(31 nodes) SUMOylation of DNA damage response and repair proteins network (Anopheles funestus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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Your Input:
	A0A4Y0B8M9	Uncharacterized protein. (1888 aa)
	A0A182R2N2	BRCT domain-containing protein. (1176 aa)
	A0A182R241	Small ubiquitin-related modifier. (93 aa)
	A0A182R1R0	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (325 aa)
	A0A182RPL3	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
	A0A182RQ96	Uncharacterized protein. (235 aa)
	A0A182RUV4	Uncharacterized protein. (668 aa)
	A0A182RYL2	Uncharacterized protein. (338 aa)
	A0A182RNA9	Uncharacterized protein. (1459 aa)
	A0A182RYQ9	Uncharacterized protein. (562 aa)
	A0A182RZM0	Uncharacterized protein. (2003 aa)
	A0A182S069	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (159 aa)
	A0A182R665	RING-type domain-containing protein. (428 aa)
	A0A4Y0BDZ6	BRCT domain-containing protein. (1176 aa)
	A0A4Y0BE15	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
	A0A4Y0BED8	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (277 aa)
	A0A4Y0BFN2	Uncharacterized protein. (86 aa)
	A0A4Y0BGI1	RING-type domain-containing protein. (1687 aa)
	A0A4Y0BI60	SAM domain-containing protein. (834 aa)
	A0A4Y0BIC3	RING-type domain-containing protein. (1488 aa)
	A0A4Y0BLA0	Rad60-SLD domain-containing protein. (82 aa)
	A0A4Y0BN17	SP-RING-type domain-containing protein. (201 aa)
	A0A4Y0BPI2	SMC_N domain-containing protein. (1088 aa)
	A0A182RJN7	Chromo domain-containing protein. (503 aa)
	A0A182RIX6	Poly [ADP-ribose] polymerase. (1001 aa)
	A0A182RIM3	Small ubiquitin-related modifier. (94 aa)
	A0A182RHV8	SAM domain-containing protein. (1032 aa)
	A0A182RHR0	AAA_23 domain-containing protein. (1038 aa)
	A0A182RF37	RING-type domain-containing protein. (712 aa)
	A0A182RF05	Uncharacterized protein. (1628 aa)
	A0A182RD75	SUMO-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. (159 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A182R1R0	A0A182R241	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.	Small ubiquitin-related modifier.	0.688
A0A182R1R0	A0A182R2N2	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.	BRCT domain-containing protein.	0.448
A0A182R1R0	A0A182RD75	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.	SUMO-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family.	0.590
A0A182R1R0	A0A182RHR0	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.	AAA_23 domain-containing protein.	0.989
A0A182R1R0	A0A182RIM3	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.	Small ubiquitin-related modifier.	0.688
A0A182R1R0	A0A182RQ96	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.	Uncharacterized protein.	0.987
A0A182R1R0	A0A182RZM0	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.	Uncharacterized protein.	0.448
A0A182R1R0	A0A182S069	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.590
A0A182R1R0	A0A4Y0BDZ6	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.	BRCT domain-containing protein.	0.448
A0A182R1R0	A0A4Y0BE15	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.590
A0A182R1R0	A0A4Y0BLA0	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.	Rad60-SLD domain-containing protein.	0.688
A0A182R1R0	A0A4Y0BN17	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.	SP-RING-type domain-containing protein.	0.985
A0A182R1R0	A0A4Y0BPI2	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.	SMC_N domain-containing protein.	0.987
A0A182R241	A0A182R1R0	Small ubiquitin-related modifier.	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.	0.688
A0A182R241	A0A182R2N2	Small ubiquitin-related modifier.	BRCT domain-containing protein.	0.747
A0A182R241	A0A182R665	Small ubiquitin-related modifier.	RING-type domain-containing protein.	0.552
A0A182R241	A0A182RD75	Small ubiquitin-related modifier.	SUMO-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family.	0.954
A0A182R241	A0A182RF05	Small ubiquitin-related modifier.	Uncharacterized protein.	0.851
A0A182R241	A0A182RF37	Small ubiquitin-related modifier.	RING-type domain-containing protein.	0.613
A0A182R241	A0A182RHR0	Small ubiquitin-related modifier.	AAA_23 domain-containing protein.	0.893