(29 nodes) Ubiquinone and other terpenoid-quinone biosynthesis network (Anopheles funestus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	coq5	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (295 aa)
	A0A182RIZ8	Uncharacterized protein. (539 aa)
	A0A182RKC9	Uncharacterized protein. (561 aa)
	A0A182RM44	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (447 aa)
	A0A182R3I1	4HBT domain-containing protein. (143 aa)
	A0A182R329	Uncharacterized protein. (559 aa)
	coq7	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (191 aa)
	coq3	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (295 aa)
	A0A1I8JUE9	Uncharacterized protein. (538 aa)
	A0A1I8JUG9	Uncharacterized protein. (538 aa)
	A0A1I8JUI2	Oxysterol-binding protein. (545 aa)
	A0A1I8JUM6	Vitamin K-dependent gamma-carboxylase. (700 aa)
	A0A1I8JUU0	AMP dependent ligase. (542 aa)
	A0A1I8JUU2	Uncharacterized protein. (553 aa)
	A0A453YNN8	Uncharacterized protein. (1022 aa)
	A0A182R455	Uncharacterized protein. (600 aa)
	A0A453YNP7	AMP-binding domain-containing protein. (326 aa)
	A0A4Y0BL24	AB hydrolase-1 domain-containing protein. (305 aa)
	A0A4Y0BM60	4-hydroxyphenylpyruvate dioxygenase. (381 aa)
	A0A4Y0BM72	Uncharacterized protein. (582 aa)
	coq6	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (474 aa)
	A0A4Y0BQ78	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (237 aa)
	A0A182R867	Uncharacterized protein. (545 aa)
	A0A182RBI5	VKc domain-containing protein. (176 aa)
	A0A182RBP9	Uncharacterized protein. (341 aa)
	A0A182RCH1	Uncharacterized protein. (564 aa)
	coq2	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (437 aa)
	A0A182RE74	Uncharacterized protein. (532 aa)
	A0A182RHI1	SAP domain-containing protein. (1336 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A182R329	A0A182R455	A0A182R329	A0A182R455	Uncharacterized protein.	Uncharacterized protein.	0.564
A0A182R329	A0A182RKC9	A0A182R329	A0A182RKC9	Uncharacterized protein.	Uncharacterized protein.	0.451
A0A182R329	A0A1I8JUU0	A0A182R329	A0A1I8JUU0	Uncharacterized protein.	AMP dependent ligase.	0.452
A0A182R329	A0A1I8JUU2	A0A182R329	A0A1I8JUU2	Uncharacterized protein.	Uncharacterized protein.	0.462
A0A182R329	A0A4Y0BL24	A0A182R329	A0A4Y0BL24	Uncharacterized protein.	AB hydrolase-1 domain-containing protein.	0.466
A0A182R329	A0A4Y0BM72	A0A182R329	A0A4Y0BM72	Uncharacterized protein.	Uncharacterized protein.	0.465
A0A182R329	coq6	A0A182R329	A0A4Y0BNU4	Uncharacterized protein.	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	0.463
A0A182R3I1	A0A182RBP9	A0A182R3I1	A0A182RBP9	4HBT domain-containing protein.	Uncharacterized protein.	0.931
A0A182R455	A0A182R329	A0A182R455	A0A182R329	Uncharacterized protein.	Uncharacterized protein.	0.564
A0A182R455	A0A182R867	A0A182R455	A0A182R867	Uncharacterized protein.	Uncharacterized protein.	0.461
A0A182R455	A0A182RE74	A0A182R455	A0A182RE74	Uncharacterized protein.	Uncharacterized protein.	0.561
A0A182R455	A0A182RKC9	A0A182R455	A0A182RKC9	Uncharacterized protein.	Uncharacterized protein.	0.533
A0A182R455	A0A1I8JUE9	A0A182R455	A0A1I8JUE9	Uncharacterized protein.	Uncharacterized protein.	0.459
A0A182R455	A0A1I8JUG9	A0A182R455	A0A1I8JUG9	Uncharacterized protein.	Uncharacterized protein.	0.565
A0A182R455	A0A1I8JUI2	A0A182R455	A0A1I8JUI2	Uncharacterized protein.	Oxysterol-binding protein.	0.559
A0A182R455	A0A1I8JUU0	A0A182R455	A0A1I8JUU0	Uncharacterized protein.	AMP dependent ligase.	0.539
A0A182R455	A0A1I8JUU2	A0A182R455	A0A1I8JUU2	Uncharacterized protein.	Uncharacterized protein.	0.543
A0A182R455	A0A4Y0BL24	A0A182R455	A0A4Y0BL24	Uncharacterized protein.	AB hydrolase-1 domain-containing protein.	0.466
A0A182R455	coq6	A0A182R455	A0A4Y0BNU4	Uncharacterized protein.	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	0.463
A0A182R867	A0A182R455	A0A182R867	A0A182R455	Uncharacterized protein.	Uncharacterized protein.	0.461