STRINGSTRING
par-5 par-5 daf-16 daf-16 ftt-2 ftt-2 hsf-1 hsf-1 hda-10 hda-10 sir-2.1 sir-2.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
par-5Protein CBR-PAR-5; Belongs to the 14-3-3 family. (248 aa)
daf-16Protein CBR-DAF-16. (497 aa)
ftt-2Protein CBR-FTT-2; Belongs to the 14-3-3 family. (248 aa)
hsf-1Protein CBR-HSF-1. (504 aa)
hda-10Protein CBR-HDA-6. (506 aa)
sir-2.1NAD-dependent protein deacetylase sir-2.1; NAD-dependent deacetylase. Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites. Functions upstream of daf-16 in the insulin-like signaling pathway, promoting daf-16 mediated transcriptional activation and increased life-span. May also regulate life-span independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticulum (ER). Acts upstream of the nicotinic acid metabolism pathway, which may be linked to the r [...] (602 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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