36 items (Anopheles funestus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A4Y0BEE5	AAA domain-containing protein. (348 aa)
	A0A182RPL3	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
	A0A182RSJ8	Uncharacterized protein. (455 aa)
	A0A182RNG5	UmuC domain-containing protein. (710 aa)
	A0A182RA20	CDT1 domain-containing protein. (747 aa)
	A0A182RSN2	Protein kinase domain-containing protein. (582 aa)
	A0A182R5J9	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (566 aa)
	A0A182R723	ANK_REP_REGION domain-containing protein. (1529 aa)
	A0A182R7S6	Uncharacterized protein. (120 aa)
	A0A182R8E4	RECA_2 domain-containing protein. (262 aa)
	A0A4Y0AV06	BRCT domain-containing protein. (1575 aa)
	A0A182S4V9	Uncharacterized protein. (335 aa)
	A0A182S019	Rad51 domain-containing protein. (310 aa)
	A0A182RZQ7	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1178 aa)
	A0A182RXH3	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (429 aa)
	A0A182R8X4	Uncharacterized protein. (1992 aa)
	A0A182R410	Mcm10 domain-containing protein. (794 aa)
	A0A182RXB5	AAA domain-containing protein. (360 aa)
	A0A182R4E9	DNA_pol_B domain-containing protein. (184 aa)
	A0A182RWG0	Rep_fac_C domain-containing protein. (358 aa)
	A0A182RG25	Uncharacterized protein; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (720 aa)
	A0A182RI42	Uncharacterized protein. (134 aa)
	A0A182RI43	DNA_pol_E_B domain-containing protein. (490 aa)
	A0A182RJY6	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (287 aa)
	A0A182RTR4	AAA domain-containing protein. (327 aa)
	PIF1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (672 aa)
	A0A182RD86	DNA polymerase. (1552 aa)
	A0A182RDL1	RECA_2 domain-containing protein. (329 aa)
	A0A182RDN7	Uncharacterized protein. (465 aa)
	A0A182REJ3	Uncharacterized protein. (1323 aa)
	A0A182RME0	TIMELESS domain-containing protein. (1296 aa)
	A0A182RVP3	Uncharacterized protein. (1075 aa)
	A0A182RVQ9	Replication factor C subunit 1. (1051 aa)
	A0A4Y0BPQ4	MCM_lid domain-containing protein. (251 aa)
	A0A4Y0BP46	Uncharacterized protein. (1012 aa)
	A0A4Y0BGA9	DNA polymerase. (1092 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A182R410	A0A182R4E9	A0A182R410	A0A182R4E9	Mcm10 domain-containing protein.	DNA_pol_B domain-containing protein.	0.852
A0A182R410	A0A182R5J9	A0A182R410	A0A182R5J9	Mcm10 domain-containing protein.	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.	0.952
A0A182R410	A0A182R7S6	A0A182R410	A0A182R7S6	Mcm10 domain-containing protein.	Uncharacterized protein.	0.747
A0A182R410	A0A182RA20	A0A182R410	A0A182RA20	Mcm10 domain-containing protein.	CDT1 domain-containing protein.	0.994
A0A182R410	A0A182RD86	A0A182R410	A0A182RD86	Mcm10 domain-containing protein.	DNA polymerase.	0.982
A0A182R410	A0A182RDL1	A0A182R410	A0A182RDL1	Mcm10 domain-containing protein.	RECA_2 domain-containing protein.	0.569
A0A182R410	A0A182REJ3	A0A182R410	A0A182REJ3	Mcm10 domain-containing protein.	Uncharacterized protein.	0.757
A0A182R410	A0A182RI42	A0A182R410	A0A182RI42	Mcm10 domain-containing protein.	Uncharacterized protein.	0.824
A0A182R410	A0A182RI43	A0A182R410	A0A182RI43	Mcm10 domain-containing protein.	DNA_pol_E_B domain-containing protein.	0.833
A0A182R410	A0A182RJY6	A0A182R410	A0A182RJY6	Mcm10 domain-containing protein.	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.834
A0A182R410	A0A182RME0	A0A182R410	A0A182RME0	Mcm10 domain-containing protein.	TIMELESS domain-containing protein.	0.621
A0A182R410	A0A182RPL3	A0A182R410	A0A182RPL3	Mcm10 domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.806
A0A182R410	A0A182RSN2	A0A182R410	A0A182RSN2	Mcm10 domain-containing protein.	Protein kinase domain-containing protein.	0.515
A0A182R410	A0A182RTR4	A0A182R410	A0A182RTR4	Mcm10 domain-containing protein.	AAA domain-containing protein.	0.514
A0A182R410	A0A182RVQ9	A0A182R410	A0A182RVQ9	Mcm10 domain-containing protein.	Replication factor C subunit 1.	0.569
A0A182R410	A0A182RWG0	A0A182R410	A0A182RWG0	Mcm10 domain-containing protein.	Rep_fac_C domain-containing protein.	0.807
A0A182R410	A0A182RXB5	A0A182R410	A0A182RXB5	Mcm10 domain-containing protein.	AAA domain-containing protein.	0.418
A0A182R410	A0A182RXH3	A0A182R410	A0A182RXH3	Mcm10 domain-containing protein.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.938
A0A182R410	A0A4Y0BEE5	A0A182R410	A0A4Y0BEE5	Mcm10 domain-containing protein.	AAA domain-containing protein.	0.418
A0A182R410	A0A4Y0BGA9	A0A182R410	A0A4Y0BGA9	Mcm10 domain-containing protein.	DNA polymerase.	0.852