53 items (Anopheles funestus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A182R1J3	MCM domain-containing protein; Belongs to the MCM family. (1095 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (717 aa)
	A0A182R3T5	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. (472 aa)
	A0A182R3U9	AN1-type domain-containing protein. (177 aa)
	A0A182R4W6	Helicase ATP-binding domain-containing protein. (909 aa)
	A0A182R5D9	Uncharacterized protein. (1188 aa)
	A0A182R6W1	DNA helicase; Belongs to the MCM family. (812 aa)
	A0A182R700	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (660 aa)
	A0A182R7K0	Uncharacterized protein. (1384 aa)
	A0A182R893	Uncharacterized protein. (767 aa)
	A0A182R947	Uncharacterized protein. (1100 aa)
	A0A182RA52	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (819 aa)
	A0A182RE53	DNA helicase; Belongs to the MCM family. (876 aa)
	A0A182RF05	Uncharacterized protein. (1628 aa)
	A0A182RG11	DNA helicase; Belongs to the MCM family. (822 aa)
	A0A182RG13	Uncharacterized protein. (1157 aa)
	A0A182RG25	Uncharacterized protein; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (720 aa)
	A0A182RH19	Uncharacterized protein. (1286 aa)
	A0A182RI25	DNA helicase; Belongs to the MCM family. (733 aa)
	A0A182RIW4	FHA domain-containing protein. (772 aa)
	A0A182RKX7	Uncharacterized protein. (804 aa)
	A0A182RMV3	Regulator of telomere elongation helicase 1 homolog; ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. (977 aa)
	A0A182RNA9	Uncharacterized protein. (1459 aa)
	A0A182RNF2	Uncharacterized protein. (1979 aa)
	A0A182RPL3	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
	A0A182RR13	PHD-type domain-containing protein. (1675 aa)
	A0A4Y0AQP3	Uncharacterized protein. (1300 aa)
	A0A1Y9HF49	ATP-dependent RNA helicase DHX36. (1057 aa)
	A0A1Y9HER1	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. (456 aa)
	A0A182RXG1	Uncharacterized protein. (728 aa)
	A0A182RX78	DNA helicase; Belongs to the MCM family. (899 aa)
	A0A182RWH0	Uncharacterized protein. (819 aa)
	A0A182RW75	SF4 helicase domain-containing protein. (684 aa)
	PIF1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (672 aa)
	A0A182RTH7	Ku domain-containing protein. (622 aa)
	A0A182RT65	Helicase ATP-binding domain-containing protein. (759 aa)
	A0A182RSB9	Uncharacterized protein. (2183 aa)
	A0A182RS86	Uncharacterized protein. (1151 aa)
	A0A4Y0ARG3	Uncharacterized protein. (1513 aa)
	A0A4Y0B5Z4	Uncharacterized protein. (116 aa)
	A0A4Y0BCU1	SF4 helicase domain-containing protein. (684 aa)
	A0A4Y0BE92	Uncharacterized protein. (817 aa)
	A0A4Y0BEY3	Uncharacterized protein. (711 aa)
	A0A4Y0BG79	Uncharacterized protein. (463 aa)
	A0A4Y0BIR8	Uncharacterized protein. (334 aa)
	A0A4Y0BJ98	Uncharacterized protein. (272 aa)
	A0A4Y0BKX8	Uncharacterized protein. (817 aa)
	A0A4Y0BPQ4	MCM_lid domain-containing protein. (251 aa)
	A0A4Y0BQ50	Ku domain-containing protein. (728 aa)
	A0A4Y0BSP6	Uncharacterized protein. (138 aa)
	A0A4Y0BTX5	MCM domain-containing protein; Belongs to the MCM family. (832 aa)
	A0A182RRS7	Zinc-hook domain-containing protein. (1308 aa)
	A0A182RRB4	Uncharacterized protein. (141 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A182R1J3	A0A182R4W6	A0A182R1J3	A0A182R4W6	MCM domain-containing protein; Belongs to the MCM family.	Helicase ATP-binding domain-containing protein.	0.499
A0A182R1J3	A0A182R6W1	A0A182R1J3	A0A182R6W1	MCM domain-containing protein; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.982
A0A182R1J3	A0A182RA52	A0A182R1J3	A0A182RA52	MCM domain-containing protein; Belongs to the MCM family.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.414
A0A182R1J3	A0A182RE53	A0A182R1J3	A0A182RE53	MCM domain-containing protein; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.997
A0A182R1J3	A0A182RF05	A0A182R1J3	A0A182RF05	MCM domain-containing protein; Belongs to the MCM family.	Uncharacterized protein.	0.498
A0A182R1J3	A0A182RG11	A0A182R1J3	A0A182RG11	MCM domain-containing protein; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.997
A0A182R1J3	A0A182RI25	A0A182R1J3	A0A182RI25	MCM domain-containing protein; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.997
A0A182R1J3	A0A182RNA9	A0A182R1J3	A0A182RNA9	MCM domain-containing protein; Belongs to the MCM family.	Uncharacterized protein.	0.498
A0A182R1J3	A0A182RPL3	A0A182R1J3	A0A182RPL3	MCM domain-containing protein; Belongs to the MCM family.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.956
A0A182R1J3	A0A182RWH0	A0A182R1J3	A0A182RWH0	MCM domain-containing protein; Belongs to the MCM family.	Uncharacterized protein.	0.516
A0A182R1J3	A0A1Y9HER1	A0A182R1J3	A0A1Y9HER1	MCM domain-containing protein; Belongs to the MCM family.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.	0.473
A0A182R1J3	A0A4Y0ARG3	A0A182R1J3	A0A4Y0ARG3	MCM domain-containing protein; Belongs to the MCM family.	Uncharacterized protein.	0.414
A0A182R1J3	A0A4Y0BPQ4	A0A182R1J3	A0A4Y0BPQ4	MCM domain-containing protein; Belongs to the MCM family.	MCM_lid domain-containing protein.	0.985
A0A182R1J3	A0A4Y0BTX5	A0A182R1J3	A0A4Y0BTX5	MCM domain-containing protein; Belongs to the MCM family.	MCM domain-containing protein; Belongs to the MCM family.	0.985
A0A182R1J3	MCM7	A0A182R1J3	A0A182R292	MCM domain-containing protein; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.997
A0A182R3T5	A0A182R6W1	A0A182R3T5	A0A182R6W1	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.	DNA helicase; Belongs to the MCM family.	0.441
A0A182R3T5	A0A182RE53	A0A182R3T5	A0A182RE53	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.	DNA helicase; Belongs to the MCM family.	0.465
A0A182R3T5	A0A182RG11	A0A182R3T5	A0A182RG11	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.	DNA helicase; Belongs to the MCM family.	0.513
A0A182R3T5	A0A182RG13	A0A182R3T5	A0A182RG13	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.	Uncharacterized protein.	0.612
A0A182R3T5	A0A182RG25	A0A182R3T5	A0A182RG25	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.	Uncharacterized protein; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	0.696