(45 nodes) Cross-presentation of soluble exogenous antigens (endosomes) network (Anopheles funestus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A182R1X9	MPN domain-containing protein. (338 aa)
	A0A182R3V0	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (900 aa)
	A0A182R489	MPN domain-containing protein. (1598 aa)
	A0A182R4A9	Proteasome subunit beta. (205 aa)
	A0A182R513	Uncharacterized protein. (486 aa)
	A0A182R676	PCI domain-containing protein. (389 aa)
	A0A182R7H2	Nas2_N domain-containing protein. (204 aa)
	A0A182R9S0	PCI domain-containing protein. (497 aa)
	A0A182RAC6	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (276 aa)
	A0A182RC23	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (249 aa)
	A0A182RE57	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (260 aa)
	A0A182REP1	Uncharacterized protein. (231 aa)
	A0A182RFD2	Proteasome subunit beta. (279 aa)
	A0A182RIL9	Proteasome subunit beta. (205 aa)
	A0A182RIN6	Proteasome subunit beta. (228 aa)
	A0A182RK71	MPN domain-containing protein. (311 aa)
	A0A182RLE0	PCI domain-containing protein. (262 aa)
	A0A182RLE9	Uncharacterized protein. (1921 aa)
	A0A182RMH0	VWFA domain-containing protein. (411 aa)
	A0A182RN14	PCI domain-containing protein. (460 aa)
	A0A182RNG2	AAA domain-containing protein; Belongs to the AAA ATPase family. (392 aa)
	A0A182RNR9	AAA domain-containing protein; Belongs to the AAA ATPase family. (412 aa)
	A0A182RPD3	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (1037 aa)
	A0A182RPF7	AAA domain-containing protein; Belongs to the AAA ATPase family. (428 aa)
	A0A182RPU2	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (234 aa)
	A0A182RPW6	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (253 aa)
	A0A182RQB3	Uncharacterized protein. (323 aa)
	A0A182RTE5	AAA domain-containing protein; Belongs to the AAA ATPase family. (434 aa)
	A0A182RW77	Proteasome subunit beta. (284 aa)
	A0A182RW83	MPN domain-containing protein. (177 aa)
	A0A182RWD6	UAS domain-containing protein. (534 aa)
	A0A182RX91	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (242 aa)
	A0A182RY12	AAA domain-containing protein; Belongs to the AAA ATPase family. (432 aa)
	A0A182RY65	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (246 aa)
	A0A182RYY5	Uncharacterized protein. (1910 aa)
	A0A1Y9HDY5	Proteasome 26S non-ATPase subunit. (416 aa)
	A0A4Y0BG84	PCI domain-containing protein. (416 aa)
	A0A4Y0BGY7	AAA domain-containing protein; Belongs to the AAA ATPase family. (438 aa)
	A0A4Y0BHX9	Ubiquitin carboxyl-terminal hydrolase. (511 aa)
	A0A4Y0BLD9	Uncharacterized protein. (264 aa)
	A0A4Y0BNV0	Uncharacterized protein. (525 aa)
	A0A4Y0BQ44	Proteasome subunit beta; Belongs to the peptidase T1B family. (272 aa)
	A0A4Y0BQH3	RPN13_C domain-containing protein. (460 aa)
	A0A4Y0BRV9	PCI domain-containing protein. (380 aa)
	A0A4Y0BSS2	AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A182R1X9	A0A182R3V0	MPN domain-containing protein.	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.	0.994
A0A182R1X9	A0A182R489	MPN domain-containing protein.	MPN domain-containing protein.	0.980
A0A182R1X9	A0A182R4A9	MPN domain-containing protein.	Proteasome subunit beta.	0.988
A0A182R1X9	A0A182R513	MPN domain-containing protein.	Uncharacterized protein.	0.972
A0A182R1X9	A0A182R676	MPN domain-containing protein.	PCI domain-containing protein.	0.995
A0A182R1X9	A0A182R7H2	MPN domain-containing protein.	Nas2_N domain-containing protein.	0.850
A0A182R1X9	A0A182R9S0	MPN domain-containing protein.	PCI domain-containing protein.	0.994
A0A182R1X9	A0A182RAC6	MPN domain-containing protein.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.987
A0A182R1X9	A0A182RC23	MPN domain-containing protein.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.993
A0A182R1X9	A0A182RE57	MPN domain-containing protein.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.993
A0A182R1X9	A0A182REP1	MPN domain-containing protein.	Uncharacterized protein.	0.988
A0A182R1X9	A0A182RFD2	MPN domain-containing protein.	Proteasome subunit beta.	0.985
A0A182R1X9	A0A182RIL9	MPN domain-containing protein.	Proteasome subunit beta.	0.988
A0A182R1X9	A0A182RIN6	MPN domain-containing protein.	Proteasome subunit beta.	0.985
A0A182R1X9	A0A182RK71	MPN domain-containing protein.	MPN domain-containing protein.	0.996
A0A182R1X9	A0A182RLE0	MPN domain-containing protein.	PCI domain-containing protein.	0.995
A0A182R1X9	A0A182RLE9	MPN domain-containing protein.	Uncharacterized protein.	0.769
A0A182R1X9	A0A182RMH0	MPN domain-containing protein.	VWFA domain-containing protein.	0.994
A0A182R1X9	A0A182RN14	MPN domain-containing protein.	PCI domain-containing protein.	0.998
A0A182R1X9	A0A182RNG2	MPN domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.994