(34 nodes) RHO GTPases Activate WASPs and WAVEs, and Actin filament network formation network (Anopheles funestus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	A0A182R1I3	WH2 domain-containing protein. (705 aa)
	A0A182R3P8	Uncharacterized protein. (723 aa)
	A0A182R651	Uncharacterized protein. (1060 aa)
	A0A182R7H8	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1287 aa)
	A0A182R7S4	Adenylyl cyclase-associated protein; Belongs to the CAP family. (426 aa)
	A0A182R8E3	Uncharacterized protein. (343 aa)
	A0A182R8J6	Uncharacterized protein. (376 aa)
	A0A182RCA2	WH2 domain-containing protein. (642 aa)
	A0A182RCI7	SH3 domain-containing protein. (810 aa)
	A0A182RD42	Urb2 domain-containing protein. (1457 aa)
	A0A182REG2	Uncharacterized protein. (615 aa)
	A0A182RGL1	Uncharacterized protein. (427 aa)
	A0A182RIZ2	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (304 aa)
	A0A182RJ38	Uncharacterized protein. (555 aa)
	A0A182RKH8	Uncharacterized protein; Belongs to the actin family. (229 aa)
	A0A182RLY0	WH2 domain-containing protein. (92 aa)
	A0A182RM36	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (395 aa)
	A0A182RNJ7	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
	A0A182RPI9	SH3 domain-containing protein. (443 aa)
	A0A182RPX3	Uncharacterized protein. (370 aa)
	A0A182RSJ6	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (374 aa)
	A0A182RTL3	Uncharacterized protein. (376 aa)
	A0A182RTN0	Uncharacterized protein; Belongs to the actin family. (418 aa)
	A0A182RUN5	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (219 aa)
	A0A182RZM2	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
	A0A182S047	Uncharacterized protein. (464 aa)
	A0A182S4J5	Uncharacterized protein. (376 aa)
	A0A4Y0ALL7	Uncharacterized protein. (722 aa)
	A0A4Y0BD37	Uncharacterized protein. (75 aa)
	A0A4Y0BIK4	Uncharacterized protein. (631 aa)
	A0A4Y0BM76	Phorbol-ester/DAG-type domain-containing protein. (1057 aa)
	A0A4Y0BP58	Uncharacterized protein. (565 aa)
	A0A4Y0BTP8	Uncharacterized protein. (1121 aa)
	A0A4Y0BUK4	WD_REPEATS_REGION domain-containing protein. (603 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A182R1I3	A0A182R651	WH2 domain-containing protein.	Uncharacterized protein.	0.528
A0A182R1I3	A0A182R7H8	WH2 domain-containing protein.	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	0.559
A0A182R1I3	A0A182R8J6	WH2 domain-containing protein.	Uncharacterized protein.	0.621
A0A182R1I3	A0A182RCA2	WH2 domain-containing protein.	WH2 domain-containing protein.	0.612
A0A182R1I3	A0A182RCI7	WH2 domain-containing protein.	SH3 domain-containing protein.	0.722
A0A182R1I3	A0A182REG2	WH2 domain-containing protein.	Uncharacterized protein.	0.762
A0A182R1I3	A0A182RGL1	WH2 domain-containing protein.	Uncharacterized protein.	0.590
A0A182R1I3	A0A182RIZ2	WH2 domain-containing protein.	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.722
A0A182R1I3	A0A182RJ38	WH2 domain-containing protein.	Uncharacterized protein.	0.997
A0A182R1I3	A0A182RKH8	WH2 domain-containing protein.	Uncharacterized protein; Belongs to the actin family.	0.621
A0A182R1I3	A0A182RLY0	WH2 domain-containing protein.	WH2 domain-containing protein.	0.953
A0A182R1I3	A0A182RM36	WH2 domain-containing protein.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.863
A0A182R1I3	A0A182RNJ7	WH2 domain-containing protein.	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family.	0.730
A0A182R1I3	A0A182RPI9	WH2 domain-containing protein.	SH3 domain-containing protein.	0.627
A0A182R1I3	A0A182RPX3	WH2 domain-containing protein.	Uncharacterized protein.	0.644
A0A182R1I3	A0A182RSJ6	WH2 domain-containing protein.	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.713
A0A182R1I3	A0A182RTL3	WH2 domain-containing protein.	Uncharacterized protein.	0.621
A0A182R1I3	A0A182RTN0	WH2 domain-containing protein.	Uncharacterized protein; Belongs to the actin family.	0.852
A0A182R1I3	A0A182RUN5	WH2 domain-containing protein.	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.	0.766
A0A182R1I3	A0A182RZM2	WH2 domain-containing protein.	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.781