian liver fluke

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T265_00100	T265_01776	A0A075ADJ3	A0A075A1R7	SH2 domain-containing protein.	Tyrosine-protein kinase.	0.502
T265_00100	T265_01864	A0A075ADJ3	A0A075A0Z1	SH2 domain-containing protein.	Tyrosine-protein kinase.	0.502
T265_00100	T265_04412	A0A075ADJ3	A0A074ZSJ9	SH2 domain-containing protein.	Tyrosine-protein kinase.	0.502
T265_00100	T265_04637	A0A075ADJ3	A0A075AGB8	SH2 domain-containing protein.	Tyrosine-protein kinase.	0.502
T265_00100	T265_06294	A0A075ADJ3	A0A074ZKX5	SH2 domain-containing protein.	Tyrosine-protein kinase.	0.502
T265_00100	T265_06495	A0A075ADJ3	A0A074ZS89	SH2 domain-containing protein.	Tyrosine-protein kinase.	0.502
T265_00100	T265_07913	A0A075ADJ3	A0A075AA18	SH2 domain-containing protein.	Non-specific protein-tyrosine kinase.	0.502
T265_00100	T265_12862	A0A075ADJ3	A0A074ZXK8	SH2 domain-containing protein.	Uncharacterized protein.	0.502
T265_00100	T265_13452	A0A075ADJ3	A0A074ZTG2	SH2 domain-containing protein.	Uncharacterized protein.	0.608
T265_01776	T265_00100	A0A075A1R7	A0A075ADJ3	Tyrosine-protein kinase.	SH2 domain-containing protein.	0.502
T265_01776	T265_02757	A0A075A1R7	A0A074ZY81	Tyrosine-protein kinase.	SH2 domain-containing protein.	0.436
T265_01776	T265_06196	A0A075A1R7	A0A074ZL87	Tyrosine-protein kinase.	Uncharacterized protein.	0.411
T265_01776	T265_06464	A0A075A1R7	A0A074ZGD6	Tyrosine-protein kinase.	Uncharacterized protein.	0.484
T265_01776	T265_07409	A0A075A1R7	A0A075ABP4	Tyrosine-protein kinase.	SH2 domain-containing protein.	0.436
T265_01776	T265_09079	A0A075A1R7	A0A074Z6T7	Tyrosine-protein kinase.	Uncharacterized protein.	0.424
T265_01776	T265_09086	A0A075A1R7	A0A074Z740	Tyrosine-protein kinase.	Uncharacterized protein.	0.424
T265_01776	T265_10496	A0A075A1R7	A0A074Z283	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.422
T265_01776	T265_10594	A0A075A1R7	A0A074ZCR3	Tyrosine-protein kinase.	Uncharacterized protein.	0.512
T265_01776	T265_13452	A0A075A1R7	A0A074ZTG2	Tyrosine-protein kinase.	Uncharacterized protein.	0.523
T265_01776	T265_14202	A0A075A1R7	A0A074ZI73	Tyrosine-protein kinase.	Uncharacterized protein.	0.436