(33 nodes) Hedgehog signaling pathway - fly network (Anopheles funestus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A4Y0BJK9	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (516 aa)
	A0A4Y0BIJ6	Protein kinase domain-containing protein. (803 aa)
	A0A4Y0BHQ1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (479 aa)
	A0A4Y0BGP5	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (1127 aa)
	A0A4Y0BG40	Protein kinase domain-containing protein. (835 aa)
	A0A4Y0BE73	Uncharacterized protein; Belongs to the protein kinase superfamily. (353 aa)
	A0A2C9GWR0	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (651 aa)
	A0A1Y9HFF6	Cullin; Belongs to the cullin family. (779 aa)
	A0A1Y9HEJ5	Casein kinase 1, gamma; Belongs to the protein kinase superfamily. (467 aa)
	A0A1Y9HEA0	Casein kinase 1, gamma; Belongs to the protein kinase superfamily. (461 aa)
	A0A1Y9HDN9	Casein kinase 1, gamma. (502 aa)
	A0A182RYX4	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1085 aa)
	A0A182RXM4	Uncharacterized protein. (1198 aa)
	A0A182RXK6	Uncharacterized protein. (600 aa)
	A0A182RXK3	Suppressor of fused homolog. (464 aa)
	A0A182RX16	RING-type domain-containing protein. (109 aa)
	A0A182RWI2	CULLIN_2 domain-containing protein; Belongs to the cullin family. (778 aa)
	A0A182RVW7	Uncharacterized protein; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (425 aa)
	A0A182RR85	BTB domain-containing protein. (616 aa)
	A0A182RQT2	SSD domain-containing protein. (1335 aa)
	A0A182RMU8	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (331 aa)
	A0A182RK93	Uncharacterized protein. (1261 aa)
	A0A182RK65	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (1126 aa)
	A0A182RFJ7	TGF_BETA_2 domain-containing protein. (573 aa)
	A0A182RE89	Uncharacterized protein. (1713 aa)
	A0A182RDP9	BTB domain-containing protein. (636 aa)
	A0A182RC59	Homeobox protein engrailed-like. (175 aa)
	A0A182RC58	Homeobox protein engrailed-like. (565 aa)
	A0A182R699	Uncharacterized protein. (1166 aa)
	A0A182R406	Uncharacterized protein; Belongs to the SKP1 family. (162 aa)
	A0A4Y0BS05	Protein kinase domain-containing protein. (521 aa)
	A0A4Y0BMP5	Uncharacterized protein. (531 aa)
	A0A4Y0BL73	Uncharacterized protein. (375 aa)

Your Current Organism:

Anopheles funestus

NCBI taxonomy Id: 62324
Other names: A. funestus

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A182R406	A0A182RDP9	Uncharacterized protein; Belongs to the SKP1 family.	BTB domain-containing protein.	0.493
A0A182R406	A0A182RE89	Uncharacterized protein; Belongs to the SKP1 family.	Uncharacterized protein.	0.924
A0A182R406	A0A182RMU8	Uncharacterized protein; Belongs to the SKP1 family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.759
A0A182R406	A0A182RR85	Uncharacterized protein; Belongs to the SKP1 family.	BTB domain-containing protein.	0.493
A0A182R406	A0A182RWI2	Uncharacterized protein; Belongs to the SKP1 family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.999
A0A182R406	A0A182RX16	Uncharacterized protein; Belongs to the SKP1 family.	RING-type domain-containing protein.	0.999
A0A182R406	A0A182RXK3	Uncharacterized protein; Belongs to the SKP1 family.	Suppressor of fused homolog.	0.618
A0A182R406	A0A182RXK6	Uncharacterized protein; Belongs to the SKP1 family.	Uncharacterized protein.	0.997
A0A182R406	A0A1Y9HFF6	Uncharacterized protein; Belongs to the SKP1 family.	Cullin; Belongs to the cullin family.	0.983
A0A182R406	A0A4Y0BG40	Uncharacterized protein; Belongs to the SKP1 family.	Protein kinase domain-containing protein.	0.694
A0A182R406	A0A4Y0BHQ1	Uncharacterized protein; Belongs to the SKP1 family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.694
A0A182R406	A0A4Y0BIJ6	Uncharacterized protein; Belongs to the SKP1 family.	Protein kinase domain-containing protein.	0.694
A0A182R699	A0A182RK65	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.746
A0A182R699	A0A182RQT2	Uncharacterized protein.	SSD domain-containing protein.	0.973
A0A182R699	A0A182RYX4	Uncharacterized protein.	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.416
A0A182R699	A0A4Y0BGP5	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.746
A0A182R699	A0A4Y0BJK9	Uncharacterized protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.997
A0A182RC58	A0A182RC59	Homeobox protein engrailed-like.	Homeobox protein engrailed-like.	0.872
A0A182RC58	A0A4Y0BJK9	Homeobox protein engrailed-like.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.442
A0A182RC59	A0A182RC58	Homeobox protein engrailed-like.	Homeobox protein engrailed-like.	0.872