(34 nodes) Aldolase-type TIM barrel network (Anopheles funestus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	A0A182RRK5	Uncharacterized protein. (608 aa)
	A0A182RJQ7	FMN hydroxy acid dehydrogenase domain-containing protein. (552 aa)
	A0A182RI89	Glutamine amidotransferase type-2 domain-containing protein. (2088 aa)
	A0A182RGZ9	Uncharacterized protein. (403 aa)
	A0A182RCD2	Alpha-galactosidase. (443 aa)
	A0A182RCA4	Uncharacterized protein. (333 aa)
	A0A182RCA3	Uncharacterized protein. (752 aa)
	A0A182RB21	Uncharacterized protein; Belongs to the DapA family. (284 aa)
	A0A182RA31	Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)
	A0A182R6K4	Uncharacterized protein. (310 aa)
	A0A182R6J2	tRNA-dihydrouridine(47) synthase [NAD(P)(+)]. (613 aa)
	A0A182R245	Uncharacterized protein. (499 aa)
	A0A182R2R7	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1196 aa)
	A0A182R608	Triosephosphate isomerase. (247 aa)
	A0A4Y0BR05	OMPdecase domain-containing protein. (496 aa)
	A0A4Y0BQP4	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (328 aa)
	A0A4Y0BNC3	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (336 aa)
	A0A1I8JU48	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
	A0A182S4V7	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (395 aa)
	A0A1I8JU59	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (363 aa)
	A0A1Y9HEN3	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (398 aa)
	A0A4Y0ASZ5	Uncharacterized protein. (298 aa)
	A0A4Y0BEB5	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (395 aa)
	A0A4Y0BEW2	Uncharacterized protein. (403 aa)
	A0A4Y0BI88	Elp3 domain-containing protein. (487 aa)
	A0A4Y0BIT2	Hyaluronidase. (366 aa)
	A0A4Y0BK78	Pyruvate carboxyltransferase domain-containing protein. (324 aa)
	A0A4Y0BKI9	OMPdecase domain-containing protein. (496 aa)
	A0A4Y0BM54	Elp3 domain-containing protein. (417 aa)
	A0A182RZ08	Alpha-galactosidase. (429 aa)
	A0A182RYX6	FMN hydroxy acid dehydrogenase domain-containing protein. (363 aa)
	A0A182RW44	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (512 aa)
	A0A182RT43	AFP-like domain-containing protein. (374 aa)
	A0A182RP99	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1041 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A182R245	A0A182R6J2	Uncharacterized protein.	tRNA-dihydrouridine(47) synthase [NAD(P)(+)].	0.434
A0A182R245	A0A182RGZ9	Uncharacterized protein.	Uncharacterized protein.	0.440
A0A182R245	A0A182RRK5	Uncharacterized protein.	Uncharacterized protein.	0.701
A0A182R245	A0A4Y0BEW2	Uncharacterized protein.	Uncharacterized protein.	0.440
A0A182R2R7	A0A182R608	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Triosephosphate isomerase.	0.578
A0A182R2R7	A0A182R6K4	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Uncharacterized protein.	0.424
A0A182R2R7	A0A182RA31	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family.	0.555
A0A182R2R7	A0A182RI89	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Glutamine amidotransferase type-2 domain-containing protein.	0.932
A0A182R2R7	A0A182RJQ7	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	FMN hydroxy acid dehydrogenase domain-containing protein.	0.757
A0A182R2R7	A0A182RW44	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	0.468
A0A182R2R7	A0A182RYX6	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	FMN hydroxy acid dehydrogenase domain-containing protein.	0.757
A0A182R2R7	A0A1I8JU48	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	0.412
A0A182R2R7	A0A1I8JU59	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	0.412
A0A182R2R7	A0A4Y0BK78	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Pyruvate carboxyltransferase domain-containing protein.	0.910
A0A182R2R7	A0A4Y0BNC3	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.	0.562
A0A182R2R7	A0A4Y0BQP4	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	0.546
A0A182R608	A0A182R2R7	Triosephosphate isomerase.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.578
A0A182R608	A0A182R6K4	Triosephosphate isomerase.	Uncharacterized protein.	0.972
A0A182R608	A0A182RA31	Triosephosphate isomerase.	Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family.	0.902
A0A182R608	A0A182RI89	Triosephosphate isomerase.	Glutamine amidotransferase type-2 domain-containing protein.	0.530