50 items (Anopheles funestus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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Your Input:
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (717 aa)
	A0A182R4E9	DNA_pol_B domain-containing protein. (184 aa)
	A0A182R5J9	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (566 aa)
	A0A182R7S6	Uncharacterized protein. (120 aa)
	A0A182R8U1	Histone H2A; Belongs to the histone H2A family. (125 aa)
	A0A182RAI7	Uncharacterized protein. (413 aa)
	A0A182RC85	Histone domain-containing protein. (248 aa)
	A0A182RD86	DNA polymerase. (1552 aa)
	A0A182RDN7	Uncharacterized protein. (465 aa)
	A0A182RE53	DNA helicase; Belongs to the MCM family. (876 aa)
	A0A182RG11	DNA helicase; Belongs to the MCM family. (822 aa)
	A0A182RI25	DNA helicase; Belongs to the MCM family. (733 aa)
	A0A182RI42	Uncharacterized protein. (134 aa)
	A0A182RI43	DNA_pol_E_B domain-containing protein. (490 aa)
	A0A182RL37	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	A0A182RM67	Histone H2A; Belongs to the histone H2A family. (126 aa)
	A0A182RP06	Histone H3; Belongs to the histone H3 family. (136 aa)
	A0A182RPL3	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
	A0A182RPN5	Uncharacterized protein. (133 aa)
	A0A182RQV7	Histone H2B; Belongs to the histone H2B family. (124 aa)
	A0A182RRB4	Uncharacterized protein. (141 aa)
	A0A182RRD7	ORC_WH_C domain-containing protein. (699 aa)
	A0A182RSJ8	Uncharacterized protein. (455 aa)
	A0A182RT07	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (3108 aa)
	A0A182RTD4	WD_REPEATS_REGION domain-containing protein. (1746 aa)
	A0A182RUT9	Histone H3; Belongs to the histone H3 family. (136 aa)
	A0A182RW43	Sld5 domain-containing protein. (203 aa)
	A0A182RWN4	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (205 aa)
	A0A182RX78	DNA helicase; Belongs to the MCM family. (899 aa)
	A0A182RXH3	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (429 aa)
	A0A182RXT7	Uncharacterized protein. (569 aa)
	A0A182S431	Uncharacterized protein. (194 aa)
	A0A182S4N1	Histone H3; Belongs to the histone H3 family. (136 aa)
	A0A182S4N2	Histone H2A; Belongs to the histone H2A family. (124 aa)
	A0A182S4N4	Histone H3; Belongs to the histone H3 family. (79 aa)
	A0A1D6TC74	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	A0A1D6TCF8	Histone H3; Belongs to the histone H3 family. (79 aa)
	A0A4Y0B5Z4	Uncharacterized protein. (116 aa)
	A0A4Y0BE92	Uncharacterized protein. (817 aa)
	A0A4Y0BFG3	Uncharacterized protein. (413 aa)
	A0A4Y0BG62	Uncharacterized protein. (84 aa)
	A0A4Y0BGA9	DNA polymerase. (1092 aa)
	A0A4Y0BHN1	TFIIB-type domain-containing protein. (670 aa)
	A0A4Y0BKX8	Uncharacterized protein. (817 aa)
	A0A4Y0BPQ4	MCM_lid domain-containing protein. (251 aa)
	A0A4Y0BPY9	TFIIB-type domain-containing protein. (311 aa)
	A0A4Y0BQ50	Ku domain-containing protein. (728 aa)
	A0A4Y0BQ78	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (237 aa)
	A0A4Y0BQH8	Uncharacterized protein. (347 aa)
	A0A4Y0BVG7	TFIIB-type domain-containing protein. (316 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A182R4E9	A0A182R5J9	A0A182R4E9	A0A182R5J9	DNA_pol_B domain-containing protein.	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.	0.976
A0A182R4E9	A0A182R7S6	A0A182R4E9	A0A182R7S6	DNA_pol_B domain-containing protein.	Uncharacterized protein.	0.768
A0A182R4E9	A0A182RD86	A0A182R4E9	A0A182RD86	DNA_pol_B domain-containing protein.	DNA polymerase.	0.947
A0A182R4E9	A0A182RDN7	A0A182R4E9	A0A182RDN7	DNA_pol_B domain-containing protein.	Uncharacterized protein.	0.971
A0A182R4E9	A0A182RE53	A0A182R4E9	A0A182RE53	DNA_pol_B domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.973
A0A182R4E9	A0A182RG11	A0A182R4E9	A0A182RG11	DNA_pol_B domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.976
A0A182R4E9	A0A182RI25	A0A182R4E9	A0A182RI25	DNA_pol_B domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.984
A0A182R4E9	A0A182RI42	A0A182R4E9	A0A182RI42	DNA_pol_B domain-containing protein.	Uncharacterized protein.	0.942
A0A182R4E9	A0A182RI43	A0A182R4E9	A0A182RI43	DNA_pol_B domain-containing protein.	DNA_pol_E_B domain-containing protein.	0.946
A0A182R4E9	A0A182RPL3	A0A182R4E9	A0A182RPL3	DNA_pol_B domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.902
A0A182R4E9	A0A182RQV7	A0A182R4E9	A0A182RQV7	DNA_pol_B domain-containing protein.	Histone H2B; Belongs to the histone H2B family.	0.427
A0A182R4E9	A0A182RRD7	A0A182R4E9	A0A182RRD7	DNA_pol_B domain-containing protein.	ORC_WH_C domain-containing protein.	0.598
A0A182R4E9	A0A182RSJ8	A0A182R4E9	A0A182RSJ8	DNA_pol_B domain-containing protein.	Uncharacterized protein.	0.997
A0A182R4E9	A0A182RW43	A0A182R4E9	A0A182RW43	DNA_pol_B domain-containing protein.	Sld5 domain-containing protein.	0.713
A0A182R4E9	A0A182RWN4	A0A182R4E9	A0A182RWN4	DNA_pol_B domain-containing protein.	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.	0.805
A0A182R4E9	A0A182RX78	A0A182R4E9	A0A182RX78	DNA_pol_B domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.978
A0A182R4E9	A0A182RXH3	A0A182R4E9	A0A182RXH3	DNA_pol_B domain-containing protein.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.976
A0A182R4E9	A0A182RXT7	A0A182R4E9	A0A182RXT7	DNA_pol_B domain-containing protein.	Uncharacterized protein.	0.946
A0A182R4E9	A0A182S431	A0A182R4E9	A0A182S431	DNA_pol_B domain-containing protein.	Uncharacterized protein.	0.858
A0A182R4E9	A0A4Y0BE92	A0A182R4E9	A0A4Y0BE92	DNA_pol_B domain-containing protein.	Uncharacterized protein.	0.517