(64 nodes) Estrogen-dependent gene expression network (Anopheles funestus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A182R1Q6	Uncharacterized protein. (210 aa)
	A0A182R2E6	CYCLIN domain-containing protein; Belongs to the cyclin family. (1482 aa)
	A0A182R2L3	Uncharacterized protein; Belongs to the DEAD box helicase family. (648 aa)
	A0A182R2X3	Uncharacterized protein. (322 aa)
	A0A182R3F6	DUF2236 domain-containing protein. (350 aa)
	A0A182R4E6	Uncharacterized protein. (531 aa)
	A0A182R4W4	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (457 aa)
	A0A182R5K0	BZIP domain-containing protein. (318 aa)
	A0A182R846	Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (369 aa)
	A0A182RAG5	Uncharacterized protein. (299 aa)
	A0A182RAT5	Peptidylprolyl isomerase. (450 aa)
	A0A182RBA2	Uncharacterized protein; Belongs to the DEAD box helicase family. (574 aa)
	A0A182RC56	BHLH domain-containing protein. (232 aa)
	A0A182RCF2	Uncharacterized protein. (546 aa)
	A0A182RD05	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
	A0A182RDS4	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (127 aa)
	A0A182RFR5	Uncharacterized protein; Belongs to the DEAD box helicase family. (699 aa)
	A0A182RG64	RNA_pol_L_2 domain-containing protein. (117 aa)
	A0A182RGJ1	Mediator of RNA polymerase II transcription subunit 1. (2147 aa)
	A0A182RGR5	BHLH domain-containing protein. (1918 aa)
	A0A182RH66	Uncharacterized protein. (190 aa)
	A0A182RI55	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (112 aa)
	A0A182RJM8	HATPase_c domain-containing protein. (713 aa)
	A0A182RL37	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	A0A182RNB8	Uncharacterized protein. (480 aa)
	A0A182RPE5	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (570 aa)
	A0A182RPP5	Receptor protein-tyrosine kinase. (1465 aa)
	A0A182RSC9	RPOL4c domain-containing protein. (139 aa)
	A0A182RSS5	Uncharacterized protein. (908 aa)
	A0A182RSX9	Uncharacterized protein. (517 aa)
	A0A182RTD0	CS domain-containing protein. (172 aa)
	A0A182RVM6	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1877 aa)
	A0A182RVW3	Runt. (604 aa)
	A0A182RVZ4	Uncharacterized protein. (131 aa)
	A0A182RWC7	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (397 aa)
	A0A182RWZ6	RPOLD domain-containing protein. (273 aa)
	A0A182RY78	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (621 aa)
	A0A182RYR8	Uncharacterized protein. (821 aa)
	A0A182S4U1	Uncharacterized protein. (229 aa)
	A0A1D6TC74	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	A0A1Y9HC69	Uncharacterized protein. (507 aa)
	A0A4Y0ASA8	Uncharacterized protein; Belongs to the DEAD box helicase family. (707 aa)
	A0A4Y0ASW2	BHLH domain-containing protein. (251 aa)
	A0A4Y0AWQ2	BHLH domain-containing protein. (1820 aa)
	A0A4Y0B206	Receptor protein-tyrosine kinase. (1488 aa)
	A0A4Y0BD59	Uncharacterized protein. (59 aa)
	A0A4Y0BF93	HATPase_c domain-containing protein. (713 aa)
	A0A4Y0BGH3	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (191 aa)
	A0A4Y0BH90	Runt domain-containing protein. (765 aa)
	A0A4Y0BIA8	Uncharacterized protein. (230 aa)
	A0A4Y0BIM6	Uncharacterized protein. (545 aa)
	A0A4Y0BIQ7	Uncharacterized protein. (459 aa)
	A0A4Y0BJ92	Fork-head domain-containing protein. (472 aa)
	A0A4Y0BKD1	Uncharacterized protein. (4114 aa)
	A0A4Y0BKS9	Bromo domain-containing protein. (192 aa)
	A0A4Y0BLW2	Uncharacterized protein. (487 aa)
	A0A4Y0BLZ9	HATPase_c domain-containing protein. (713 aa)
	A0A4Y0BMI1	Uncharacterized protein. (173 aa)
	A0A4Y0BMT3	Uncharacterized protein. (868 aa)
	A0A4Y0BPZ6	Uncharacterized protein. (454 aa)
	A0A4Y0BQC3	Uncharacterized protein. (761 aa)
	A0A4Y0BR29	Runt domain-containing protein. (683 aa)
	A0A4Y0BUC9	Uncharacterized protein; Belongs to the DEAD box helicase family. (723 aa)
	A0A4Y0BUG1	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1175 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A182R1Q6	A0A182R2L3	Uncharacterized protein.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.689
A0A182R1Q6	A0A182R2X3	Uncharacterized protein.	Uncharacterized protein.	0.971
A0A182R1Q6	A0A182R3F6	Uncharacterized protein.	DUF2236 domain-containing protein.	0.984
A0A182R1Q6	A0A182R4E6	Uncharacterized protein.	Uncharacterized protein.	0.947
A0A182R1Q6	A0A182RBA2	Uncharacterized protein.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.689
A0A182R1Q6	A0A182RCF2	Uncharacterized protein.	Uncharacterized protein.	0.947
A0A182R1Q6	A0A182RD05	Uncharacterized protein.	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.	0.999
A0A182R1Q6	A0A182RDS4	Uncharacterized protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.	0.999
A0A182R1Q6	A0A182RFR5	Uncharacterized protein.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.689
A0A182R1Q6	A0A182RG64	Uncharacterized protein.	RNA_pol_L_2 domain-containing protein.	0.999
A0A182R1Q6	A0A182RGJ1	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 1.	0.984
A0A182R1Q6	A0A182RI55	Uncharacterized protein.	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family.	0.988
A0A182R1Q6	A0A182RL37	Uncharacterized protein.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.942
A0A182R1Q6	A0A182RNB8	Uncharacterized protein.	Uncharacterized protein.	0.986
A0A182R1Q6	A0A182RPE5	Uncharacterized protein.	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	0.997
A0A182R1Q6	A0A182RSS5	Uncharacterized protein.	Uncharacterized protein.	0.689
A0A182R1Q6	A0A182RSX9	Uncharacterized protein.	Uncharacterized protein.	0.477
A0A182R1Q6	A0A182RVM6	Uncharacterized protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.980
A0A182R1Q6	A0A182RVZ4	Uncharacterized protein.	Uncharacterized protein.	0.999
A0A182R1Q6	A0A182RWZ6	Uncharacterized protein.	RPOLD domain-containing protein.	0.999