(32 nodes) G-protein mediated events network (Anopheles funestus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A4Y0BFN8	Uncharacterized protein. (378 aa)
	A0A4Y0BS96	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1153 aa)
	A0A4Y0BRF3	Uncharacterized protein. (384 aa)
	A0A4Y0BNZ6	Non-specific serine/threonine protein kinase. (544 aa)
	A0A4Y0BNQ0	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1214 aa)
	A0A4Y0BMQ3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1212 aa)
	A0A4Y0BM02	Phosphodiesterase. (702 aa)
	A0A4Y0BLW5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1429 aa)
	A0A4Y0BLS5	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (762 aa)
	A0A4Y0BKA1	Uncharacterized protein. (324 aa)
	A0A4Y0BK23	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1425 aa)
	A0A4Y0BJP4	Uncharacterized protein. (373 aa)
	A0A4Y0BJM5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1089 aa)
	A0A4Y0BJG9	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (666 aa)
	A0A4Y0BIT3	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (667 aa)
	A0A4Y0BID9	Non-specific serine/threonine protein kinase. (2153 aa)
	A0A4Y0BHT5	Uncharacterized protein. (321 aa)
	A0A4Y0BH93	Uncharacterized protein. (322 aa)
	A0A4Y0BH77	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1230 aa)
	A0A4Y0BER1	Protein kinase domain-containing protein. (258 aa)
	A0A4Y0BE73	Uncharacterized protein; Belongs to the protein kinase superfamily. (353 aa)
	A0A4Y0ASC2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1224 aa)
	A0A182RWE5	Uncharacterized protein. (614 aa)
	A0A182RBC5	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1216 aa)
	A0A182RA32	Uncharacterized protein. (396 aa)
	A0A182R6E7	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1663 aa)
	A0A182R3P4	LMWPc domain-containing protein. (161 aa)
	A0A182R3G0	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (2219 aa)
	A0A182R2B4	RGS domain-containing protein. (51 aa)
	A0A182R2B3	RGS domain-containing protein. (119 aa)
	A0A182R2B2	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (506 aa)
	A0A182R220	Uncharacterized protein. (3305 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A182R2B2	A0A182R2B3	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	RGS domain-containing protein.	0.923
A0A182R2B2	A0A182RA32	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	Uncharacterized protein.	0.500
A0A182R2B2	A0A4Y0BE73	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.726
A0A182R2B3	A0A182R2B2	RGS domain-containing protein.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.923
A0A182R2B3	A0A182RA32	RGS domain-containing protein.	Uncharacterized protein.	0.500
A0A182R2B3	A0A4Y0BE73	RGS domain-containing protein.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.771
A0A182R2B4	A0A182RA32	RGS domain-containing protein.	Uncharacterized protein.	0.465
A0A182R2B4	A0A4Y0BE73	RGS domain-containing protein.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.726
A0A182R3G0	A0A182R6E7	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.701
A0A182R3G0	A0A182RA32	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.417
A0A182R3G0	A0A182RBC5	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.596
A0A182R3G0	A0A4Y0ASC2	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.596
A0A182R3G0	A0A4Y0BE73	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.679
A0A182R3G0	A0A4Y0BFN8	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.461
A0A182R3G0	A0A4Y0BH93	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.461
A0A182R3G0	A0A4Y0BHT5	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.461
A0A182R3G0	A0A4Y0BIT3	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.426
A0A182R3G0	A0A4Y0BJG9	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.426
A0A182R3G0	A0A4Y0BJP4	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.461
A0A182R3G0	A0A4Y0BKA1	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.461