(38 nodes) Terpenoid backbone biosynthesis network (Anopheles funestus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A182RF58	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (433 aa)
	A0A182RDX7	Uncharacterized protein. (1308 aa)
	A0A182R7M1	SSD domain-containing protein. (924 aa)
	A0A182R6P5	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (916 aa)
	A0A182R6A9	Alkyl transferase; Belongs to the UPP synthase family. (326 aa)
	A0A182RVD8	Uncharacterized protein. (334 aa)
	A0A182RWQ7	Serine/threonine-protein kinase RIO3; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (589 aa)
	A0A182RYF0	Uncharacterized protein. (307 aa)
	A0A182RZ09	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (469 aa)
	A0A182RZ58	Uncharacterized protein. (477 aa)
	A0A1Y9HEM7	Decaprenyl-diphosphate synthase subunit. (462 aa)
	A0A1Y9HEW6	Decaprenyl-diphosphate synthase subunit; Belongs to the FPP/GGPP synthase family. (450 aa)
	A0A453YNM4	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (381 aa)
	A0A182RF95	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (245 aa)
	A0A182RTN8	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (825 aa)
	A0A182RT53	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (457 aa)
	A0A182RS97	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (285 aa)
	A0A182RS68	Uncharacterized protein. (166 aa)
	A0A182RPJ0	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (818 aa)
	A0A182RNK6	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
	A0A182RNK2	Protein-S-isoprenylcysteine O-methyltransferase. (286 aa)
	A0A182RLJ8	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (414 aa)
	A0A182RKX9	Uncharacterized protein. (272 aa)
	A0A182RJG1	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (322 aa)
	A0A182RIM6	Nudix hydrolase domain-containing protein. (244 aa)
	A0A182RIC6	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (244 aa)
	A0A182RGD8	Uncharacterized protein. (570 aa)
	A0A4Y0AUK4	Uncharacterized protein. (1314 aa)
	A0A4Y0BIE7	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (916 aa)
	A0A4Y0BJ88	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (401 aa)
	A0A4Y0BK45	Uncharacterized protein. (517 aa)
	A0A4Y0BLA1	Uncharacterized protein. (192 aa)
	A0A4Y0BLW0	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. (458 aa)
	A0A4Y0BME8	Uncharacterized protein. (114 aa)
	A0A4Y0BPF6	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (246 aa)
	A0A4Y0BPS9	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (246 aa)
	A0A4Y0BQX5	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (245 aa)
	A0A4Y0BVB7	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (214 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A182R6A9	A0A182R7M1	Alkyl transferase; Belongs to the UPP synthase family.	SSD domain-containing protein.	0.517
A0A182R6A9	A0A182RDX7	Alkyl transferase; Belongs to the UPP synthase family.	Uncharacterized protein.	0.759
A0A182R6A9	A0A182RF58	Alkyl transferase; Belongs to the UPP synthase family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.961
A0A182R6A9	A0A182RIM6	Alkyl transferase; Belongs to the UPP synthase family.	Nudix hydrolase domain-containing protein.	0.908
A0A182R6A9	A0A182RJG1	Alkyl transferase; Belongs to the UPP synthase family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.950
A0A182R6A9	A0A182RKX9	Alkyl transferase; Belongs to the UPP synthase family.	Uncharacterized protein.	0.996
A0A182R6A9	A0A182RT53	Alkyl transferase; Belongs to the UPP synthase family.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.584
A0A182R6A9	A0A182RVD8	Alkyl transferase; Belongs to the UPP synthase family.	Uncharacterized protein.	0.957
A0A182R6A9	A0A182RYF0	Alkyl transferase; Belongs to the UPP synthase family.	Uncharacterized protein.	0.584
A0A182R6A9	A0A182RZ09	Alkyl transferase; Belongs to the UPP synthase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.499
A0A182R6A9	A0A1Y9HEM7	Alkyl transferase; Belongs to the UPP synthase family.	Decaprenyl-diphosphate synthase subunit.	0.930
A0A182R6A9	A0A1Y9HEW6	Alkyl transferase; Belongs to the UPP synthase family.	Decaprenyl-diphosphate synthase subunit; Belongs to the FPP/GGPP synthase family.	0.930
A0A182R6A9	A0A453YNM4	Alkyl transferase; Belongs to the UPP synthase family.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.780
A0A182R6A9	A0A4Y0AUK4	Alkyl transferase; Belongs to the UPP synthase family.	Uncharacterized protein.	0.759
A0A182R6A9	A0A4Y0BJ88	Alkyl transferase; Belongs to the UPP synthase family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.934
A0A182R6A9	A0A4Y0BK45	Alkyl transferase; Belongs to the UPP synthase family.	Uncharacterized protein.	0.934
A0A182R6A9	A0A4Y0BLW0	Alkyl transferase; Belongs to the UPP synthase family.	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	0.961
A0A182R6P5	A0A182RT53	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.419
A0A182R7M1	A0A182R6A9	SSD domain-containing protein.	Alkyl transferase; Belongs to the UPP synthase family.	0.517
A0A182R7M1	A0A182RDX7	SSD domain-containing protein.	Uncharacterized protein.	0.629