STRINGSTRING
her-1 her-1 fem-1 fem-1 tra-3 tra-3 fem-2 fem-2 tra-2 tra-2 tra-1 tra-1 fem-3 fem-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
her-1Protein CBR-HER-1. (174 aa)
fem-1Protein CBR-FEM-1. (660 aa)
tra-3Protein CBR-TRA-3; Belongs to the peptidase C2 family. (646 aa)
fem-2Putative PP2C protein phosphatase FEM-2. (502 aa)
tra-2Sex-determining transformer protein 2; Plays a major role in controlling sexual cell fates. Promotes female development in XX animals where it sequesters one or more of the FEM proteins to the membrane thereby freeing the tra-1 protein (a putative transcription factor) to enter the nucleus and promote female development (By similarity). In XO animals it acts as a receptor for her-1 which prevents it from binding to FEM proteins thereby repressing the activity of tra-1 (By similarity). Negatively regulates male development when bound to fem-3 and is required together with tra-1 for prom [...] (1489 aa)
tra-1Sex-determining transformer protein 1; Plays a major role in controlling sexual phenotype. Terminal global regulator in a well-characterized cascade of sex-determining genes (By similarity). Promotes female development (By similarity). Interacts with tra-2 to promote spermatogenesis. Promotes spermatogenesis through the Tip60 HAT complex and by regulating the expression of genes, such as fog-3, required for male development. Association with chromatin and at the fog-3 promoter requires wdr-5.1, and may also require wdr-5.2 (By similarity). With trr-1, activates the fog-3 gene to determ [...] (1165 aa)
fem-3Sex-determination protein fem-3; Required for male development. In XO (male) animals, fem-3 directs male differentiation in all tissues. In XX (hermaphrodite animals), it specifies the first 80 or so germ cells to be sperm. Negatively regulates male development when bound to tra-2. (409 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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