(112 nodes) MAPK signaling pathway - fly network (Anopheles funestus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A182RDC3	Uncharacterized protein. (725 aa)
	A0A182RE23	Uncharacterized protein. (292 aa)
	A0A182RF40	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (118 aa)
	A0A182RFH5	PH domain-containing protein. (912 aa)
	A0A182RFJ7	TGF_BETA_2 domain-containing protein. (573 aa)
	A0A182RFP9	14-3-3 zeta; Belongs to the 14-3-3 family. (248 aa)
	A0A182RG36	C2H2-type domain-containing protein. (447 aa)
	A0A182RG40	Uncharacterized protein. (1284 aa)
	A0A182RG65	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (395 aa)
	A0A182RGB3	Mitogen-activated protein kinase. (387 aa)
	A0A182RGB4	Mitogen-activated protein kinase. (376 aa)
	A0A182RH15	Uncharacterized protein. (190 aa)
	A0A182RH59	Uncharacterized protein. (981 aa)
	A0A182RHF1	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (126 aa)
	A0A182RHT9	MADS-box domain-containing protein. (576 aa)
	A0A182RHX7	Uncharacterized protein. (2199 aa)
	A0A182RIE6	HMG box domain-containing protein. (3153 aa)
	A0A182RJC8	Uncharacterized protein. (504 aa)
	A0A182RD46	Uncharacterized protein. (1419 aa)
	A0A182RCS5	PPM-type phosphatase domain-containing protein. (368 aa)
	A0A182RCG2	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (110 aa)
	A0A182RC61	Uncharacterized protein. (411 aa)
	A0A182RC06	Uncharacterized protein. (192 aa)
	A0A182RAU9	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (508 aa)
	A0A182RAT0	Uncharacterized protein. (879 aa)
	A0A182RA98	PNT domain-containing protein. (143 aa)
	A0A182R9K7	Ig-like domain-containing protein. (815 aa)
	A0A182R9A7	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (515 aa)
	A0A182R8H1	DSPc domain-containing protein. (274 aa)
	A0A182R8B9	Uncharacterized protein. (891 aa)
	A0A182R7S1	Serine/threonine-protein phosphatase. (309 aa)
	A0A182R6J5	Uncharacterized protein. (1826 aa)
	A0A182R6I6	Uncharacterized protein. (1862 aa)
	A0A182R656	Uncharacterized protein. (195 aa)
	A0A182R5K0	BZIP domain-containing protein. (318 aa)
	A0A182R533	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (406 aa)
	A0A182R516	Uncharacterized protein. (1210 aa)
	A0A182R4M4	Uncharacterized protein. (481 aa)
	A0A182R465	Uncharacterized protein. (1015 aa)
	A0A182R3F9	TNFR-Cys domain-containing protein. (315 aa)
	A0A182R342	Uncharacterized protein. (239 aa)
	A0A182R2W3	Uncharacterized protein. (685 aa)
	A0A182R250	Uncharacterized protein. (259 aa)
	A0A182R222	Tyrosine-protein kinase receptor. (2512 aa)
	A0A182R1G8	Protein kinase domain-containing protein. (1128 aa)
	W6FTC9_ANOFN	14-3-3 zeta; Belongs to the 14-3-3 family. (248 aa)
	A0A4Y0BTF1	Uncharacterized protein. (420 aa)
	A0A4Y0BRP9	ETS domain-containing protein. (579 aa)
	A0A4Y0BR29	Runt domain-containing protein. (683 aa)
	A0A4Y0BPZ0	Uncharacterized protein. (734 aa)
	A0A4Y0BP24	Tyrosine-protein kinase. (808 aa)
	A0A4Y0BN26	Uncharacterized protein. (211 aa)
	A0A4Y0BN04	Uncharacterized protein. (745 aa)
	A0A4Y0BMK3	Uncharacterized protein. (884 aa)
	A0A4Y0BMA7	Prospero domain-containing protein. (1821 aa)
	A0A4Y0BLX7	WD_REPEATS_REGION domain-containing protein. (755 aa)
	A0A4Y0BLS2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (392 aa)
	A0A4Y0BLM4	Uncharacterized protein. (776 aa)
	A0A4Y0BL60	MACPF domain-containing protein. (377 aa)
	A0A4Y0BL27	Uncharacterized protein. (510 aa)
	A0A4Y0BK79	Tyrosine-protein kinase. (676 aa)
	A0A4Y0BJJ7	Protein kinase domain-containing protein. (1545 aa)
	A0A4Y0BJJ5	Tyrosine-protein kinase. (641 aa)
	A0A4Y0BJE7	Uncharacterized protein. (2594 aa)
	A0A4Y0BJ45	Uncharacterized protein. (711 aa)
	A0A4Y0BJ12	Tyrosine-protein kinase. (508 aa)
	A0A4Y0BIF9	Uncharacterized protein. (620 aa)
	A0A4Y0BIF2	Mitogen-activated protein kinase. (358 aa)
	A0A4Y0BID7	Uncharacterized protein. (769 aa)
	A0A4Y0BHE1	Uncharacterized protein. (1511 aa)
	A0A4Y0BHA0	Importin N-terminal domain-containing protein. (1053 aa)
	A0A4Y0BH90	Runt domain-containing protein. (765 aa)
	A0A4Y0BH85	Uncharacterized protein. (1552 aa)
	A0A4Y0BGP8	Uncharacterized protein. (548 aa)
	A0A4Y0BFA5	Tyrosine-protein kinase. (1170 aa)
	A0A4Y0BD16	PPM-type phosphatase domain-containing protein. (368 aa)
	A0A4Y0B9D6	BZIP domain-containing protein. (444 aa)
	A0A4Y0B745	BZIP domain-containing protein. (515 aa)
	A0A4Y0B291	Uncharacterized protein. (778 aa)
	A0A4Y0B206	Receptor protein-tyrosine kinase. (1488 aa)
	A0A4Y0B0X2	Protein kinase domain-containing protein. (597 aa)
	A0A4Y0AXF8	HMG box domain-containing protein. (3108 aa)
	A0A4Y0AQ35	Uncharacterized protein. (812 aa)
	A0A4Y0ALV6	Uncharacterized protein. (1238 aa)
	A0A453YNH5	FAD-binding FR-type domain-containing protein. (392 aa)
	A0A1Y9HE64	Uncharacterized protein. (566 aa)
	A0A182RYG5	Protein kinase domain-containing protein. (1573 aa)
	A0A182RXB6	Uncharacterized protein. (196 aa)
	A0A182RX75	G_PROTEIN_RECEP_F3_4 domain-containing protein. (1062 aa)
	A0A182RWZ8	Uncharacterized protein. (758 aa)
	A0A182RWS0	Uncharacterized protein. (1509 aa)
	A0A182RW87	Tyrosine-protein kinase. (1170 aa)
	A0A182RVX1	BZIP domain-containing protein. (458 aa)
	A0A182RTZ6	Importin N-terminal domain-containing protein. (1055 aa)
	A0A182RT13	Uncharacterized protein. (948 aa)
	A0A182RS98	EGF-like domain-containing protein. (269 aa)
	A0A182RRY4	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (523 aa)
	A0A182RRF9	Nuclear receptor domain-containing protein. (107 aa)
	A0A182RRF8	NR LBD domain-containing protein. (505 aa)
	A0A182RR66	Tyrosine-protein kinase. (537 aa)
	A0A182RQY7	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (306 aa)
	A0A182RQ14	Uncharacterized protein. (275 aa)
	A0A182RPP5	Receptor protein-tyrosine kinase. (1465 aa)
	A0A182RPF5	Uncharacterized protein. (719 aa)
	A0A182RP56	Uncharacterized protein. (2134 aa)
	A0A182RNS2	Uncharacterized protein. (381 aa)
	A0A182RNC9	Uncharacterized protein. (248 aa)
	A0A182RMU4	Uncharacterized protein. (1868 aa)
	A0A182RMT5	Uncharacterized protein. (562 aa)
	A0A182RMS8	NR LBD domain-containing protein. (325 aa)
	A0A182RM62	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (380 aa)
	A0A182RLS9	Uncharacterized protein. (469 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A182R1G8	A0A182R222	A0A182R1G8	A0A182R222	Protein kinase domain-containing protein.	Tyrosine-protein kinase receptor.	0.480
A0A182R1G8	A0A182R2W3	A0A182R1G8	A0A182R2W3	Protein kinase domain-containing protein.	Uncharacterized protein.	0.544
A0A182R1G8	A0A182R465	A0A182R1G8	A0A182R465	Protein kinase domain-containing protein.	Uncharacterized protein.	0.964
A0A182R1G8	A0A182R516	A0A182R1G8	A0A182R516	Protein kinase domain-containing protein.	Uncharacterized protein.	0.664
A0A182R1G8	A0A182R5K0	A0A182R1G8	A0A182R5K0	Protein kinase domain-containing protein.	BZIP domain-containing protein.	0.663
A0A182R1G8	A0A182R656	A0A182R1G8	A0A182R656	Protein kinase domain-containing protein.	Uncharacterized protein.	0.666
A0A182R1G8	A0A182R8H1	A0A182R1G8	A0A182R8H1	Protein kinase domain-containing protein.	DSPc domain-containing protein.	0.880
A0A182R1G8	A0A182R9A7	A0A182R1G8	A0A182R9A7	Protein kinase domain-containing protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.540
A0A182R1G8	A0A182RAU9	A0A182R1G8	A0A182RAU9	Protein kinase domain-containing protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.586
A0A182R1G8	A0A182RC06	A0A182R1G8	A0A182RC06	Protein kinase domain-containing protein.	Uncharacterized protein.	0.666
A0A182R1G8	A0A182RCG2	A0A182R1G8	A0A182RCG2	Protein kinase domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.592
A0A182R1G8	A0A182RCS5	A0A182R1G8	A0A182RCS5	Protein kinase domain-containing protein.	PPM-type phosphatase domain-containing protein.	0.681
A0A182R1G8	A0A182RD46	A0A182R1G8	A0A182RD46	Protein kinase domain-containing protein.	Uncharacterized protein.	0.586
A0A182R1G8	A0A182RG65	A0A182R1G8	A0A182RG65	Protein kinase domain-containing protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.567
A0A182R1G8	A0A182RGB3	A0A182R1G8	A0A182RGB3	Protein kinase domain-containing protein.	Mitogen-activated protein kinase.	0.991
A0A182R1G8	A0A182RGB4	A0A182R1G8	A0A182RGB4	Protein kinase domain-containing protein.	Mitogen-activated protein kinase.	0.991
A0A182R1G8	A0A182RH15	A0A182R1G8	A0A182RH15	Protein kinase domain-containing protein.	Uncharacterized protein.	0.553
A0A182R1G8	A0A182RNC9	A0A182R1G8	A0A182RNC9	Protein kinase domain-containing protein.	Uncharacterized protein.	0.972
A0A182R1G8	A0A182RNS2	A0A182R1G8	A0A182RNS2	Protein kinase domain-containing protein.	Uncharacterized protein.	0.664
A0A182R1G8	A0A182RR66	A0A182R1G8	A0A182RR66	Protein kinase domain-containing protein.	Tyrosine-protein kinase.	0.472