76 items (Anopheles funestus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A4Y0BDX3	Uncharacterized protein. (421 aa)
	A0A4Y0BFS6	Regnase_1_C domain-containing protein. (225 aa)
	A0A4Y0BFV6	GIY-YIG domain-containing protein. (184 aa)
	A0A4Y0BGM7	Uncharacterized protein; Belongs to the argonaute family. (891 aa)
	A0A4Y0BGU0	Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (286 aa)
	A0A4Y0BH05	Uncharacterized protein. (732 aa)
	A0A182R5J7	Uncharacterized protein. (95 aa)
	A0A182R6N9	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (649 aa)
	A0A182R6P7	DBR1 domain-containing protein. (511 aa)
	A0A182R8R6	PLDc_2 domain-containing protein. (240 aa)
	A0A182RA43	C3H1-type domain-containing protein. (811 aa)
	A0A182RAL5	Endonuclease_NS domain-containing protein. (397 aa)
	A0A182RAR8	RNase_Zc3h12a domain-containing protein. (213 aa)
	A0A182RCZ1	Uncharacterized protein; Belongs to the argonaute family. (846 aa)
	A0A182RD28	Uncharacterized protein; Belongs to the argonaute family. (1169 aa)
	A0A182RDC6	Uncharacterized protein. (122 aa)
	A0A182RE24	Uncharacterized protein. (410 aa)
	A0A182REC8	ANK_REP_REGION domain-containing protein. (654 aa)
	Fen1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (383 aa)
	A0A182RGC8	tRNA_int_endo domain-containing protein. (283 aa)
	A0A182RGE8	Uncharacterized protein; Belongs to the argonaute family. (892 aa)
	A0A182R306	Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (387 aa)
	A0A182RH57	Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family. (356 aa)
	A0A182RHT0	RNase_Zc3h12a domain-containing protein. (491 aa)
	A0A182RIU6	Uncharacterized protein. (391 aa)
	A0A182RJD0	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (330 aa)
	A0A4Y0BHQ8	Uncharacterized protein. (245 aa)
	A0A4Y0BI95	Uncharacterized protein; Belongs to the helicase family. Dicer subfamily. (974 aa)
	A0A4Y0BJP1	DBR1 domain-containing protein. (562 aa)
	A0A4Y0BJR0	Uncharacterized protein; Belongs to the argonaute family. (949 aa)
	A0A4Y0BKK4	Uncharacterized protein. (236 aa)
	A0A4Y0BL39	Uncharacterized protein. (129 aa)
	A0A4Y0BLM3	RNase III domain-containing protein. (416 aa)
	A0A4Y0BLN2	PINc domain-containing protein. (1563 aa)
	A0A4Y0BLT7	Alba domain-containing protein. (177 aa)
	A0A4Y0BLV8	Uncharacterized protein. (376 aa)
	A0A4Y0BPR9	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. (646 aa)
	A0A4Y0BPZ7	PRORP domain-containing protein. (515 aa)
	A0A4Y0BQ93	XendoU domain-containing protein. (531 aa)
	A0A4Y0BQK8	Endonuclease_NS domain-containing protein. (397 aa)
	A0A4Y0BQP0	Uncharacterized protein. (1145 aa)
	A0A4Y0BW18	Endonuclease_NS domain-containing protein. (452 aa)
	A0A182R3T2	Uncharacterized protein. (830 aa)
	A0A182R3W6	CIDE-N domain-containing protein. (421 aa)
	A0A182R493	Uncharacterized protein; Belongs to the argonaute family. (920 aa)
	A0A182R4B0	ERCC4 domain-containing protein. (480 aa)
	A0A182R4C6	Uncharacterized protein. (386 aa)
	A0A182R4N6	ERCC4 domain-containing protein. (1041 aa)
	A0A182R5E4	Uncharacterized protein; Belongs to the helicase family. Dicer subfamily. (1683 aa)
	A0A182R3R0	RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (452 aa)
	A0A182RPL1	Uncharacterized protein. (2315 aa)
	A0A182RKD7	Endonuclease_NS domain-containing protein. (430 aa)
	A0A182RLB6	Uncharacterized protein. (319 aa)
	A0A182RM05	Uncharacterized protein. (1384 aa)
	A0A182RMM4	Uncharacterized protein. (552 aa)
	A0A182R3A9	Endonuclease. (318 aa)
	A0A182RPT5	PINc domain-containing protein. (655 aa)
	A0A182RQM2	Uncharacterized protein. (735 aa)
	A0A182RR95	Uncharacterized protein. (609 aa)
	A0A182RRZ6	Uncharacterized protein. (164 aa)
	A0A182RS86	Uncharacterized protein. (1151 aa)
	A0A182RSD2	Uncharacterized protein. (690 aa)
	A0A182RT02	Uncharacterized protein. (295 aa)
	A0A182RT41	RNase H domain-containing protein. (362 aa)
	A0A182RTC0	Uncharacterized protein. (578 aa)
	A0A182RUK6	Uncharacterized protein. (424 aa)
	A0A182RV61	Lactamase_B domain-containing protein. (153 aa)
	A0A182RX07	Uncharacterized protein; Belongs to the RNR ribonuclease family. (961 aa)
	A0A182RZ53	DRMBL domain-containing protein. (403 aa)
	A0A182RZI1	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (315 aa)
	A0A182RZK4	Uncharacterized protein. (855 aa)
	A0A182S4S7	Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (287 aa)
	A0A182S4S9	RNase H domain-containing protein. (168 aa)
	A0A1I8JUJ8	tRNA-splicing endonuclease subunit Sen54. (397 aa)
	A0A1I8JUQ3	Uncharacterized protein. (1124 aa)
	A0A4Y0ARF5	C3H1-type domain-containing protein. (927 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A182R306	A0A182RZI1	A0A182R306	A0A182RZI1	Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs.	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10.	0.917
A0A182R306	A0A1I8JUQ3	A0A182R306	A0A1I8JUQ3	Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs.	Uncharacterized protein.	0.565
A0A182R3A9	A0A182R3T2	A0A182R3A9	A0A182R3T2	Endonuclease.	Uncharacterized protein.	0.971
A0A182R3A9	A0A182RM05	A0A182R3A9	A0A182RM05	Endonuclease.	Uncharacterized protein.	0.538
A0A182R3A9	A0A182RQM2	A0A182R3A9	A0A182RQM2	Endonuclease.	Uncharacterized protein.	0.659
A0A182R3A9	A0A182RS86	A0A182R3A9	A0A182RS86	Endonuclease.	Uncharacterized protein.	0.418
A0A182R3A9	A0A182RZK4	A0A182R3A9	A0A182RZK4	Endonuclease.	Uncharacterized protein.	0.538
A0A182R3A9	A0A4Y0BLV8	A0A182R3A9	A0A4Y0BLV8	Endonuclease.	Uncharacterized protein.	0.400
A0A182R3A9	Fen1	A0A182R3A9	A0A182RFB4	Endonuclease.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.741
A0A182R3R0	A0A182RIU6	A0A182R3R0	A0A182RIU6	RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family.	Uncharacterized protein.	0.891
A0A182R3R0	A0A182RRZ6	A0A182R3R0	A0A182RRZ6	RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family.	Uncharacterized protein.	0.484
A0A182R3R0	A0A182RZI1	A0A182R3R0	A0A182RZI1	RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family.	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10.	0.532
A0A182R3R0	A0A4Y0BPR9	A0A182R3R0	A0A4Y0BPR9	RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family.	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.	0.489
A0A182R3T2	A0A182R3A9	A0A182R3T2	A0A182R3A9	Uncharacterized protein.	Endonuclease.	0.971
A0A182R3T2	A0A182RJD0	A0A182R3T2	A0A182RJD0	Uncharacterized protein.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.644
A0A182R3T2	A0A182RR95	A0A182R3T2	A0A182RR95	Uncharacterized protein.	Uncharacterized protein.	0.409
A0A182R3T2	A0A182RRZ6	A0A182R3T2	A0A182RRZ6	Uncharacterized protein.	Uncharacterized protein.	0.598
A0A182R3T2	A0A182RSD2	A0A182R3T2	A0A182RSD2	Uncharacterized protein.	Uncharacterized protein.	0.483
A0A182R3T2	A0A182RTC0	A0A182R3T2	A0A182RTC0	Uncharacterized protein.	Uncharacterized protein.	0.435
A0A182R3T2	A0A182RV61	A0A182R3T2	A0A182RV61	Uncharacterized protein.	Lactamase_B domain-containing protein.	0.632