(62 nodes) Nucleic acid-binding, OB-fold network (Opisthorchis viverrini)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T265_08128	Ribosomal_L2_C domain-containing protein. (376 aa)
	T265_05960	Uncharacterized protein. (436 aa)
	T265_13902	AA_TRNA_LIGASE_II domain-containing protein. (571 aa)
	T265_00891	KH_dom_type_1 domain-containing protein. (323 aa)
	T265_07673	Uncharacterized protein. (1815 aa)
	T265_13817	Uncharacterized protein. (763 aa)
	T265_10611	AAA domain-containing protein; Belongs to the AAA ATPase family. (442 aa)
	T265_01106	RNB domain-containing protein; Belongs to the RNR ribonuclease family. (923 aa)
	T265_00433	Uncharacterized protein. (232 aa)
	T265_10217	AAA domain-containing protein; Belongs to the AAA ATPase family. (292 aa)
	T265_01569	DNA ligase. (724 aa)
	T265_01582	Uncharacterized protein. (533 aa)
	T265_09909	eIF-5a domain-containing protein. (192 aa)
	T265_00045	DNA helicase; Belongs to the MCM family. (807 aa)
	T265_00854	Uncharacterized protein. (975 aa)
	T265_00453	Uncharacterized protein. (1934 aa)
	T265_12992	S1 motif domain-containing protein. (1004 aa)
	T265_02267	Ribosomal_L2_C domain-containing protein. (459 aa)
	T265_08813	AAA domain-containing protein; Belongs to the AAA ATPase family. (417 aa)
	T265_08046	Ribosomal protein S23; Belongs to the universal ribosomal protein uS12 family. (145 aa)
	T265_07425	Ribosomal protein S17P; Belongs to the universal ribosomal protein uS17 family. (146 aa)
	T265_14289	Mcm10 domain-containing protein. (917 aa)
	T265_14169	Uncharacterized protein. (274 aa)
	T265_06700	CSP domain-containing protein. (213 aa)
	T265_13135	MCM domain-containing protein; Belongs to the MCM family. (1024 aa)
	T265_02634	KH_dom_type_1 domain-containing protein. (389 aa)
	T265_15308	Uncharacterized protein. (695 aa)
	T265_04757	CSD_1 domain-containing protein. (224 aa)
	T265_01989	DNA helicase; Belongs to the RuvB family. (887 aa)
	T265_05035	Uncharacterized protein. (157 aa)
	T265_01982	AAA domain-containing protein; Belongs to the AAA ATPase family. (386 aa)
	T265_02298	CSD_1 domain-containing protein. (471 aa)
	T265_13250	Uncharacterized protein; Belongs to the universal ribosomal protein uS12 family. (163 aa)
	T265_13006	MCM domain-containing protein; Belongs to the MCM family. (691 aa)
	T265_03124	S1 motif domain-containing protein. (329 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (767 aa)
	T265_06248	CSD_1 domain-containing protein. (480 aa)
	T265_13205	AAA domain-containing protein; Belongs to the AAA ATPase family. (426 aa)
	T265_14039	tRNA-binding domain-containing protein. (306 aa)
	T265_03600	DNA ligase. (865 aa)
	T265_14189	EXOSC1 domain-containing protein. (414 aa)
	T265_13381	DNA helicase; Belongs to the MCM family. (889 aa)
	T265_04330	Uncharacterized protein. (182 aa)
	T265_15623	Telo_bind domain-containing protein. (725 aa)
	T265_11299	Tyrosine--tRNA ligase. (1159 aa)
	T265_15873	Telo_bind domain-containing protein. (110 aa)
	T265_11298	Uncharacterized protein. (75 aa)
	T265_09312	Uncharacterized protein. (1002 aa)
	T265_08946	Lysine--tRNA ligase. (644 aa)
	T265_08785	DNA helicase; Belongs to the MCM family. (810 aa)
	T265_14648	RNA polymerase Rpb8. (156 aa)
	T265_08645	AAA domain-containing protein; Belongs to the AAA ATPase family. (623 aa)
	T265_09518	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (650 aa)
	T265_14751	RPA_C domain-containing protein. (261 aa)
	T265_07572	DNA helicase; Belongs to the MCM family. (885 aa)
	T265_08857	DNA ligase. (1154 aa)
	T265_14212	Uncharacterized protein. (1618 aa)
	T265_14198	CSD_1 domain-containing protein. (216 aa)
	T265_06784	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1571 aa)
	T265_14849	AA_TRNA_LIGASE_II domain-containing protein. (949 aa)
	T265_05275	AA_TRNA_LIGASE_II domain-containing protein. (550 aa)
	T265_13744	AA_TRNA_LIGASE_II domain-containing protein. (573 aa)

Your Current Organism:

Opisthorchis viverrini

NCBI taxonomy Id: 6198
Other names: O. viverrini, Southeast Asian liver fluke

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCM7	T265_00045	A0A074ZT85	A0A075A3E8	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	T265_01569	A0A074ZT85	A0A075A267	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA ligase.	0.849
MCM7	T265_01582	A0A074ZT85	A0A075A280	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Uncharacterized protein.	0.680
MCM7	T265_03600	A0A074ZT85	A0A074ZRS7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA ligase.	0.513
MCM7	T265_07572	A0A074ZT85	A0A074ZC04	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	T265_08785	A0A074ZT85	A0A074Z7X2	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	T265_08857	A0A074ZT85	A0A074ZCA3	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA ligase.	0.513
MCM7	T265_09518	A0A074ZT85	A0A074Z9X4	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.753
MCM7	T265_13006	A0A074ZT85	A0A074ZVV6	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	MCM domain-containing protein; Belongs to the MCM family.	0.999
MCM7	T265_13135	A0A074ZT85	A0A075AHY9	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	MCM domain-containing protein; Belongs to the MCM family.	0.928
MCM7	T265_13381	A0A074ZT85	A0A074ZPI3	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	T265_14289	A0A074ZT85	A0A075ABK5	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Mcm10 domain-containing protein.	0.996
MCM7	T265_14751	A0A074ZT85	A0A074ZBI0	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	RPA_C domain-containing protein.	0.817
T265_00045	MCM7	A0A075A3E8	A0A074ZT85	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
T265_00045	T265_01569	A0A075A3E8	A0A075A267	DNA helicase; Belongs to the MCM family.	DNA ligase.	0.776
T265_00045	T265_01582	A0A075A3E8	A0A075A280	DNA helicase; Belongs to the MCM family.	Uncharacterized protein.	0.733
T265_00045	T265_07572	A0A075A3E8	A0A074ZC04	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
T265_00045	T265_08785	A0A075A3E8	A0A074Z7X2	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
T265_00045	T265_09518	A0A075A3E8	A0A074Z9X4	DNA helicase; Belongs to the MCM family.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.861
T265_00045	T265_13006	A0A075A3E8	A0A074ZVV6	DNA helicase; Belongs to the MCM family.	MCM domain-containing protein; Belongs to the MCM family.	0.999