(50 nodes) Ubiquitin Mediated Degradation of Phosphorylated Cdc25A network (Anopheles funestus)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	A0A182R1X9	MPN domain-containing protein. (338 aa)
	A0A182R3V0	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (900 aa)
	A0A182R4A9	Proteasome subunit beta. (205 aa)
	A0A182R513	Uncharacterized protein. (486 aa)
	A0A182R676	PCI domain-containing protein. (389 aa)
	A0A182R7E5	PI31_Prot_N domain-containing protein. (250 aa)
	A0A182R7H2	Nas2_N domain-containing protein. (204 aa)
	A0A182R9S0	PCI domain-containing protein. (497 aa)
	A0A182RAC6	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (276 aa)
	A0A182RC23	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (249 aa)
	A0A182RE57	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (260 aa)
	A0A182REX6	Uncharacterized protein. (477 aa)
	A0A182RFD2	Proteasome subunit beta. (279 aa)
	A0A182RFI3	40S ribosomal protein S27A. (156 aa)
	A0A182RHY4	Rhodanese domain-containing protein. (649 aa)
	A0A182RIL9	Proteasome subunit beta. (205 aa)
	A0A182RIN6	Proteasome subunit beta. (228 aa)
	A0A182RJQ0	Uncharacterized protein. (206 aa)
	A0A182RK71	MPN domain-containing protein. (311 aa)
	A0A182RLE0	PCI domain-containing protein. (262 aa)
	A0A182RLE9	Uncharacterized protein. (1921 aa)
	A0A182RM64	Uncharacterized protein. (260 aa)
	A0A182RMH0	VWFA domain-containing protein. (411 aa)
	A0A182RN14	PCI domain-containing protein. (460 aa)
	A0A182RNG2	AAA domain-containing protein; Belongs to the AAA ATPase family. (392 aa)
	A0A182RNR9	AAA domain-containing protein; Belongs to the AAA ATPase family. (412 aa)
	A0A182RPD3	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (1037 aa)
	A0A182RPF7	AAA domain-containing protein; Belongs to the AAA ATPase family. (428 aa)
	A0A182RPU2	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (234 aa)
	A0A182RPW6	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (253 aa)
	A0A182RTE5	AAA domain-containing protein; Belongs to the AAA ATPase family. (434 aa)
	A0A182RVJ2	Protein kinase domain-containing protein. (393 aa)
	A0A182RW77	Proteasome subunit beta. (284 aa)
	A0A182RW83	MPN domain-containing protein. (177 aa)
	A0A182RX91	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (242 aa)
	A0A182RY12	AAA domain-containing protein; Belongs to the AAA ATPase family. (432 aa)
	A0A182RY65	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (246 aa)
	A0A1Y9HDY5	Proteasome 26S non-ATPase subunit. (416 aa)
	A0A4Y0BF84	Uncharacterized protein. (609 aa)
	A0A4Y0BG84	PCI domain-containing protein. (416 aa)
	A0A4Y0BGR5	Uncharacterized protein. (913 aa)
	A0A4Y0BGY7	AAA domain-containing protein; Belongs to the AAA ATPase family. (438 aa)
	A0A4Y0BI70	KxDL domain-containing protein. (254 aa)
	A0A4Y0BKB4	Uncharacterized protein. (533 aa)
	A0A4Y0BKQ4	KxDL domain-containing protein. (254 aa)
	A0A4Y0BLD9	Uncharacterized protein. (264 aa)
	A0A4Y0BQ44	Proteasome subunit beta; Belongs to the peptidase T1B family. (272 aa)
	A0A4Y0BRV9	PCI domain-containing protein. (380 aa)
	A0A4Y0BSS2	AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
	Q06DG5_ANOFN	60S ribosomal protein L40. (128 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A182R1X9	A0A182R3V0	A0A182R1X9	A0A182R3V0	MPN domain-containing protein.	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.	0.994
A0A182R1X9	A0A182R4A9	A0A182R1X9	A0A182R4A9	MPN domain-containing protein.	Proteasome subunit beta.	0.988
A0A182R1X9	A0A182R513	A0A182R1X9	A0A182R513	MPN domain-containing protein.	Uncharacterized protein.	0.972
A0A182R1X9	A0A182R676	A0A182R1X9	A0A182R676	MPN domain-containing protein.	PCI domain-containing protein.	0.995
A0A182R1X9	A0A182R7E5	A0A182R1X9	A0A182R7E5	MPN domain-containing protein.	PI31_Prot_N domain-containing protein.	0.555
A0A182R1X9	A0A182R7H2	A0A182R1X9	A0A182R7H2	MPN domain-containing protein.	Nas2_N domain-containing protein.	0.850
A0A182R1X9	A0A182R9S0	A0A182R1X9	A0A182R9S0	MPN domain-containing protein.	PCI domain-containing protein.	0.994
A0A182R1X9	A0A182RAC6	A0A182R1X9	A0A182RAC6	MPN domain-containing protein.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.987
A0A182R1X9	A0A182RC23	A0A182R1X9	A0A182RC23	MPN domain-containing protein.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.993
A0A182R1X9	A0A182RE57	A0A182R1X9	A0A182RE57	MPN domain-containing protein.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.993
A0A182R1X9	A0A182REX6	A0A182R1X9	A0A182REX6	MPN domain-containing protein.	Uncharacterized protein.	0.543
A0A182R1X9	A0A182RFD2	A0A182R1X9	A0A182RFD2	MPN domain-containing protein.	Proteasome subunit beta.	0.985
A0A182R1X9	A0A182RFI3	A0A182R1X9	A0A182RFI3	MPN domain-containing protein.	40S ribosomal protein S27A.	0.939
A0A182R1X9	A0A182RIL9	A0A182R1X9	A0A182RIL9	MPN domain-containing protein.	Proteasome subunit beta.	0.988
A0A182R1X9	A0A182RIN6	A0A182R1X9	A0A182RIN6	MPN domain-containing protein.	Proteasome subunit beta.	0.985
A0A182R1X9	A0A182RJQ0	A0A182R1X9	A0A182RJQ0	MPN domain-containing protein.	Uncharacterized protein.	0.920
A0A182R1X9	A0A182RK71	A0A182R1X9	A0A182RK71	MPN domain-containing protein.	MPN domain-containing protein.	0.996
A0A182R1X9	A0A182RLE0	A0A182R1X9	A0A182RLE0	MPN domain-containing protein.	PCI domain-containing protein.	0.995
A0A182R1X9	A0A182RLE9	A0A182R1X9	A0A182RLE9	MPN domain-containing protein.	Uncharacterized protein.	0.769
A0A182R1X9	A0A182RM64	A0A182R1X9	A0A182RM64	MPN domain-containing protein.	Uncharacterized protein.	0.838