(49 nodes) Pyruvate metabolism and Citric Acid (TCA) cycle network (Opisthorchis viverrini)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	T265_04810	Uncharacterized protein. (1109 aa)
	T265_05845	Citrate synthase; Belongs to the citrate synthase family. (567 aa)
	T265_04307	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (467 aa)
	T265_13783	Succinate-CoA ligase subunit beta. (560 aa)
	T265_06902	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (225 aa)
	T265_04552	PPM-type phosphatase domain-containing protein; Belongs to the PP2C family. (675 aa)
	T265_16243	Malate dehydrogenase. (113 aa)
	T265_12303	Lactamase_B domain-containing protein. (134 aa)
	T265_15976	Protein-serine/threonine kinase. (168 aa)
	T265_03119	Uncharacterized protein. (594 aa)
	T265_03891	PPM-type phosphatase domain-containing protein. (580 aa)
	T265_15668	Uncharacterized protein. (674 aa)
	T265_03241	Succinate-CoA ligase subunit beta. (373 aa)
	T265_01591	Uncharacterized protein. (432 aa)
	T265_02546	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (397 aa)
	T265_04624	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (586 aa)
	T265_01709	Lactamase_B domain-containing protein. (370 aa)
	T265_00432	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (326 aa)
	T265_00275	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (498 aa)
	T265_00108	Protein-serine/threonine kinase. (476 aa)
	T265_02970	Protein-serine/threonine kinase. (740 aa)
	T265_09243	Ldh_1_N domain-containing protein. (295 aa)
	T265_09045	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (328 aa)
	T265_07717	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (369 aa)
	T265_06847	Putative fumarate hydratase, class II. (494 aa)
	T265_00030	Reverse transcriptase domain-containing protein. (565 aa)
	T265_02080	Peripheral subunit-binding (PSBD) domain-containing protein. (427 aa)
	T265_15709	Ig-like domain-containing protein. (359 aa)
	T265_11532	Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. (485 aa)
	T265_11588	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (457 aa)
	T265_09992	Succinate dehydrogenase, cytochrome b556 subunit. (197 aa)
	T265_09911	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (153 aa)
	T265_10884	DAO domain-containing protein. (455 aa)
	T265_10862	Uncharacterized protein; Belongs to the GST superfamily. (213 aa)
	T265_09297	Dihydrolipoyl dehydrogenase. (498 aa)
	T265_12101	Lactamase_B domain-containing protein. (268 aa)
	T265_07551	Reverse transcriptase domain-containing protein. (1382 aa)
	T265_10291	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (420 aa)
	T265_14256	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (729 aa)
	T265_09319	FAA_hydrolase domain-containing protein. (95 aa)
	T265_09613	Malic enzyme. (586 aa)
	T265_11785	Lipoyl-binding domain-containing protein. (615 aa)
	T265_11829	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (361 aa)
	T265_09047	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (328 aa)
	T265_01077	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (278 aa)
	T265_09244	Ldh_1_C domain-containing protein. (172 aa)
	T265_09046	Uncharacterized protein; Belongs to the LDH/MDH superfamily. (282 aa)
	T265_05844	Uncharacterized protein. (198 aa)
	T265_05466	Malate dehydrogenase. (233 aa)

Your Current Organism:

Opisthorchis viverrini

NCBI taxonomy Id: 6198
Other names: O. viverrini, Southeast Asian liver fluke

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T265_00030	T265_00432	A0A075ADF5	A0A075A326	Reverse transcriptase domain-containing protein.	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	0.514
T265_00030	T265_01077	A0A075ADF5	A0A075AJ94	Reverse transcriptase domain-containing protein.	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).	0.618
T265_00030	T265_05844	A0A075ADF5	A0A074ZJ46	Reverse transcriptase domain-containing protein.	Uncharacterized protein.	0.789
T265_00030	T265_05845	A0A075ADF5	A0A074ZMM5	Reverse transcriptase domain-containing protein.	Citrate synthase; Belongs to the citrate synthase family.	0.789
T265_00030	T265_06847	A0A075ADF5	A0A075ACZ8	Reverse transcriptase domain-containing protein.	Putative fumarate hydratase, class II.	0.861
T265_00030	T265_07551	A0A075ADF5	A0A074ZGT1	Reverse transcriptase domain-containing protein.	Reverse transcriptase domain-containing protein.	0.477
T265_00030	T265_09297	A0A075ADF5	A0A074Z6C1	Reverse transcriptase domain-containing protein.	Dihydrolipoyl dehydrogenase.	0.413
T265_00030	T265_10884	A0A075ADF5	A0A074Z4Z1	Reverse transcriptase domain-containing protein.	DAO domain-containing protein.	0.902
T265_00030	T265_14256	A0A075ADF5	A0A074ZDF6	Reverse transcriptase domain-containing protein.	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	0.507
T265_00030	T265_15668	A0A075ADF5	A0A074ZV60	Reverse transcriptase domain-containing protein.	Uncharacterized protein.	0.683
T265_00108	T265_00275	A0A075A3L6	A0A075A327	Protein-serine/threonine kinase.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.712
T265_00108	T265_01591	A0A075A3L6	A0A074ZY39	Protein-serine/threonine kinase.	Uncharacterized protein.	0.609
T265_00108	T265_02080	A0A075A3L6	A0A075AII8	Protein-serine/threonine kinase.	Peripheral subunit-binding (PSBD) domain-containing protein.	0.712
T265_00108	T265_07717	A0A075A3L6	A0A075AAV0	Protein-serine/threonine kinase.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.609
T265_00108	T265_09297	A0A075A3L6	A0A074Z6C1	Protein-serine/threonine kinase.	Dihydrolipoyl dehydrogenase.	0.654
T265_00108	T265_11785	A0A075A3L6	A0A074Z881	Protein-serine/threonine kinase.	Lipoyl-binding domain-containing protein.	0.569
T265_00108	T265_11829	A0A075A3L6	A0A074Z811	Protein-serine/threonine kinase.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.655
T265_00275	T265_00108	A0A075A327	A0A075A3L6	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Protein-serine/threonine kinase.	0.712
T265_00275	T265_00432	A0A075A327	A0A075A326	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	0.903
T265_00275	T265_01077	A0A075A327	A0A075AJ94	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).	0.761