(37 nodes) RNA Polymerase I Transcription network (Opisthorchis viverrini)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T265_02684	Uncharacterized protein; Belongs to the RNA polymerase beta chain family. (1002 aa)
	T265_12159	RNA_pol_Rpb1_5 domain-containing protein. (134 aa)
	T265_03747	Uncharacterized protein. (770 aa)
	T265_15386	MAT1 domain-containing protein. (1203 aa)
	T265_00617	SprT-like domain-containing protein. (1080 aa)
	T265_00138	Helicase ATP-binding domain-containing protein. (846 aa)
	T265_05828	Core histone H2A/H2B/H3/H4; Belongs to the histone H2B family. (108 aa)
	T265_05709	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (172 aa)
	T265_05686	Uncharacterized protein. (214 aa)
	T265_02021	Uncharacterized protein. (1166 aa)
	T265_00261	Uncharacterized protein. (931 aa)
	T265_12402	Histone H2B; Belongs to the histone H2B family. (64 aa)
	T265_12333	Uncharacterized protein. (44 aa)
	T265_12280	Uncharacterized protein. (98 aa)
	T265_03554	Histone H2B; Belongs to the histone H2B family. (122 aa)
	T265_11911	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1785 aa)
	T265_15522	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (94 aa)
	T265_11517	MBD domain-containing protein. (355 aa)
	T265_11049	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (95 aa)
	T265_14648	RNA polymerase Rpb8. (156 aa)
	T265_09750	Histone H2A; Belongs to the histone H2A family. (225 aa)
	T265_09412	Uncharacterized protein. (67 aa)
	T265_09123	Uncharacterized protein. (923 aa)
	T265_07453	Uncharacterized protein. (253 aa)
	T265_10182	RPOLD domain-containing protein. (483 aa)
	T265_06756	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (547 aa)
	T265_06719	GATA-type domain-containing protein. (437 aa)
	T265_06604	Uncharacterized protein. (2022 aa)
	T265_06498	Uncharacterized protein. (825 aa)
	T265_05767	WD_REPEATS_REGION domain-containing protein. (473 aa)
	T265_07919	Uncharacterized protein. (584 aa)
	T265_14381	Uncharacterized protein. (1442 aa)
	T265_05840	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	T265_13707	Transcription factor TFIID. (265 aa)
	T265_03178	Uncharacterized protein. (416 aa)
	T265_06245	RNA polymerase K / subunit. (136 aa)
	T265_13439	Uncharacterized protein. (883 aa)

Your Current Organism:

Opisthorchis viverrini

NCBI taxonomy Id: 6198
Other names: O. viverrini, Southeast Asian liver fluke

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T265_00138	T265_00261	A0A075A7E3	A0A075AJW4	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.999
T265_00138	T265_00617	A0A075A7E3	A0A075A2A6	Helicase ATP-binding domain-containing protein.	SprT-like domain-containing protein.	0.439
T265_00138	T265_02684	A0A075A7E3	A0A074ZU55	Helicase ATP-binding domain-containing protein.	Uncharacterized protein; Belongs to the RNA polymerase beta chain family.	0.813
T265_00138	T265_05686	A0A075A7E3	A0A075AEZ5	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.828
T265_00138	T265_05709	A0A075A7E3	A0A075AEX9	Helicase ATP-binding domain-containing protein.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.504
T265_00138	T265_05840	A0A075A7E3	A0A074ZML9	Helicase ATP-binding domain-containing protein.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.504
T265_00138	T265_06245	A0A075A7E3	A0A074ZT17	Helicase ATP-binding domain-containing protein.	RNA polymerase K / subunit.	0.961
T265_00138	T265_06498	A0A075A7E3	A0A074ZG93	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.999
T265_00138	T265_06756	A0A075A7E3	A0A074ZFD8	Helicase ATP-binding domain-containing protein.	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.	0.999
T265_00138	T265_07453	A0A075A7E3	A0A074ZCI3	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.969
T265_00138	T265_09412	A0A075A7E3	A0A074ZA99	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.961
T265_00138	T265_09750	A0A075A7E3	A0A074Z8Z4	Helicase ATP-binding domain-containing protein.	Histone H2A; Belongs to the histone H2A family.	0.448
T265_00138	T265_10182	A0A075A7E3	A0A074ZE82	Helicase ATP-binding domain-containing protein.	RPOLD domain-containing protein.	0.850
T265_00138	T265_11049	A0A075A7E3	A0A074Z4F0	Helicase ATP-binding domain-containing protein.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.504
T265_00138	T265_11911	A0A075A7E3	A0A074YWU0	Helicase ATP-binding domain-containing protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.568
T265_00138	T265_12159	A0A075A7E3	A0A074ZUA2	Helicase ATP-binding domain-containing protein.	RNA_pol_Rpb1_5 domain-containing protein.	0.568
T265_00138	T265_12333	A0A075A7E3	A0A074YTW3	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.568
T265_00138	T265_13439	A0A075A7E3	A0A074ZTQ0	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.828
T265_00138	T265_13707	A0A075A7E3	A0A074ZQ03	Helicase ATP-binding domain-containing protein.	Transcription factor TFIID.	0.962
T265_00138	T265_14381	A0A075A7E3	A0A074ZMJ9	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.900