(49 nodes) Valine, leucine and isoleucine degradation network (Anopheles funestus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A182RGX2	Aldedh domain-containing protein. (521 aa)
	A0A182RFA8	Uncharacterized protein. (419 aa)
	A0A182REX5	Uncharacterized protein. (416 aa)
	A0A182RD11	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (510 aa)
	A0A182RBH9	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (469 aa)
	A0A182R9B6	Uncharacterized protein. (428 aa)
	A0A182R810	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (255 aa)
	A0A182R6W9	Uncharacterized protein. (688 aa)
	A0A182R6J8	Uncharacterized protein. (720 aa)
	A0A182R3X9	Uncharacterized protein. (976 aa)
	A0A4Y0BWK2	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (318 aa)
	A0A4Y0BQW0	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (472 aa)
	A0A4Y0BPD2	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (389 aa)
	A0A4Y0BNE2	Uncharacterized protein. (307 aa)
	A0A4Y0BMX4	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (489 aa)
	A0A4Y0BME5	Uncharacterized protein. (617 aa)
	A0A4Y0BKX5	Uncharacterized protein. (293 aa)
	A0A4Y0BKR2	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (523 aa)
	A0A4Y0BKD0	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (254 aa)
	A0A4Y0BK78	Pyruvate carboxyltransferase domain-containing protein. (324 aa)
	A0A4Y0BK77	Uncharacterized protein. (589 aa)
	A0A4Y0BGW2	Aldedh domain-containing protein. (217 aa)
	A0A4Y0BGU2	Rubis-subs-bind domain-containing protein. (257 aa)
	A0A4Y0BGB5	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (299 aa)
	A0A4Y0BG61	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (330 aa)
	A0A4Y0BE65	Uncharacterized protein. (293 aa)
	A0A4Y0BDX8	Uncharacterized protein. (307 aa)
	A0A4Y0ATL2	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (512 aa)
	A0A1Y9HDW1	4-aminobutyrate aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (497 aa)
	A0A1I8JUT3	Aldehyde dehydrogenase family 7 member A1; Belongs to the aldehyde dehydrogenase family. (540 aa)
	A0A1I8JUQ7	SET domain-containing protein. (449 aa)
	A0A182RZM4	Uncharacterized protein. (322 aa)
	A0A182RZ09	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (469 aa)
	A0A182RYX9	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (299 aa)
	A0A182RYC7	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (443 aa)
	A0A182RXK0	Uncharacterized protein. (407 aa)
	A0A182RUZ0	Importin N-terminal domain-containing protein. (904 aa)
	A0A182RUF2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
	A0A182RU85	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (771 aa)
	A0A182RSY4	Uncharacterized protein. (589 aa)
	A0A182RRC7	PWWP domain-containing protein. (564 aa)
	A0A182RQP2	Dihydrolipoyl dehydrogenase. (506 aa)
	A0A182RNK6	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
	A0A182RNF4	Transket_pyr domain-containing protein. (365 aa)
	A0A182RMI7	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (331 aa)
	A0A182RLJ8	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (414 aa)
	A0A182RKM8	TPR_REGION domain-containing protein. (262 aa)
	A0A182RK82	Uncharacterized protein. (404 aa)
	A0A182RHV1	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (443 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A182R3X9	A0A182R6W9	Uncharacterized protein.	Uncharacterized protein.	0.491
A0A182R3X9	A0A182RBH9	Uncharacterized protein.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.608
A0A182R3X9	A0A182RD11	Uncharacterized protein.	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.661
A0A182R3X9	A0A182REX5	Uncharacterized protein.	Uncharacterized protein.	0.450
A0A182R3X9	A0A182RGX2	Uncharacterized protein.	Aldedh domain-containing protein.	0.647
A0A182R3X9	A0A182RHV1	Uncharacterized protein.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.700
A0A182R3X9	A0A182RK82	Uncharacterized protein.	Uncharacterized protein.	0.450
A0A182R3X9	A0A182RKM8	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.647
A0A182R3X9	A0A182RMI7	Uncharacterized protein.	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	0.497
A0A182R3X9	A0A182RNF4	Uncharacterized protein.	Transket_pyr domain-containing protein.	0.478
A0A182R3X9	A0A182RQP2	Uncharacterized protein.	Dihydrolipoyl dehydrogenase.	0.473
A0A182R3X9	A0A182RRC7	Uncharacterized protein.	PWWP domain-containing protein.	0.497
A0A182R3X9	A0A182RSY4	Uncharacterized protein.	Uncharacterized protein.	0.485
A0A182R3X9	A0A182RU85	Uncharacterized protein.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.531
A0A182R3X9	A0A182RXK0	Uncharacterized protein.	Uncharacterized protein.	0.450
A0A182R3X9	A0A182RYC7	Uncharacterized protein.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.518
A0A182R3X9	A0A182RYX9	Uncharacterized protein.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.508
A0A182R3X9	A0A182RZM4	Uncharacterized protein.	Uncharacterized protein.	0.508
A0A182R3X9	A0A1I8JUT3	Uncharacterized protein.	Aldehyde dehydrogenase family 7 member A1; Belongs to the aldehyde dehydrogenase family.	0.746
A0A182R3X9	A0A4Y0ATL2	Uncharacterized protein.	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.661