(20 nodes) One carbon pool by folate network (Anopheles funestus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Your Input:
	A0A182RFR0	Myb_DNA-bind_5 domain-containing protein. (530 aa)
	A0A182RJR0	Thymidylat_synt domain-containing protein. (305 aa)
	A0A182RJU7	Uncharacterized protein. (422 aa)
	A0A182RQ07	MGS domain-containing protein. (590 aa)
	A0A182RRH5	Carrier domain-containing protein; Belongs to the aldehyde dehydrogenase family. (935 aa)
	A0A182RSN4	Uncharacterized protein. (310 aa)
	A0A182RT97	Uncharacterized protein. (937 aa)
	A0A182RUF6	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (204 aa)
	A0A182RVQ1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (476 aa)
	A0A182RWU2	PNPLA domain-containing protein. (438 aa)
	A0A182RYA6	FSH1 domain-containing protein. (258 aa)
	A0A4Y0BQ31	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1382 aa)
	A0A4Y0BNW1	Uncharacterized protein. (341 aa)
	A0A4Y0BGX7	Carrier domain-containing protein; Belongs to the aldehyde dehydrogenase family. (935 aa)
	A0A4Y0B7C4	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (541 aa)
	A0A182S4P4	Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. (429 aa)
	A0A182RG19	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (414 aa)
	A0A182RHU8	Uncharacterized protein. (802 aa)
	A0A182RAF0	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (254 aa)
	A0A182REW0	Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (407 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A182RAF0	A0A182REW0	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...]	0.586
A0A182RAF0	A0A182RG19	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.944
A0A182RAF0	A0A182RJR0	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Thymidylat_synt domain-containing protein.	0.999
A0A182RAF0	A0A182RJU7	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Uncharacterized protein.	0.894
A0A182RAF0	A0A182RQ07	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	MGS domain-containing protein.	0.965
A0A182RAF0	A0A182RRH5	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Carrier domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.943
A0A182RAF0	A0A182RSN4	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Uncharacterized protein.	0.875
A0A182RAF0	A0A182RT97	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Uncharacterized protein.	0.968
A0A182RAF0	A0A182RVQ1	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.955
A0A182RAF0	A0A182RYA6	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	FSH1 domain-containing protein.	0.588
A0A182RAF0	A0A182S4P4	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.	0.512
A0A182RAF0	A0A4Y0B7C4	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.955
A0A182RAF0	A0A4Y0BGX7	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Carrier domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.943
A0A182RAF0	A0A4Y0BNW1	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Uncharacterized protein.	0.967
A0A182RAF0	A0A4Y0BQ31	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.972
A0A182REW0	A0A182RAF0	Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...]	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	0.586
A0A182REW0	A0A182RJU7	Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...]	Uncharacterized protein.	0.671
A0A182REW0	A0A182RVQ1	Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...]	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.491
A0A182REW0	A0A182S4P4	Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...]	Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.	0.993
A0A182REW0	A0A4Y0B7C4	Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...]	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.491