(42 nodes) Mixed, incl. CDC42 GTPase cycle, and Small GTPase Rho network (Anopheles funestus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A182R1K6	Uncharacterized protein. (1823 aa)
	A0A182R4B1	Rho-GAP domain-containing protein. (690 aa)
	A0A182R656	Uncharacterized protein. (195 aa)
	A0A182R8V6	Rho-GAP domain-containing protein. (1087 aa)
	A0A182RAI9	Uncharacterized protein. (200 aa)
	A0A182RBE8	Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (524 aa)
	A0A182RC06	Uncharacterized protein. (192 aa)
	A0A182RGP4	Uncharacterized protein. (1121 aa)
	A0A182RHF1	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (126 aa)
	A0A182RI03	Rho-GAP domain-containing protein. (340 aa)
	A0A182RJF3	Uncharacterized protein. (700 aa)
	A0A182RJK1	Uncharacterized protein. (1884 aa)
	A0A182RKX5	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1412 aa)
	A0A182RLM4	Uncharacterized protein. (278 aa)
	A0A182RR36	BTB domain-containing protein. (723 aa)
	A0A182RTZ5	Uncharacterized protein. (497 aa)
	A0A182RUM2	Protein kinase domain-containing protein. (532 aa)
	A0A182RV76	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (186 aa)
	A0A182RXF5	Uncharacterized protein. (1417 aa)
	A0A182RYW6	Non-specific serine/threonine protein kinase. (869 aa)
	A0A182S528	Uncharacterized protein. (376 aa)
	A0A4Y0B7J2	Uncharacterized protein. (1411 aa)
	A0A4Y0BFY0	Uncharacterized protein. (1279 aa)
	A0A4Y0BGQ7	Uncharacterized protein. (69 aa)
	A0A4Y0BH18	Non-specific serine/threonine protein kinase. (686 aa)
	A0A4Y0BH21	Uncharacterized protein. (4052 aa)
	A0A4Y0BI89	Uncharacterized protein. (1194 aa)
	A0A4Y0BIB7	Uncharacterized protein. (658 aa)
	A0A4Y0BIF8	PH domain-containing protein. (1370 aa)
	A0A4Y0BJL5	Uncharacterized protein. (2330 aa)
	A0A4Y0BJV6	Uncharacterized protein. (1892 aa)
	A0A4Y0BLJ0	Uncharacterized protein. (1978 aa)
	A0A4Y0BLS3	Uncharacterized protein. (192 aa)
	A0A4Y0BM73	Uncharacterized protein. (911 aa)
	A0A4Y0BNK3	Uncharacterized protein. (1545 aa)
	A0A4Y0BPE8	Uncharacterized protein. (673 aa)
	A0A4Y0BPJ8	Uncharacterized protein. (1143 aa)
	A0A4Y0BPV3	Uncharacterized protein. (469 aa)
	A0A4Y0BRP3	GBD/FH3 domain-containing protein. (871 aa)
	A0A4Y0BRV6	Uncharacterized protein. (207 aa)
	A0A4Y0BWA1	GBD/FH3 domain-containing protein. (1046 aa)
	A0A4Y0BWC3	Uncharacterized protein. (215 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A182R1K6	A0A182R656	Uncharacterized protein.	Uncharacterized protein.	0.782
A0A182R1K6	A0A182R8V6	Uncharacterized protein.	Rho-GAP domain-containing protein.	0.517
A0A182R1K6	A0A182RBE8	Uncharacterized protein.	Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.690
A0A182R1K6	A0A182RC06	Uncharacterized protein.	Uncharacterized protein.	0.782
A0A182R1K6	A0A182RGP4	Uncharacterized protein.	Uncharacterized protein.	0.748
A0A182R1K6	A0A182RHF1	Uncharacterized protein.	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	0.953
A0A182R1K6	A0A182RI03	Uncharacterized protein.	Rho-GAP domain-containing protein.	0.421
A0A182R1K6	A0A182RJK1	Uncharacterized protein.	Uncharacterized protein.	0.954
A0A182R1K6	A0A182RKX5	Uncharacterized protein.	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.704
A0A182R1K6	A0A182RLM4	Uncharacterized protein.	Uncharacterized protein.	0.566
A0A182R1K6	A0A182RR36	Uncharacterized protein.	BTB domain-containing protein.	0.859
A0A182R1K6	A0A182RTZ5	Uncharacterized protein.	Uncharacterized protein.	0.554
A0A182R1K6	A0A182RV76	Uncharacterized protein.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.561
A0A182R1K6	A0A182S528	Uncharacterized protein.	Uncharacterized protein.	0.691
A0A182R1K6	A0A4Y0BGQ7	Uncharacterized protein.	Uncharacterized protein.	0.517
A0A182R1K6	A0A4Y0BH21	Uncharacterized protein.	Uncharacterized protein.	0.506
A0A182R1K6	A0A4Y0BI89	Uncharacterized protein.	Uncharacterized protein.	0.421
A0A182R1K6	A0A4Y0BIB7	Uncharacterized protein.	Uncharacterized protein.	0.636
A0A182R1K6	A0A4Y0BIF8	Uncharacterized protein.	PH domain-containing protein.	0.737
A0A182R1K6	A0A4Y0BLJ0	Uncharacterized protein.	Uncharacterized protein.	0.421