(15 nodes) Negative regulation of ERK1 and ERK2 cascade network (Anopheles funestus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	A0A4Y0AWQ8	Uncharacterized protein. (3003 aa)
	A0A4Y0BFZ0	Uncharacterized protein. (1082 aa)
	A0A4Y0BPV3	Uncharacterized protein. (469 aa)
	A0A4Y0BMV7	Uncharacterized protein. (356 aa)
	A0A4Y0BM58	Uncharacterized protein. (524 aa)
	A0A4Y0BM25	WH1 domain-containing protein. (380 aa)
	A0A182RW64	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1218 aa)
	A0A4Y0AN43	Uncharacterized protein. (695 aa)
	A0A182R2L5	Uncharacterized protein. (678 aa)
	A0A182RFY8	UBR-type domain-containing protein. (5515 aa)
	A0A182RGF0	Uncharacterized protein. (3127 aa)
	A0A182RNN3	Non-specific serine/threonine protein kinase. (588 aa)
	A0A182RP56	Uncharacterized protein. (2134 aa)
	A0A182RRU5	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
	A0A182RW42	ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (172 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A182R2L5	A0A182RP56	Uncharacterized protein.	Uncharacterized protein.	0.447
A0A182R2L5	A0A4Y0BFZ0	Uncharacterized protein.	Uncharacterized protein.	0.614
A0A182RFY8	A0A182RGF0	UBR-type domain-containing protein.	Uncharacterized protein.	0.475
A0A182RFY8	A0A4Y0AWQ8	UBR-type domain-containing protein.	Uncharacterized protein.	0.475
A0A182RGF0	A0A182RFY8	Uncharacterized protein.	UBR-type domain-containing protein.	0.475
A0A182RP56	A0A182R2L5	Uncharacterized protein.	Uncharacterized protein.	0.447
A0A182RP56	A0A4Y0AN43	Uncharacterized protein.	Uncharacterized protein.	0.447
A0A182RP56	A0A4Y0BFZ0	Uncharacterized protein.	Uncharacterized protein.	0.614
A0A182RW64	A0A4Y0BFZ0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Uncharacterized protein.	0.855
A0A182RW64	A0A4Y0BM58	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Uncharacterized protein.	0.442
A0A182RW64	A0A4Y0BPV3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Uncharacterized protein.	0.500
A0A4Y0AN43	A0A182RP56	Uncharacterized protein.	Uncharacterized protein.	0.447
A0A4Y0AN43	A0A4Y0BFZ0	Uncharacterized protein.	Uncharacterized protein.	0.614
A0A4Y0AWQ8	A0A182RFY8	Uncharacterized protein.	UBR-type domain-containing protein.	0.475
A0A4Y0BFZ0	A0A182R2L5	Uncharacterized protein.	Uncharacterized protein.	0.614
A0A4Y0BFZ0	A0A182RP56	Uncharacterized protein.	Uncharacterized protein.	0.614
A0A4Y0BFZ0	A0A182RW64	Uncharacterized protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.855
A0A4Y0BFZ0	A0A4Y0AN43	Uncharacterized protein.	Uncharacterized protein.	0.614
A0A4Y0BFZ0	A0A4Y0BMV7	Uncharacterized protein.	Uncharacterized protein.	0.994
A0A4Y0BFZ0	A0A4Y0BPV3	Uncharacterized protein.	Uncharacterized protein.	0.488