(42 nodes) Chromosome Maintenance network (Anopheles funestus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A4Y0BH04	Serine/threonine-protein phosphatase. (304 aa)
	A0A4Y0BFP6	SHQ1 domain-containing protein. (367 aa)
	A0A4Y0BEX5	ATP-dependent DNA helicase; Belongs to the helicase family. (1078 aa)
	A0A4Y0BEE5	AAA domain-containing protein. (348 aa)
	A0A1D6TC74	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	A0A182S4T2	Daxx-like protein. (605 aa)
	A0A182RXB5	AAA domain-containing protein. (360 aa)
	A0A182RWG0	Rep_fac_C domain-containing protein. (358 aa)
	A0A182RV72	Uncharacterized protein. (2087 aa)
	A0A182RNI1	Uncharacterized protein. (2485 aa)
	A0A182RLT7	Uncharacterized protein. (664 aa)
	A0A182RLT3	Uncharacterized protein. (419 aa)
	A0A182RL37	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	A0A182RI42	Uncharacterized protein. (134 aa)
	A0A182RI40	Nucleoplasmin domain-containing protein. (175 aa)
	A0A182RHY8	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (976 aa)
	A0A182RGY1	Uncharacterized protein. (1494 aa)
	A0A182RGT1	TM2 domain-containing protein. (254 aa)
	A0A182RF05	Uncharacterized protein. (1628 aa)
	A0A182RDN7	Uncharacterized protein. (465 aa)
	A0A182RCV0	Helitron_like_N domain-containing protein. (206 aa)
	A0A182RAT7	Uncharacterized protein. (2933 aa)
	A0A182R9J3	3'-5' exonuclease domain-containing protein. (313 aa)
	A0A182R8R7	SHQ1 domain-containing protein. (421 aa)
	A0A182R4X4	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (241 aa)
	A0A182R4V5	3'-5' exonuclease domain-containing protein. (810 aa)
	A0A182R3T5	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. (472 aa)
	A0A182R2S0	PUA domain-containing protein. (520 aa)
	A0A182R1I2	WD_REPEATS_REGION domain-containing protein. (433 aa)
	A0A182RUR9	AAA domain-containing protein. (1004 aa)
	A0A182RUI3	Uncharacterized protein. (867 aa)
	PIF1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (672 aa)
	A0A182RTR4	AAA domain-containing protein. (327 aa)
	A0A182RSN2	Protein kinase domain-containing protein. (582 aa)
	A0A182RR13	PHD-type domain-containing protein. (1675 aa)
	A0A182RQV5	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (156 aa)
	A0A182RPL3	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
	A0A4Y0BRE3	Uncharacterized protein. (64 aa)
	A0A4Y0BPN2	Uncharacterized protein. (1026 aa)
	A0A4Y0BPA0	Uncharacterized protein. (1025 aa)
	A0A4Y0BMX6	Uncharacterized protein. (167 aa)
	A0A4Y0BJ30	Helitron_like_N domain-containing protein. (560 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A182R1I2	A0A182R2S0	A0A182R1I2	A0A182R2S0	WD_REPEATS_REGION domain-containing protein.	PUA domain-containing protein.	0.993
A0A182R1I2	A0A182R3T5	A0A182R1I2	A0A182R3T5	WD_REPEATS_REGION domain-containing protein.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.	0.589
A0A182R1I2	A0A182R4X4	A0A182R1I2	A0A182R4X4	WD_REPEATS_REGION domain-containing protein.	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.	0.990
A0A182R1I2	A0A182RQV5	A0A182R1I2	A0A182RQV5	WD_REPEATS_REGION domain-containing protein.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.986
A0A182R1I2	A0A4Y0BRE3	A0A182R1I2	A0A4Y0BRE3	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.976
A0A182R2S0	A0A182R1I2	A0A182R2S0	A0A182R1I2	PUA domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.993
A0A182R2S0	A0A182R3T5	A0A182R2S0	A0A182R3T5	PUA domain-containing protein.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.	0.963
A0A182R2S0	A0A182R4X4	A0A182R2S0	A0A182R4X4	PUA domain-containing protein.	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.	0.999
A0A182R2S0	A0A182R8R7	A0A182R2S0	A0A182R8R7	PUA domain-containing protein.	SHQ1 domain-containing protein.	0.981
A0A182R2S0	A0A182RCV0	A0A182R2S0	A0A182RCV0	PUA domain-containing protein.	Helitron_like_N domain-containing protein.	0.550
A0A182R2S0	A0A182RHY8	A0A182R2S0	A0A182RHY8	PUA domain-containing protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.443
A0A182R2S0	A0A182RI40	A0A182R2S0	A0A182RI40	PUA domain-containing protein.	Nucleoplasmin domain-containing protein.	0.410
A0A182R2S0	A0A182RQV5	A0A182R2S0	A0A182RQV5	PUA domain-containing protein.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.999
A0A182R2S0	A0A4Y0BEX5	A0A182R2S0	A0A4Y0BEX5	PUA domain-containing protein.	ATP-dependent DNA helicase; Belongs to the helicase family.	0.550
A0A182R2S0	A0A4Y0BFP6	A0A182R2S0	A0A4Y0BFP6	PUA domain-containing protein.	SHQ1 domain-containing protein.	0.981
A0A182R2S0	A0A4Y0BH04	A0A182R2S0	A0A4Y0BH04	PUA domain-containing protein.	Serine/threonine-protein phosphatase.	0.543
A0A182R2S0	A0A4Y0BJ30	A0A182R2S0	A0A4Y0BJ30	PUA domain-containing protein.	Helitron_like_N domain-containing protein.	0.550
A0A182R2S0	A0A4Y0BRE3	A0A182R2S0	A0A4Y0BRE3	PUA domain-containing protein.	Uncharacterized protein.	0.999
A0A182R2S0	PIF1	A0A182R2S0	A0A182RU74	PUA domain-containing protein.	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	0.644
A0A182R3T5	A0A182R1I2	A0A182R3T5	A0A182R1I2	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.	WD_REPEATS_REGION domain-containing protein.	0.589