(23 nodes) Thiamine metabolism network (Anopheles funestus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A182R9D5	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (587 aa)
	A0A182R3P4	LMWPc domain-containing protein. (161 aa)
	A0A182R6C0	Purple acid phosphatase. (445 aa)
	A0A182R7R9	Uncharacterized protein; Belongs to the histidine acid phosphatase family. (597 aa)
	A0A182R8V1	Alkaline phosphatase. (548 aa)
	A0A182R9Q9	Aminotran_5 domain-containing protein. (445 aa)
	Adk2	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (240 aa)
	A0A182RDX2	Uncharacterized protein; Belongs to the alkaline phosphatase family. (561 aa)
	A0A182RIP2	LMWPc domain-containing protein. (155 aa)
	A0A182RJA8	Nudix hydrolase domain-containing protein. (369 aa)
	A0A182RLM5	Alkaline phosphatase. (575 aa)
	A0A182RTZ7	Alkaline phosphatase. (574 aa)
	A0A1Y9HFB6	Thiamine pyrophosphokinase. (268 aa)
	A0A4Y0BJA1	Alkaline phosphatase. (527 aa)
	A0A4Y0BMI4	Alkaline phosphatase. (570 aa)
	A0A4Y0BMZ8	Uncharacterized protein. (633 aa)
	A0A4Y0BNB1	Uncharacterized protein. (455 aa)
	A0A4Y0BNG4	Uncharacterized protein; Belongs to the adenylate kinase family. (244 aa)
	A0A4Y0BQQ9	Alkaline phosphatase. (527 aa)
	A0A4Y0BTR6	Uncharacterized protein; Belongs to the adenylate kinase family. (199 aa)
	A0A4Y0BUB9	Uncharacterized protein. (189 aa)
	A0A4Y0BV17	Uncharacterized protein. (213 aa)
	A0A4Y0BV51	Alkaline phosphatase. (530 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A182R3P4	A0A182R6C0	A0A182R3P4	A0A182R6C0	LMWPc domain-containing protein.	Purple acid phosphatase.	0.467
A0A182R3P4	A0A182RIP2	A0A182R3P4	A0A182RIP2	LMWPc domain-containing protein.	LMWPc domain-containing protein.	0.907
A0A182R3P4	A0A1Y9HFB6	A0A182R3P4	A0A1Y9HFB6	LMWPc domain-containing protein.	Thiamine pyrophosphokinase.	0.933
A0A182R3P4	A0A4Y0BMZ8	A0A182R3P4	A0A4Y0BMZ8	LMWPc domain-containing protein.	Uncharacterized protein.	0.422
A0A182R3P4	A0A4Y0BNG4	A0A182R3P4	A0A4Y0BNG4	LMWPc domain-containing protein.	Uncharacterized protein; Belongs to the adenylate kinase family.	0.422
A0A182R3P4	A0A4Y0BTR6	A0A182R3P4	A0A4Y0BTR6	LMWPc domain-containing protein.	Uncharacterized protein; Belongs to the adenylate kinase family.	0.422
A0A182R3P4	A0A4Y0BUB9	A0A182R3P4	A0A4Y0BUB9	LMWPc domain-containing protein.	Uncharacterized protein.	0.909
A0A182R3P4	A0A4Y0BV17	A0A182R3P4	A0A4Y0BV17	LMWPc domain-containing protein.	Uncharacterized protein.	0.422
A0A182R3P4	Adk2	A0A182R3P4	A0A182RB07	LMWPc domain-containing protein.	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	0.422
A0A182R6C0	A0A182R3P4	A0A182R6C0	A0A182R3P4	Purple acid phosphatase.	LMWPc domain-containing protein.	0.467
A0A182R6C0	A0A182R8V1	A0A182R6C0	A0A182R8V1	Purple acid phosphatase.	Alkaline phosphatase.	0.551
A0A182R6C0	A0A182RDX2	A0A182R6C0	A0A182RDX2	Purple acid phosphatase.	Uncharacterized protein; Belongs to the alkaline phosphatase family.	0.551
A0A182R6C0	A0A182RIP2	A0A182R6C0	A0A182RIP2	Purple acid phosphatase.	LMWPc domain-containing protein.	0.883
A0A182R6C0	A0A182RJA8	A0A182R6C0	A0A182RJA8	Purple acid phosphatase.	Nudix hydrolase domain-containing protein.	0.529
A0A182R6C0	A0A182RLM5	A0A182R6C0	A0A182RLM5	Purple acid phosphatase.	Alkaline phosphatase.	0.551
A0A182R6C0	A0A182RTZ7	A0A182R6C0	A0A182RTZ7	Purple acid phosphatase.	Alkaline phosphatase.	0.551
A0A182R6C0	A0A4Y0BJA1	A0A182R6C0	A0A4Y0BJA1	Purple acid phosphatase.	Alkaline phosphatase.	0.551
A0A182R6C0	A0A4Y0BMI4	A0A182R6C0	A0A4Y0BMI4	Purple acid phosphatase.	Alkaline phosphatase.	0.551
A0A182R6C0	A0A4Y0BMZ8	A0A182R6C0	A0A4Y0BMZ8	Purple acid phosphatase.	Uncharacterized protein.	0.511
A0A182R6C0	A0A4Y0BNB1	A0A182R6C0	A0A4Y0BNB1	Purple acid phosphatase.	Uncharacterized protein.	0.551