(31 nodes) Recognition of DNA damage by PCNA-containing replication complex network (Anopheles funestus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	A0A4Y0BKB4	Uncharacterized protein. (533 aa)
	A0A182RMA2	RPA_C domain-containing protein. (246 aa)
	A0A182RM23	USP domain-containing protein; Belongs to the peptidase C19 family. (899 aa)
	A0A182RJQ0	Uncharacterized protein. (206 aa)
	A0A182RFI3	40S ribosomal protein S27A. (156 aa)
	A0A182REM2	CBFD_NFYB_HMF domain-containing protein. (216 aa)
	A0A182REB2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (521 aa)
	A0A182REB1	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2225 aa)
	A0A182RDN7	Uncharacterized protein. (465 aa)
	A0A182RCM0	WD_REPEATS_REGION domain-containing protein. (793 aa)
	A0A182R7S6	Uncharacterized protein. (120 aa)
	A0A182R6W2	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	A0A182R4Q9	CULLIN_2 domain-containing protein; Belongs to the cullin family. (756 aa)
	A0A182R366	CPSF_A domain-containing protein. (1138 aa)
	A0A182RPL3	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
	A0A182RR05	WD_REPEATS_REGION domain-containing protein. (710 aa)
	A0A182RSN2	Protein kinase domain-containing protein. (582 aa)
	A0A182RTR4	AAA domain-containing protein. (327 aa)
	A0A182RUX4	CBFD_NFYB_HMF domain-containing protein. (129 aa)
	A0A182RV72	Uncharacterized protein. (2087 aa)
	A0A182RVQ9	Replication factor C subunit 1. (1051 aa)
	A0A182RWG0	Rep_fac_C domain-containing protein. (358 aa)
	A0A182RX16	RING-type domain-containing protein. (109 aa)
	A0A182RXB5	AAA domain-containing protein. (360 aa)
	A0A4Y0BEE5	AAA domain-containing protein. (348 aa)
	A0A4Y0BF84	Uncharacterized protein. (609 aa)
	A0A4Y0BGR5	Uncharacterized protein. (913 aa)
	A0A4Y0BI70	KxDL domain-containing protein. (254 aa)
	A0A4Y0BKQ4	KxDL domain-containing protein. (254 aa)
	A0A4Y0BQQ1	AAA domain-containing protein. (1411 aa)
	Q06DG5_ANOFN	60S ribosomal protein L40. (128 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A182R366	A0A182R4Q9	A0A182R366	A0A182R4Q9	CPSF_A domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.999
A0A182R366	A0A182R6W2	A0A182R366	A0A182R6W2	CPSF_A domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.824
A0A182R366	A0A182R7S6	A0A182R366	A0A182R7S6	CPSF_A domain-containing protein.	Uncharacterized protein.	0.703
A0A182R366	A0A182RCM0	A0A182R366	A0A182RCM0	CPSF_A domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.996
A0A182R366	A0A182REB1	A0A182R366	A0A182REB1	CPSF_A domain-containing protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.902
A0A182R366	A0A182REB2	A0A182R366	A0A182REB2	CPSF_A domain-containing protein.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.780
A0A182R366	A0A182REM2	A0A182R366	A0A182REM2	CPSF_A domain-containing protein.	CBFD_NFYB_HMF domain-containing protein.	0.751
A0A182R366	A0A182RFI3	A0A182R366	A0A182RFI3	CPSF_A domain-containing protein.	40S ribosomal protein S27A.	0.799
A0A182R366	A0A182RJQ0	A0A182R366	A0A182RJQ0	CPSF_A domain-containing protein.	Uncharacterized protein.	0.769
A0A182R366	A0A182RM23	A0A182R366	A0A182RM23	CPSF_A domain-containing protein.	USP domain-containing protein; Belongs to the peptidase C19 family.	0.688
A0A182R366	A0A182RMA2	A0A182R366	A0A182RMA2	CPSF_A domain-containing protein.	RPA_C domain-containing protein.	0.784
A0A182R366	A0A182RPL3	A0A182R366	A0A182RPL3	CPSF_A domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.669
A0A182R366	A0A182RR05	A0A182R366	A0A182RR05	CPSF_A domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.691
A0A182R366	A0A182RSN2	A0A182R366	A0A182RSN2	CPSF_A domain-containing protein.	Protein kinase domain-containing protein.	0.798
A0A182R366	A0A182RTR4	A0A182R366	A0A182RTR4	CPSF_A domain-containing protein.	AAA domain-containing protein.	0.799
A0A182R366	A0A182RUX4	A0A182R366	A0A182RUX4	CPSF_A domain-containing protein.	CBFD_NFYB_HMF domain-containing protein.	0.787
A0A182R366	A0A182RVQ9	A0A182R366	A0A182RVQ9	CPSF_A domain-containing protein.	Replication factor C subunit 1.	0.790
A0A182R366	A0A182RWG0	A0A182R366	A0A182RWG0	CPSF_A domain-containing protein.	Rep_fac_C domain-containing protein.	0.811
A0A182R366	A0A182RX16	A0A182R366	A0A182RX16	CPSF_A domain-containing protein.	RING-type domain-containing protein.	0.996
A0A182R366	A0A182RXB5	A0A182R366	A0A182RXB5	CPSF_A domain-containing protein.	AAA domain-containing protein.	0.640