(38 nodes) Tryptophan metabolism network (Anopheles funestus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A4Y0BHF5	Uncharacterized protein. (282 aa)
	A0A4Y0BGW2	Aldedh domain-containing protein. (217 aa)
	A0A4Y0BGB5	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (299 aa)
	A0A4Y0BE65	Uncharacterized protein. (293 aa)
	A0A4Y0BDX8	Uncharacterized protein. (307 aa)
	A0A4Y0B4X2	Aminotran_1_2 domain-containing protein. (423 aa)
	A0A4Y0APB6	Dopamine N-acetyltransferase. (237 aa)
	A0A1I8JUT3	Aldehyde dehydrogenase family 7 member A1; Belongs to the aldehyde dehydrogenase family. (540 aa)
	A0A1I8JUK1	Glutaryl-CoA dehydrogenase. (428 aa)
	A0A182RZP9	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (485 aa)
	A0A182R7P4	Dopamine N-acetyltransferase. (282 aa)
	A0A182R9C4	N-acetyltransferase domain-containing protein. (222 aa)
	A0A182RBH6	Transket_pyr domain-containing protein. (917 aa)
	A0A182RBK3	Lipoyl-binding domain-containing protein. (493 aa)
	A0A182RDB0	Uncharacterized protein. (462 aa)
	A0A182RFS2	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (504 aa)
	A0A182RG95	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Required for elimination of toxic metabolites. (380 aa)
	A0A182RKW9	Tr-type G domain-containing protein. (722 aa)
	A0A182RLJ8	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (414 aa)
	A0A182RLK7	Amine oxidase. (531 aa)
	A0A182RMN7	N-acetyltransferase domain-containing protein. (202 aa)
	A0A182RNK6	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
	A0A182RPF4	Uncharacterized protein. (506 aa)
	A0A182RQP2	Dihydrolipoyl dehydrogenase. (506 aa)
	A0A182RSA7	Aminotran_1_2 domain-containing protein. (426 aa)
	A0A182RTD1	Aminotran_1_2 domain-containing protein. (450 aa)
	A0A182RU68	AAA domain-containing protein; Belongs to the AAA ATPase family. (622 aa)
	A0A182RU85	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (771 aa)
	A0A182RXK7	Diphthami_syn_2 domain-containing protein. (845 aa)
	A0A182RZM4	Uncharacterized protein. (322 aa)
	A0A182RYX9	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (299 aa)
	A0A182R450	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (393 aa)
	A0A4Y0BSF2	Spastin; ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the microtubule organizing center following nucleation; Belongs to the AAA ATPase family. Spastin subfamily. (906 aa)
	A0A4Y0BNE2	Uncharacterized protein. (307 aa)
	A0A4Y0BMX4	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (489 aa)
	A0A4Y0BME5	Uncharacterized protein. (617 aa)
	A0A4Y0BKX5	Uncharacterized protein. (293 aa)
	A0A4Y0BI05	Uncharacterized protein. (527 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A182R450	A0A182RG95	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Required for elimination of toxic metabolites.	0.966
A0A182R450	A0A182RLK7	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	Amine oxidase.	0.714
A0A182R450	A0A182RPF4	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	Uncharacterized protein.	0.933
A0A182R450	A0A182RTD1	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	Aminotran_1_2 domain-containing protein.	0.850
A0A182R450	A0A182RZP9	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.791
A0A182R450	A0A4Y0BI05	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	Uncharacterized protein.	0.933
A0A182RBH6	A0A182RBK3	Transket_pyr domain-containing protein.	Lipoyl-binding domain-containing protein.	0.998
A0A182RBH6	A0A182RLK7	Transket_pyr domain-containing protein.	Amine oxidase.	0.493
A0A182RBH6	A0A182RQP2	Transket_pyr domain-containing protein.	Dihydrolipoyl dehydrogenase.	0.990
A0A182RBH6	A0A182RSA7	Transket_pyr domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.643
A0A182RBH6	A0A182RTD1	Transket_pyr domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.527
A0A182RBH6	A0A1I8JUK1	Transket_pyr domain-containing protein.	Glutaryl-CoA dehydrogenase.	0.941
A0A182RBH6	A0A1I8JUT3	Transket_pyr domain-containing protein.	Aldehyde dehydrogenase family 7 member A1; Belongs to the aldehyde dehydrogenase family.	0.588
A0A182RBH6	A0A4Y0B4X2	Transket_pyr domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.643
A0A182RBH6	A0A4Y0BGW2	Transket_pyr domain-containing protein.	Aldedh domain-containing protein.	0.575
A0A182RBH6	A0A4Y0BMX4	Transket_pyr domain-containing protein.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.575
A0A182RBK3	A0A182RBH6	Lipoyl-binding domain-containing protein.	Transket_pyr domain-containing protein.	0.998
A0A182RBK3	A0A182RLJ8	Lipoyl-binding domain-containing protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.932
A0A182RBK3	A0A182RNK6	Lipoyl-binding domain-containing protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.930
A0A182RBK3	A0A182RQP2	Lipoyl-binding domain-containing protein.	Dihydrolipoyl dehydrogenase.	0.999