(73 nodes) Proton transmembrane transport network (Anopheles funestus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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experimentally determined

Predicted Interactions

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Your Input:
	A0A1I8JUY2	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (95 aa)
	A0A182R367	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (127 aa)
	A0A182R386	Uncharacterized protein. (1069 aa)
	A0A182R3B2	ATP-synt_DE_N domain-containing protein. (160 aa)
	A0A182R3G5	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (348 aa)
	A0A182R3M5	Uncharacterized protein. (226 aa)
	A0A182R3S6	Anion exchange protein. (1214 aa)
	A0A182R405	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (666 aa)
	A0A182R584	Uncharacterized protein. (652 aa)
	A0A182R585	Uncharacterized protein. (612 aa)
	A0A182R586	Uncharacterized protein. (514 aa)
	A0A182R704	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (331 aa)
	A0A182R7J9	Oxidored_q6 domain-containing protein; Belongs to the complex I 20 kDa subunit family. (207 aa)
	A0A182R825	Vacuolar H+ ATPase M8.9 accessory subunit. (323 aa)
	A0A182R8A5	Uncharacterized protein. (1119 aa)
	A0A182R8D8	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (864 aa)
	A0A182R9C8	Uncharacterized protein. (56 aa)
	A0A182RA96	Letm1 RBD domain-containing protein. (381 aa)
	A0A182RAQ9	Aa_trans domain-containing protein. (569 aa)
	A0A182RAU3	Uncharacterized protein; Belongs to the V-ATPase proteolipid subunit family. (208 aa)
	A0A182RDX4	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (347 aa)
	A0A182RGA3	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (688 aa)
	A0A182RGC9	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (475 aa)
	A0A182RHP8	Uncharacterized protein. (56 aa)
	A0A182RIX7	Oxidored_q6 domain-containing protein; Belongs to the complex I 20 kDa subunit family. (206 aa)
	A0A182RJK6	Cytochrome c domain-containing protein. (306 aa)
	A0A182RJL3	Uncharacterized protein. (532 aa)
	A0A182RJV0	Uncharacterized protein. (107 aa)
	A0A182RJY8	Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (267 aa)
	A0A182RL51	Uncharacterized protein. (691 aa)
	A0A182RLU4	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (157 aa)
	A0A182RP13	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (116 aa)
	A0A182RPK1	Uncharacterized protein. (246 aa)
	A0A182RPN0	Uncharacterized protein. (210 aa)
	A0A182RQ21	Sodium/potassium-transporting ATPase subunit alpha. (1034 aa)
	A0A182RQ39	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (498 aa)
	A0A182RQ45	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
	A0A182RTL6	Uncharacterized protein. (58 aa)
	A0A182RTQ3	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (551 aa)
	A0A182RW42	ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (172 aa)
	A0A182RWF1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (586 aa)
	A0A182RX38	Na_H_Exchanger domain-containing protein. (643 aa)
	A0A182RXM9	ATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (138 aa)
	A0A182RYA8	Uncharacterized protein. (614 aa)
	A0A182RYU7	Uncharacterized protein. (970 aa)
	A0A182RZ07	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (388 aa)
	A0A182RZ32	Uncharacterized protein. (701 aa)
	A0A182S4R2	Uncharacterized protein. (82 aa)
	Q06DF7_ANOFN	Mitochondrial F1F0-ATP synthase subunit c; Belongs to the ATPase C chain family. (138 aa)
	A0A1Y9HEC8	Uncharacterized protein. (520 aa)
	A0A1Y9HEM0	Solute carrier family 45, member 1/2/4. (555 aa)
	A0A453YNN5	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
	A0A453YNR9	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (806 aa)
	A0A4Y0ALC9	Anion exchange protein. (1199 aa)
	A0A4Y0ALR8	Anion exchange protein. (1210 aa)
	A0A4Y0AML6	Uncharacterized protein. (656 aa)
	A0A4Y0AQ60	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (852 aa)
	A0A4Y0AVV7	V-ATPase_H_C domain-containing protein. (551 aa)
	A0A4Y0B268	Sodium/potassium-transporting ATPase subunit alpha. (1000 aa)
	A0A4Y0B284	Sodium/potassium-transporting ATPase subunit alpha. (1000 aa)
	A0A4Y0B2M5	Sodium/potassium-transporting ATPase subunit alpha. (1000 aa)
	A0A4Y0B4W7	Sodium/potassium-transporting ATPase subunit alpha. (1000 aa)
	A0A4Y0B7E0	ATP-synt_C domain-containing protein. (220 aa)
	A0A4Y0BEQ1	ATP-synt_ab domain-containing protein. (183 aa)
	A0A4Y0BK63	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (1213 aa)
	A0A4Y0BKX1	Uncharacterized protein. (1027 aa)
	A0A4Y0BLS9	Uncharacterized protein. (951 aa)
	A0A4Y0BNS3	Uncharacterized protein. (791 aa)
	A0A4Y0BP05	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (1129 aa)
	A0A4Y0BQE5	Uncharacterized protein. (911 aa)
	A0A4Y0BQQ4	Uncharacterized protein. (784 aa)
	A0A4Y0BR18	Uncharacterized protein. (671 aa)
	A0A4Y0BUQ4	Uncharacterized protein. (905 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A182R367	A0A182R3B2	A0A182R367	A0A182R3B2	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	ATP-synt_DE_N domain-containing protein.	0.939
A0A182R367	A0A182R3G5	A0A182R367	A0A182R3G5	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	0.997
A0A182R367	A0A182R3M5	A0A182R367	A0A182R3M5	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Uncharacterized protein.	0.999
A0A182R367	A0A182R7J9	A0A182R367	A0A182R7J9	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Oxidored_q6 domain-containing protein; Belongs to the complex I 20 kDa subunit family.	0.579
A0A182R367	A0A182R825	A0A182R367	A0A182R825	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Vacuolar H+ ATPase M8.9 accessory subunit.	0.969
A0A182R367	A0A182R8A5	A0A182R367	A0A182R8A5	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Uncharacterized protein.	0.981
A0A182R367	A0A182R8D8	A0A182R367	A0A182R8D8	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.987
A0A182R367	A0A182R9C8	A0A182R367	A0A182R9C8	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Uncharacterized protein.	0.556
A0A182R367	A0A182RAU3	A0A182R367	A0A182RAU3	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Uncharacterized protein; Belongs to the V-ATPase proteolipid subunit family.	0.999
A0A182R367	A0A182RDX4	A0A182R367	A0A182RDX4	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	0.997
A0A182R367	A0A182RGC9	A0A182R367	A0A182RGC9	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.	0.996
A0A182R367	A0A182RHP8	A0A182R367	A0A182RHP8	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Uncharacterized protein.	0.556
A0A182R367	A0A182RIX7	A0A182R367	A0A182RIX7	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Oxidored_q6 domain-containing protein; Belongs to the complex I 20 kDa subunit family.	0.579
A0A182R367	A0A182RLU4	A0A182R367	A0A182RLU4	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.999
A0A182R367	A0A182RP13	A0A182R367	A0A182RP13	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.999
A0A182R367	A0A182RPK1	A0A182R367	A0A182RPK1	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Uncharacterized protein.	0.997
A0A182R367	A0A182RPN0	A0A182R367	A0A182RPN0	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Uncharacterized protein.	0.701
A0A182R367	A0A182RQ21	A0A182R367	A0A182RQ21	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Sodium/potassium-transporting ATPase subunit alpha.	0.457
A0A182R367	A0A182RQ39	A0A182R367	A0A182RQ39	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.999
A0A182R367	A0A182RQ45	A0A182R367	A0A182RQ45	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.999