(81 nodes) EPH-Ephrin signaling network (Anopheles funestus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A182R7N8	Uncharacterized protein. (403 aa)
	A0A182RJF3	Uncharacterized protein. (700 aa)
	A0A182RJ38	Uncharacterized protein. (555 aa)
	A0A182RIZ2	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (304 aa)
	A0A182RIM5	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
	A0A182RHA3	Uncharacterized protein. (239 aa)
	A0A182RH15	Uncharacterized protein. (190 aa)
	A0A182RG91	Ephrin RBD domain-containing protein; Belongs to the ephrin family. (535 aa)
	A0A182RFR1	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (150 aa)
	A0A182RD42	Urb2 domain-containing protein. (1457 aa)
	A0A182RB14	Uncharacterized protein. (1347 aa)
	A0A182RA47	AP complex subunit beta. (946 aa)
	A0A182R8J8	Uncharacterized protein. (376 aa)
	A0A182R8J7	Uncharacterized protein. (376 aa)
	A0A182R8J6	Uncharacterized protein. (376 aa)
	A0A4Y0BMB8	Uncharacterized protein. (1145 aa)
	A0A4Y0BMD2	Uncharacterized protein. (964 aa)
	A0A4Y0BMR3	Uncharacterized protein. (1690 aa)
	A0A4Y0BN33	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (231 aa)
	A0A4Y0BPE8	Uncharacterized protein. (673 aa)
	A0A4Y0BPF5	Uncharacterized protein. (201 aa)
	A0A4Y0BPL7	Uncharacterized protein. (1735 aa)
	A0A4Y0BQQ2	Uncharacterized protein. (1921 aa)
	A0A4Y0BQX9	ZnMc domain-containing protein. (576 aa)
	A0A4Y0BRV6	Uncharacterized protein. (207 aa)
	A0A4Y0BTM6	Uncharacterized protein. (146 aa)
	A0A453YNS8	LITAF domain-containing protein. (82 aa)
	A0A2Y9D1W5	Uncharacterized protein. (2547 aa)
	A0A2Y9D1P9	Uncharacterized protein. (1287 aa)
	A0A1I8JUS5	Nicastrin. (719 aa)
	A0A1I8JUN7	Uncharacterized protein. (229 aa)
	A0A1I8JUL6	Uncharacterized protein. (251 aa)
	A0A182S529	Uncharacterized protein. (376 aa)
	A0A182S528	Uncharacterized protein. (376 aa)
	A0A182S4J5	Uncharacterized protein. (376 aa)
	A0A182RZM2	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
	A0A182RY71	Uncharacterized protein. (506 aa)
	A0A182RWF0	Uncharacterized protein. (1166 aa)
	A0A182RVV6	Uncharacterized protein. (1098 aa)
	A0A182RUN5	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (219 aa)
	A0A182RUM2	Protein kinase domain-containing protein. (532 aa)
	A0A182RTN0	Uncharacterized protein; Belongs to the actin family. (418 aa)
	A0A182RTL3	Uncharacterized protein. (376 aa)
	A0A182RT13	Uncharacterized protein. (948 aa)
	A0A182RST5	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (148 aa)
	A0A182RSJ6	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (374 aa)
	A0A182RR66	Tyrosine-protein kinase. (537 aa)
	A0A182RP69	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (438 aa)
	A0A182RNQ9	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (882 aa)
	A0A182RNQ5	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1673 aa)
	A0A182RNJ7	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
	A0A182RNB9	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (521 aa)
	A0A182RM36	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (395 aa)
	A0A182RLY0	WH2 domain-containing protein. (92 aa)
	A0A182RKX5	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1412 aa)
	A0A182RKQ1	Uncharacterized protein. (376 aa)
	A0A182RKH8	Uncharacterized protein; Belongs to the actin family. (229 aa)
	A0A182R5P4	Uncharacterized protein. (1113 aa)
	A0A182RJH8	ZnMc domain-containing protein. (547 aa)
	A0A182R7T1	FH2 domain-containing protein. (1626 aa)
	A0A4Y0BI89	Uncharacterized protein. (1194 aa)
	A0A4Y0BIK6	Uncharacterized protein. (1547 aa)
	A0A4Y0BJL5	Uncharacterized protein. (2330 aa)
	A0A4Y0BJV6	Uncharacterized protein. (1892 aa)
	A0A4Y0BK04	Uncharacterized protein. (1579 aa)
	A0A4Y0BKH0	Uncharacterized protein. (779 aa)
	A0A4Y0BLJ0	Uncharacterized protein. (1978 aa)
	A0A4Y0BLQ3	AP-2 complex subunit alpha; Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. (933 aa)
	A0A4Y0BLS3	Uncharacterized protein. (192 aa)
	A0A4Y0BLW1	ZnMc domain-containing protein. (317 aa)
	A0A4Y0BI77	ANF_receptor domain-containing protein. (451 aa)
	A0A4Y0BI06	ZnMc domain-containing protein. (476 aa)
	A0A4Y0BH18	Non-specific serine/threonine protein kinase. (686 aa)
	A0A4Y0BGP3	Uncharacterized protein. (1057 aa)
	A0A4Y0BGN2	Uncharacterized protein. (101 aa)
	A0A4Y0BFK9	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (640 aa)
	A0A4Y0BF95	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (227 aa)
	A0A4Y0B1N5	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (903 aa)
	A0A4Y0AVG3	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (321 aa)
	A0A4Y0ATI0	AP complex subunit beta. (930 aa)
	A0A4Y0ARZ1	Uncharacterized protein. (1457 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A182R7N8	A0A182R8J6	Uncharacterized protein.	Uncharacterized protein.	0.619
A0A182R7N8	A0A182R8J7	Uncharacterized protein.	Uncharacterized protein.	0.619
A0A182R7N8	A0A182R8J8	Uncharacterized protein.	Uncharacterized protein.	0.619
A0A182R7N8	A0A182RG91	Uncharacterized protein.	Ephrin RBD domain-containing protein; Belongs to the ephrin family.	0.899
A0A182R7N8	A0A182RH15	Uncharacterized protein.	Uncharacterized protein.	0.536
A0A182R7N8	A0A182RIZ2	Uncharacterized protein.	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.693
A0A182R7N8	A0A182RJ38	Uncharacterized protein.	Uncharacterized protein.	0.961
A0A182R7N8	A0A182RJF3	Uncharacterized protein.	Uncharacterized protein.	0.774
A0A182R7N8	A0A182RKH8	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.619
A0A182R7N8	A0A182RKQ1	Uncharacterized protein.	Uncharacterized protein.	0.619
A0A182R7N8	A0A182RKX5	Uncharacterized protein.	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.568
A0A182R7N8	A0A182RLY0	Uncharacterized protein.	WH2 domain-containing protein.	0.933
A0A182R7N8	A0A182RM36	Uncharacterized protein.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.802
A0A182R7N8	A0A182RNQ5	Uncharacterized protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.627
A0A182R7N8	A0A182RNQ9	Uncharacterized protein.	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.448
A0A182R7N8	A0A182RR66	Uncharacterized protein.	Tyrosine-protein kinase.	0.726
A0A182R7N8	A0A182RSJ6	Uncharacterized protein.	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.673
A0A182R7N8	A0A182RT13	Uncharacterized protein.	Uncharacterized protein.	0.491
A0A182R7N8	A0A182RTL3	Uncharacterized protein.	Uncharacterized protein.	0.619
A0A182R7N8	A0A182RTN0	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.685