(15 nodes) Site of double-strand break network (Echinococcus granulosus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	EGR_05525	DNA damage-binding protein. (1332 aa)
	EGR_02052	Checkpoint protein HUS1. (1022 aa)
	EGR_03058	Telomerase Cajal body protein. (279 aa)
	EGR_01785	E3 ubiquitin-protein ligase. (224 aa)
	EGR_04047	Pre-mRNA-processing factor. (571 aa)
	EGR_04857	Uncharacterized protein. (238 aa)
	EGR_02795	Tumor suppressor p53-binding protein. (1108 aa)
	EGR_07517	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (342 aa)
	EGR_07425	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (680 aa)
	EGR_09644	DNA polymerase eta. (578 aa)
	EGR_08353	NAD-dependent deacetylase sirtuin-7. (209 aa)
	EGR_06722	SAM domain and HD domain-containing protein. (561 aa)
	EGR_06332	WD repeat-containing protein 70. (617 aa)
	EGR_08924	Uncharacterized protein. (453 aa)
	EGR_04351	annotation not available (1870 aa)

Your Current Organism:

Echinococcus granulosus

NCBI taxonomy Id: 6210
Other names: E. granulosus, Echinococcus granulosus G1 strain, Echinococcus granulosus G2 strain, Echinococcus granulosus G3 strain, Echinococcus granulosus Tasmanian sheep strain, Echinococcus granulosus buffalo strain, Echinococcus granulosus s. s., Echinococcus granulosus sensu stricto, Echinococcus granulosus sheep strain

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGR_01785	EGR_02795	W6V9I6	W6UVB2	E3 ubiquitin-protein ligase.	Tumor suppressor p53-binding protein.	0.851
EGR_01785	EGR_07425	W6V9I6	U6JIY4	E3 ubiquitin-protein ligase.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.684
EGR_02052	EGR_02795	W6UP12	W6UVB2	Checkpoint protein HUS1.	Tumor suppressor p53-binding protein.	0.843
EGR_02052	EGR_07425	W6UP12	U6JIY4	Checkpoint protein HUS1.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.818
EGR_02052	EGR_07517	W6UP12	U6IU35	Checkpoint protein HUS1.	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily.	0.698
EGR_02795	EGR_01785	W6UVB2	W6V9I6	Tumor suppressor p53-binding protein.	E3 ubiquitin-protein ligase.	0.851
EGR_02795	EGR_02052	W6UVB2	W6UP12	Tumor suppressor p53-binding protein.	Checkpoint protein HUS1.	0.843
EGR_02795	EGR_04351	W6UVB2	W6UGS5	Tumor suppressor p53-binding protein.	annotation not available	0.544
EGR_02795	EGR_07425	W6UVB2	U6JIY4	Tumor suppressor p53-binding protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.860
EGR_02795	EGR_07517	W6UVB2	U6IU35	Tumor suppressor p53-binding protein.	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily.	0.791
EGR_03058	EGR_09644	W6UUJ1	W6U340	Telomerase Cajal body protein.	DNA polymerase eta.	0.556
EGR_04047	EGR_06332	W6V4F6	W6UBL1	Pre-mRNA-processing factor.	WD repeat-containing protein 70.	0.799
EGR_04351	EGR_02795	W6UGS5	W6UVB2	annotation not available	Tumor suppressor p53-binding protein.	0.544
EGR_05525	EGR_06722	W6UFH1	W6UBH8	DNA damage-binding protein.	SAM domain and HD domain-containing protein.	0.570
EGR_05525	EGR_08353	W6UFH1	W6U6F6	DNA damage-binding protein.	NAD-dependent deacetylase sirtuin-7.	0.483
EGR_06332	EGR_04047	W6UBL1	W6V4F6	WD repeat-containing protein 70.	Pre-mRNA-processing factor.	0.799
EGR_06722	EGR_05525	W6UBH8	W6UFH1	SAM domain and HD domain-containing protein.	DNA damage-binding protein.	0.570
EGR_07425	EGR_01785	U6JIY4	W6V9I6	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	E3 ubiquitin-protein ligase.	0.684
EGR_07425	EGR_02052	U6JIY4	W6UP12	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Checkpoint protein HUS1.	0.818
EGR_07425	EGR_02795	U6JIY4	W6UVB2	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Tumor suppressor p53-binding protein.	0.860

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