(79 nodes) Peptidase activity, and Endopeptidase regulator activity network (Echinococcus granulosus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EGR_01303	Estrogen regulated protein EP45; Belongs to the serpin family. (451 aa)
	EGR_02699	Cathepsin l cysteine peptidase; Belongs to the peptidase C1 family. (335 aa)
	EGR_09190	Mitochondrial substrate solute carrier; Belongs to the mitochondrial carrier (TC 2.A.29) family. (291 aa)
	EGR_01472	Acylamino-acid-releasing enzyme. (824 aa)
	EGR_11299	Carboxypeptidase A2. (378 aa)
	EGR_11281	Carboxypeptidase A1. (369 aa)
	EGR_10955	Putative aminopeptidase. (153 aa)
	EGR_10706	Puromycin-sensitive aminopeptidase. (704 aa)
	EGR_10709	Puromycin-sensitive aminopeptidase. (277 aa)
	EGR_10570	Putative Xaa-Pro aminopeptidase 3. (491 aa)
	EGR_10236	Gamma-secretase subunit APH-1A. (278 aa)
	EGR_10121	Carboxypeptidase; Belongs to the peptidase S10 family. (516 aa)
	EGR_10096	Amyloid beta A4 protein. (98 aa)
	EGR_09462	Putative aminopeptidase W07G4.4. (100 aa)
	EGR_08815	Matrix metalloproteinase-25. (569 aa)
	EGR_08923	Tripeptidyl-peptidase 2. (1751 aa)
	EGR_08881	Plasminogen. (2149 aa)
	EGR_07638	Cathepsin L; Belongs to the peptidase C1 family. (122 aa)
	EGR_07480	Dipeptidyl aminopeptidase-like protein 6; Belongs to the peptidase S9B family. (987 aa)
	EGR_10235	Carboxypeptidase A2. (431 aa)
	EGR_07418	E3 ubiquitin-protein ligase. (318 aa)
	EGR_07423	RING finger protein. (353 aa)
	EGR_07237	YccV-like domain-containing protein. (288 aa)
	EGR_07548	Uncharacterized protein. (391 aa)
	EGR_06555	Presequence protease. (1010 aa)
	EGR_06384	Membrane-bound transcription factor site-1 protease. (276 aa)
	EGR_07173	Lysosomal aspartic protease; Belongs to the peptidase A1 family. (425 aa)
	EGR_06292	PC3-like endoprotease variant B. (540 aa)
	EGR_09137	RING finger protein. (244 aa)
	EGR_06595	Putative aminopeptidase W07G4.4. (98 aa)
	EGR_05078	Disintegrin and metalloproteinase domain-containing protein. (244 aa)
	EGR_04722	Subfamily M3A non-peptidaseue (M03 family). (823 aa)
	EGR_05317	Papilin. (1540 aa)
	EGR_08123	Cathepsin L; Belongs to the peptidase C1 family. (134 aa)
	EGR_04811	Serpin B9; Belongs to the serpin family. (336 aa)
	EGR_04531	Proactivator polypeptide. (935 aa)
	EGR_04427	Prolyl endopeptidase. (688 aa)
	EGR_07187	Ubiquitin hydrolase; Belongs to the peptidase C19 family. (837 aa)
	EGR_04322	Aspartyl aminopeptidase. (1181 aa)
	EGR_03291	Nardilysin. (343 aa)
	EGR_03437	Endothelin-converting enzyme. (800 aa)
	EGR_03462	Rhomboid family member. (942 aa)
	EGR_03297	Xaa-Pro dipeptidase. (545 aa)
	EGR_02882	Peptidylprolyl isomerase. (356 aa)
	EGR_06483	Transmembrane protease serine 2; Belongs to the peptidase S1 family. (775 aa)
	EGR_06383	Membrane-bound transcription factor site-1 protease. (199 aa)
	EGR_03294	Nardilysin. (436 aa)
	EGR_03024	Uncharacterized protein. (770 aa)
	EGR_10496	Putative aminopeptidase. (95 aa)
	EGR_02555	Leukotriene A-4 hydrolase. (639 aa)
	EGR_01997	Murinoglobulin-2. (1454 aa)
	EGR_01660	Xaa-Pro aminopeptidase. (1025 aa)
	EGR_02195	Cathepsin L-like proteinase; Belongs to the peptidase C1 family. (357 aa)
	EGR_01965	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8. (840 aa)
	EGR_04065	Tetraspanin. (324 aa)
	EGR_01583	Zinc finger SWIM domain-containing protein 2. (310 aa)
	EGR_08495	Uncharacterized protein. (345 aa)
	EGR_00543	Furin-like protease 1, isoforms 1/1-X/2; Belongs to the peptidase S8 family. (926 aa)
	EGR_03293	Nardilysin. (473 aa)
	EGR_01229	Mitochondrial intermediate peptidase. (1184 aa)
	EGR_03160	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1123 aa)
	EGR_00222	Cathepsin B; Belongs to the peptidase C1 family. (672 aa)
	EGR_00581	ADAM 17-like protease. (944 aa)
	EGR_00215	E3 ubiquitin-protein ligase. (226 aa)
	EGR_06385	Membrane-bound transcription factor site-1 protease. (429 aa)
	EGR_06293	P/Homo B domain-containing protein. (153 aa)
	EGR_00916	Proprotein convertase subtilisin/kexin type; Belongs to the peptidase S8 family. (1413 aa)
	EGR_05548	Insulin-degrading enzyme; Belongs to the peptidase M16 family. (1022 aa)
	EGR_05280	Uncharacterized protein. (249 aa)
	EGR_05300	Gamma-secretase subunit pen-2. (101 aa)
	EGR_05315	Uncharacterized protein. (166 aa)
	EGR_05077	Disintegrin and metalloproteinase domain-containing protein. (193 aa)
	EGR_03025	Uncharacterized protein. (2124 aa)
	EGR_03125	Serine protease inhibitor; Belongs to the serpin family. (367 aa)
	EGR_02545	Exosome complex exonuclease RRP40. (328 aa)
	EGR_01302	Serine protease inhibitor; Belongs to the serpin family. (393 aa)
	EGR_01087	Cathepsin L; Belongs to the peptidase C1 family. (368 aa)
	EGR_00303	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (387 aa)
	EGR_00378	Uncharacterized protein. (629 aa)

Your Current Organism:

Echinococcus granulosus

NCBI taxonomy Id: 6210
Other names: E. granulosus, Echinococcus granulosus G1 strain, Echinococcus granulosus G2 strain, Echinococcus granulosus G3 strain, Echinococcus granulosus Tasmanian sheep strain, Echinococcus granulosus buffalo strain, Echinococcus granulosus s. s., Echinococcus granulosus sensu stricto, Echinococcus granulosus sheep strain

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGR_00215	EGR_00543	W6UWF6	W6UTH3	E3 ubiquitin-protein ligase.	Furin-like protease 1, isoforms 1/1-X/2; Belongs to the peptidase S8 family.	0.549
EGR_00215	EGR_00916	W6UWF6	W6V0G5	E3 ubiquitin-protein ligase.	Proprotein convertase subtilisin/kexin type; Belongs to the peptidase S8 family.	0.549
EGR_00215	EGR_06292	W6UWF6	W6UBU9	E3 ubiquitin-protein ligase.	PC3-like endoprotease variant B.	0.549
EGR_00215	EGR_06293	W6UWF6	W6UZ44	E3 ubiquitin-protein ligase.	P/Homo B domain-containing protein.	0.549
EGR_00215	EGR_06383	W6UWF6	W6UKU4	E3 ubiquitin-protein ligase.	Membrane-bound transcription factor site-1 protease.	0.505
EGR_00215	EGR_06384	W6UWF6	W6UBG4	E3 ubiquitin-protein ligase.	Membrane-bound transcription factor site-1 protease.	0.505
EGR_00215	EGR_06385	W6UWF6	W6UYQ5	E3 ubiquitin-protein ligase.	Membrane-bound transcription factor site-1 protease.	0.505
EGR_00215	EGR_08923	W6UWF6	W6U771	E3 ubiquitin-protein ligase.	Tripeptidyl-peptidase 2.	0.505
EGR_00222	EGR_00543	W6UUL0	W6UTH3	Cathepsin B; Belongs to the peptidase C1 family.	Furin-like protease 1, isoforms 1/1-X/2; Belongs to the peptidase S8 family.	0.489
EGR_00222	EGR_00916	W6UUL0	W6V0G5	Cathepsin B; Belongs to the peptidase C1 family.	Proprotein convertase subtilisin/kexin type; Belongs to the peptidase S8 family.	0.489
EGR_00222	EGR_01087	W6UUL0	W6VB28	Cathepsin B; Belongs to the peptidase C1 family.	Cathepsin L; Belongs to the peptidase C1 family.	0.665
EGR_00222	EGR_01302	W6UUL0	W6VA91	Cathepsin B; Belongs to the peptidase C1 family.	Serine protease inhibitor; Belongs to the serpin family.	0.436
EGR_00222	EGR_01303	W6UUL0	U6IXU7	Cathepsin B; Belongs to the peptidase C1 family.	Estrogen regulated protein EP45; Belongs to the serpin family.	0.436
EGR_00222	EGR_02195	W6UUL0	W6UQY1	Cathepsin B; Belongs to the peptidase C1 family.	Cathepsin L-like proteinase; Belongs to the peptidase C1 family.	0.628
EGR_00222	EGR_02545	W6UUL0	W6V8B0	Cathepsin B; Belongs to the peptidase C1 family.	Exosome complex exonuclease RRP40.	0.590
EGR_00222	EGR_02699	W6UUL0	U6IZB4	Cathepsin B; Belongs to the peptidase C1 family.	Cathepsin l cysteine peptidase; Belongs to the peptidase C1 family.	0.679
EGR_00222	EGR_03125	W6UUL0	W6V6R7	Cathepsin B; Belongs to the peptidase C1 family.	Serine protease inhibitor; Belongs to the serpin family.	0.436
EGR_00222	EGR_04531	W6UUL0	W6UI25	Cathepsin B; Belongs to the peptidase C1 family.	Proactivator polypeptide.	0.669
EGR_00222	EGR_04811	W6UUL0	W6UGX5	Cathepsin B; Belongs to the peptidase C1 family.	Serpin B9; Belongs to the serpin family.	0.436
EGR_00222	EGR_07173	W6UUL0	W6UBQ8	Cathepsin B; Belongs to the peptidase C1 family.	Lysosomal aspartic protease; Belongs to the peptidase A1 family.	0.921

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