(33 nodes) Protein targeting to mitochondrion, and SAM complex network (Caenorhabditis briggsae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CBG23654	Protein CBG23654. (78 aa)
	CBG23912	Protein CBG23912. (219 aa)
	mtx-2	Protein CBR-MTX-2. (244 aa)
	tctn-1	Protein CBR-TCTN-1. (386 aa)
	timm-17b.1	Mitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (181 aa)
	CBG02935	Protein CBG02935. (214 aa)
	romo-1	Protein CBR-RMO-1. (83 aa)
	tomm-70	Protein CBG06925. (571 aa)
	tomm-22	Protein CBR-TOMM-22. (109 aa)
	CBG08678	Protein CBG08678. (335 aa)
	hsp-6	Protein CBR-HSP-6; Belongs to the heat shock protein 70 family. (658 aa)
	CBG09795	GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family. (237 aa)
	tomm-7	Protein CBR-TOMM-7. (58 aa)
	tin-13	Protein CBR-TIN-13; Belongs to the small Tim family. (108 aa)
	tin-44	Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family. (425 aa)
	hlh-33	Protein CBR-HLH-33. (339 aa)
	CBG15187	Protein CBG15187. (45 aa)
	timm-23	Protein CBG15355. (243 aa)
	CBG15379	Protein CBG15379. (65 aa)
	CBG16918	Protein CBG16918. (127 aa)
	CBG18121	Protein CBG18121. (119 aa)
	mtx-1	Metaxin-1 homolog; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity). (312 aa)
	CBG19950	Protein CBG19950. (97 aa)
	gop-3	Protein CBR-GOP-3. (407 aa)
	CBG22010	Sulfhydryl oxidase. (162 aa)
	tomm-20	Mitochondrial import receptor subunit TOM20 homolog; Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore (By similarity). (188 aa)
	CBG21207	Mitochondrial import inner membrane translocase subunit tim-16; Regulates ATP-dependent protein translocation into the mitochondrial matrix; Belongs to the TIM16/PAM16 family. (138 aa)
	ddp-1	Mitochondrial import inner membrane translocase subunit Tim8; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The ddp- 1/tim-8-tim-13 complex mediates the import of some [...] (83 aa)
	dnj-21	Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). (111 aa)
	tin-10	Mitochondrial import inner membrane translocase subunit Tim10; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity); Belongs to the small Tim family. (86 aa)
	scpl-4	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (456 aa)
	tin-9.1	Mitochondrial import inner membrane translocase subunit Tim9; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity); Belongs to the small Tim family. (78 aa)
	tomm-40	Mitochondrial import receptor subunit TOM40 homolog; Channel-forming protein essential for import of protein precursors into mitochondria. Specifically required for nnt-1 accumulation in the mitochondria and may be involved in the secretion of daf-28/insulin from the mitochondria. Required for embryonic and larval development. (301 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG02935	CBG09795	A8WT64	A8X9N2	Protein CBG02935.	GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family.	0.532
CBG02935	CBG15187	A8WT64	A8XLQ9	Protein CBG02935.	Protein CBG15187.	0.499
CBG02935	CBG16918	A8WT64	A8XQ19	Protein CBG02935.	Protein CBG16918.	0.800
CBG02935	CBG18121	A8WT64	A8XT25	Protein CBG02935.	Protein CBG18121.	0.800
CBG02935	CBG19950	A8WT64	A8XWS7	Protein CBG02935.	Protein CBG19950.	0.818
CBG02935	CBG21207	A8WT64	Q60RS2	Protein CBG02935.	Mitochondrial import inner membrane translocase subunit tim-16; Regulates ATP-dependent protein translocation into the mitochondrial matrix; Belongs to the TIM16/PAM16 family.	0.623
CBG02935	CBG23912	A8WT64	A8WJK3	Protein CBG02935.	Protein CBG23912.	0.662
CBG02935	ddp-1	A8WT64	Q616Q2	Protein CBG02935.	Mitochondrial import inner membrane translocase subunit Tim8; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The ddp- 1/tim-8-tim-13 complex mediates the import of some [...]	0.600
CBG02935	dnj-21	A8WT64	Q617M0	Protein CBG02935.	Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).	0.701
CBG02935	hlh-33	A8WT64	A8XLE6	Protein CBG02935.	Protein CBR-HLH-33.	0.600
CBG02935	scpl-4	A8WT64	Q61JS7	Protein CBG02935.	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	0.627
CBG02935	tctn-1	A8WT64	A8WQY4	Protein CBG02935.	Protein CBR-TCTN-1.	0.756
CBG02935	timm-17b.1	A8WT64	A8WQY5	Protein CBG02935.	Mitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	0.765
CBG02935	timm-23	A8WT64	A8XM09	Protein CBG02935.	Protein CBG15355.	0.935
CBG02935	tin-10	A8WT64	Q61BP6	Protein CBG02935.	Mitochondrial import inner membrane translocase subunit Tim10; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity); Belongs to the small Tim family.	0.992
CBG02935	tin-13	A8WT64	A8XF90	Protein CBG02935.	Protein CBR-TIN-13; Belongs to the small Tim family.	0.684
CBG02935	tin-44	A8WT64	A8XG07	Protein CBG02935.	Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family.	0.613
CBG02935	tin-9.1	A8WT64	Q61TH2	Protein CBG02935.	Mitochondrial import inner membrane translocase subunit Tim9; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity); Belongs to the small Tim family.	0.993
CBG02935	tomm-22	A8WT64	A8X3S5	Protein CBG02935.	Protein CBR-TOMM-22.	0.504
CBG02935	tomm-40	A8WT64	Q61Z83	Protein CBG02935.	Mitochondrial import receptor subunit TOM40 homolog; Channel-forming protein essential for import of protein precursors into mitochondria. Specifically required for nnt-1 accumulation in the mitochondria and may be involved in the secretion of daf-28/insulin from the mitochondria. Required for embryonic and larval development.	0.692