(70 nodes) Purine metabolism, and Pyrimidine-containing compound biosynthetic process network (Caenorhabditis briggsae)

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	CBG23577	Protein CBG23577. (515 aa)
	CBG23625	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (358 aa)
	ctps-1	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (674 aa)
	gcy-18	Guanylate cyclase. (1145 aa)
	upp-1	Protein CBG00006. (329 aa)
	dtmk-1	Protein CBG01006. (169 aa)
	CBG00957	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily. (189 aa)
	gcy-5	Guanylate cyclase. (1242 aa)
	CBG01514	Protein CBG01514. (187 aa)
	CBG02038	Protein CBG02038. (554 aa)
	ndk-1	Nucleoside diphosphate kinase. (153 aa)
	CBG03104	Protein CBG03104; Belongs to the adenylate kinase family. (222 aa)
	gmps-1	Protein CBG03001. (808 aa)
	CBG02961	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (191 aa)
	CBG02610	Protein CBG02610. (381 aa)
	CBG02609	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (122 aa)
	CBG02379	Protein CBG02379. (303 aa)
	gcy-12	Guanylate cyclase. (1690 aa)
	ampd-1	Protein CBG02349. (1030 aa)
	CBG03314	Uridine kinase; Belongs to the uridine kinase family. (555 aa)
	CBG04101	Protein CBG04101. (367 aa)
	dut-1	Protein CBR-DUT-1. (487 aa)
	thk-1	Thymidine kinase. (273 aa)
	gcy-14	Guanylate cyclase. (1125 aa)
	CBG05336	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (191 aa)
	CBG06237	Protein CBG06237. (248 aa)
	CBG06032	Protein CBG06032. (342 aa)
	cdd-2	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (166 aa)
	CBG05751	Protein CBG05751. (360 aa)
	CBG05749	Protein CBG05749. (407 aa)
	CBG05718	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (534 aa)
	pde-2	Phosphodiesterase. (959 aa)
	CBG06863	Protein CBG06863. (200 aa)
	CBG06909	Protein CBG06909. (307 aa)
	CBG07940	Protein CBG07940. (222 aa)
	CBG09035	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (309 aa)
	CBG09150	Protein CBG09150. (153 aa)
	rnr-1	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (790 aa)
	CBG10474	Guanylate cyclase. (782 aa)
	uda-1	Protein CBR-UDA-1; Belongs to the GDA1/CD39 NTPase family. (304 aa)
	guk-1	Protein CBR-GUK-1. (216 aa)
	pde-5	Phosphodiesterase. (715 aa)
	CBG12968	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (285 aa)
	pdl-1	Phosphodiesterase delta-like protein; Belongs to the PDE6D/unc-119 family. (159 aa)
	CBG13197	Protein CBG13197. (340 aa)
	CBG13218	Protein CBG13218. (293 aa)
	CBG13501	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (301 aa)
	ndx-4	Protein CBR-NDX-4. (137 aa)
	CBG13827	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (301 aa)
	CBG14198	Protein CBG14198. (349 aa)
	CBG14916	Protein CBG14916. (185 aa)
	apy-1	Protein CBG16731. (354 aa)
	CBG16977	Protein CBG16977. (210 aa)
	CBG17377	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (210 aa)
	CBG17473	Protein CBG17473. (205 aa)
	CBG18226	Protein CBG18226. (168 aa)
	pde-6	Phosphodiesterase. (705 aa)
	CBG19432	Protein CBG19432; Belongs to the GDA1/CD39 NTPase family. (216 aa)
	CBG19806	Protein CBG19806. (229 aa)
	hprt-1	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (214 aa)
	lntl-1	Protein CBR-LNTL-1. (306 aa)
	rnr-2	Protein CBR-RNR-2. (365 aa)
	pde-1	Phosphodiesterase. (662 aa)
	pde-3	Phosphodiesterase. (504 aa)
	let-754	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (257 aa)
	hap-1	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (184 aa)
	xdh-1	Protein CBG21624. (1363 aa)
	cdd-1	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (158 aa)
	CBG23391	Protein CBG23391. (690 aa)
	mig-23	Nucleoside-diphosphatase mig-23; Seems to be able to hydrolyze ADP, UDP and GDP. Supports mig- 17 glycosylation and surface expression, which is required for proper migration of distal tip cells during gonad morphogenesis (By similarity). (553 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG00957	CBG02038	A8WP87	A8WRV3	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily.	Protein CBG02038.	0.900
CBG00957	CBG03104	A8WP87	A8WSS5	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily.	Protein CBG03104; Belongs to the adenylate kinase family.	0.933
CBG00957	CBG06032	A8WP87	A8X122	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily.	Protein CBG06032.	0.916
CBG00957	CBG09035	A8WP87	A8X7Z0	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily.	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family.	0.900
CBG00957	CBG13827	A8WP87	A8XIS7	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily.	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family.	0.900
CBG00957	CBG14916	A8WP87	A8XKZ6	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily.	Protein CBG14916.	0.905
CBG00957	CBG17377	A8WP87	A8XQX9	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily.	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	0.972
CBG00957	CBG23391	A8WP87	A8Y412	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily.	Protein CBG23391.	0.906
CBG00957	ampd-1	A8WP87	A8WUJ0	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily.	Protein CBG02349.	0.900
CBG00957	hap-1	A8WP87	A8XZP2	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.706
CBG00957	let-754	A8WP87	A8XZJ0	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily.	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	0.933
CBG00957	ndk-1	A8WP87	A8WS68	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily.	Nucleoside diphosphate kinase.	0.933
CBG00957	pde-1	A8WP87	A8XXM1	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily.	Phosphodiesterase.	0.900
CBG00957	pde-3	A8WP87	A8XYV6	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily.	Phosphodiesterase.	0.900
CBG00957	pde-5	A8WP87	A8XFQ4	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily.	Phosphodiesterase.	0.900
CBG00957	pde-6	A8WP87	A8XTJ4	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily.	Phosphodiesterase.	0.900
CBG00957	rnr-1	A8WP87	A8XAI1	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.981
CBG00957	rnr-2	A8WP87	A8XX72	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily.	Protein CBR-RNR-2.	0.900
CBG01514	CBG05718	A8WQI4	A8X1T4	Protein CBG01514.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	0.829
CBG01514	CBG06909	A8WQI4	A8X3C3	Protein CBG01514.	Protein CBG06909.	0.579