41 items (Anopheles funestus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A182R1W2	Uncharacterized protein. (1239 aa)
	A0A182R4V5	3'-5' exonuclease domain-containing protein. (810 aa)
	A0A182R5P0	P53 domain-containing protein. (399 aa)
	A0A182R703	DUF1767 domain-containing protein. (642 aa)
	A0A182R9J3	3'-5' exonuclease domain-containing protein. (313 aa)
	A0A182RCN4	Uncharacterized protein. (929 aa)
	A0A182RCW2	P53 domain-containing protein. (440 aa)
	A0A182REX6	Uncharacterized protein. (477 aa)
	A0A182RF05	Uncharacterized protein. (1628 aa)
	A0A182RF37	RING-type domain-containing protein. (712 aa)
	A0A182RFP9	14-3-3 zeta; Belongs to the 14-3-3 family. (248 aa)
	A0A182RFZ4	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (256 aa)
	A0A182RGB2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
	A0A182RHY4	Rhodanese domain-containing protein. (649 aa)
	A0A182RHY8	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (976 aa)
	A0A182RL37	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	A0A182RLK2	Uncharacterized protein. (358 aa)
	A0A182RPL3	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
	A0A182RSA0	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2649 aa)
	A0A182RSY5	Uncharacterized protein. (1571 aa)
	A0A182RU99	Wee1-like protein kinase. (645 aa)
	A0A182RUI3	Uncharacterized protein. (867 aa)
	A0A182RVJ2	Protein kinase domain-containing protein. (393 aa)
	A0A182RXT0	FHA domain-containing protein. (271 aa)
	A0A182S015	Reverse transcriptase domain-containing protein. (340 aa)
	A0A1D6TC74	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	A0A4Y0AV06	BRCT domain-containing protein. (1575 aa)
	A0A4Y0BCX6	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (482 aa)
	A0A4Y0BDQ7	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2661 aa)
	A0A4Y0BEB8	Uncharacterized protein. (1571 aa)
	A0A4Y0BEI8	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (680 aa)
	A0A4Y0BF97	Uncharacterized protein. (366 aa)
	A0A4Y0BGE7	Uncharacterized protein. (460 aa)
	A0A4Y0BHX0	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (482 aa)
	A0A4Y0BI68	Uncharacterized protein. (96 aa)
	A0A4Y0BJE3	Uncharacterized protein. (528 aa)
	A0A4Y0BL97	ANK_REP_REGION domain-containing protein. (1313 aa)
	A0A4Y0BNI3	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa)
	A0A4Y0BP53	Uncharacterized protein. (478 aa)
	A0A4Y0BQD3	Uncharacterized protein. (1159 aa)
	W6FTC9_ANOFN	14-3-3 zeta; Belongs to the 14-3-3 family. (248 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A182R1W2	A0A182R4V5	A0A182R1W2	A0A182R4V5	Uncharacterized protein.	3'-5' exonuclease domain-containing protein.	0.586
A0A182R1W2	A0A182R9J3	A0A182R1W2	A0A182R9J3	Uncharacterized protein.	3'-5' exonuclease domain-containing protein.	0.586
A0A182R1W2	A0A182RCW2	A0A182R1W2	A0A182RCW2	Uncharacterized protein.	P53 domain-containing protein.	0.527
A0A182R1W2	A0A182RF05	A0A182R1W2	A0A182RF05	Uncharacterized protein.	Uncharacterized protein.	0.929
A0A182R1W2	A0A182RHY8	A0A182R1W2	A0A182RHY8	Uncharacterized protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.997
A0A182R1W2	A0A182RPL3	A0A182R1W2	A0A182RPL3	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.930
A0A182R1W2	A0A182RSA0	A0A182R1W2	A0A182RSA0	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.652
A0A182R1W2	A0A182RSY5	A0A182R1W2	A0A182RSY5	Uncharacterized protein.	Uncharacterized protein.	0.650
A0A182R1W2	A0A182RUI3	A0A182R1W2	A0A182RUI3	Uncharacterized protein.	Uncharacterized protein.	0.586
A0A182R1W2	A0A182RVJ2	A0A182R1W2	A0A182RVJ2	Uncharacterized protein.	Protein kinase domain-containing protein.	0.637
A0A182R1W2	A0A4Y0BDQ7	A0A182R1W2	A0A4Y0BDQ7	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.652
A0A182R1W2	A0A4Y0BEB8	A0A182R1W2	A0A4Y0BEB8	Uncharacterized protein.	Uncharacterized protein.	0.650
A0A182R1W2	A0A4Y0BEI8	A0A182R1W2	A0A4Y0BEI8	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.948
A0A182R1W2	A0A4Y0BI68	A0A182R1W2	A0A4Y0BI68	Uncharacterized protein.	Uncharacterized protein.	0.591
A0A182R1W2	A0A4Y0BJE3	A0A182R1W2	A0A4Y0BJE3	Uncharacterized protein.	Uncharacterized protein.	0.591
A0A182R1W2	A0A4Y0BNI3	A0A182R1W2	A0A4Y0BNI3	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.948
A0A182R1W2	A0A4Y0BP53	A0A182R1W2	A0A4Y0BP53	Uncharacterized protein.	Uncharacterized protein.	0.630
A0A182R4V5	A0A182R1W2	A0A182R4V5	A0A182R1W2	3'-5' exonuclease domain-containing protein.	Uncharacterized protein.	0.586
A0A182R4V5	A0A182R703	A0A182R4V5	A0A182R703	3'-5' exonuclease domain-containing protein.	DUF1767 domain-containing protein.	0.586
A0A182R4V5	A0A182RCW2	A0A182R4V5	A0A182RCW2	3'-5' exonuclease domain-containing protein.	P53 domain-containing protein.	0.624