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goa-1 goa-1 nhr-17 nhr-17 gcy-25 gcy-25 npr-26 npr-26 nlp-5 nlp-5 CBG00653 CBG00653 Cbr-gcy-1 Cbr-gcy-1 slc-17.1 slc-17.1 npr-24 npr-24 nlp-6 nlp-6 ser-7 ser-7 gcy-31 gcy-31 rgs-3 rgs-3 gcy-17 gcy-17 homt-1 homt-1 ser-5 ser-5 mod-5 mod-5 eat-16 eat-16 npr-34 npr-34 rhgf-1 rhgf-1 CBG04553 CBG04553 gar-3 gar-3 gcy-32 gcy-32 gar-1 gar-1 gcy-22 gcy-22 CBG06559 CBG06559 gcy-34 gcy-34 tax-4 tax-4 nmur-2 nmur-2 CBG07754 CBG07754 gcy-36 gcy-36 ser-2 ser-2 odr-1 odr-1 CBG07423 CBG07423 npr-14 npr-14 dop-4 dop-4 ncs-3 ncs-3 arr-1 arr-1 egl-4 egl-4 ntr-1 ntr-1 CBG08997 CBG08997 acy-3 acy-3 nhr-47 nhr-47 glb-5 glb-5 acy-4 acy-4 acy-2 acy-2 gpa-17 gpa-17 Cbr-gpr-2 Cbr-gpr-2 dat-1 dat-1 npr-15 npr-15 Cbr-rgs-4 Cbr-rgs-4 tyra-2 tyra-2 CBG11217 CBG11217 cng-1 cng-1 gpb-2 gpb-2 CBG12105 CBG12105 CBG12208 CBG12208 tax-2 tax-2 CBG12846 CBG12846 ckr-1 ckr-1 ser-3 ser-3 lgc-55 lgc-55 pde-4 pde-4 npr-31 npr-31 CBG13879 CBG13879 gcy-37 gcy-37 rgs-7 rgs-7 CBG14305 CBG14305 dop-1 dop-1 nmur-3 nmur-3 ntc-1 ntc-1 tyra-3 tyra-3 rgs-6 rgs-6 gnrr-4 gnrr-4 kin-2 kin-2 ckr-2 ckr-2 ser-4 ser-4 grk-2 grk-2 pkg-2 pkg-2 npr-18 npr-18 npr-21 npr-21 CBG15937 CBG15937 ser-1 ser-1 cng-2 cng-2 gcy-9 gcy-9 npr-9 npr-9 acy-1 acy-1 CBG18556 CBG18556 mod-1 mod-1 dop-2 dop-2 CBG19453 CBG19453 gcy-21 gcy-21 CBG19820 CBG19820 kin-1 kin-1 gpa-18 gpa-18 gcy-35 gcy-35 CBG20391 CBG20391 CBG20392 CBG20392 CBG20633 CBG20633 CBG20722 CBG20722 CBG20723 CBG20723 CBG20724 CBG20724 CBG20725 CBG20725 CBG25106 CBG25106 ador-1 ador-1 gpa-11 gpa-11 gsa-1 gsa-1 nlp-12 nlp-12 egl-30 egl-30 CBG22517 CBG22517 npr-28 npr-28 npr-17 npr-17 egl-10 egl-10 gcy-33 gcy-33 daf-11 daf-11 dop-5 dop-5 npr-25 npr-25 CBG25427 CBG25427 CBG25672 CBG25672 gpc-2 gpc-2 gpc-1 gpc-1 gpa-6 gpa-6 gpa-14 gpa-14 gpa-13 gpa-13 gpa-10 gpa-10 gpa-1 gpa-1 gpa-3 gpa-3 gpa-16 gpa-16 gpa-12 gpa-12 gpa-5 gpa-5 ric-8 ric-8 gpa-4 gpa-4 gpa-15 gpa-15 dop-3 dop-3 gpa-8 gpa-8 gpa-7 gpa-7 gpb-1 gpb-1 grk-1 grk-1 odr-3 odr-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
goa-1Protein CBR-GOA-1. (323 aa)
nhr-17Protein CBR-NHR-17. (398 aa)
gcy-25Guanylate cyclase. (1066 aa)
npr-26Protein CBG00382; Belongs to the G-protein coupled receptor 1 family. (454 aa)
nlp-5Protein CBR-NLP-5. (122 aa)
CBG00653Protein CBG00653. (1366 aa)
Cbr-gcy-1Guanylate cyclase. (957 aa)
slc-17.1Protein CBG01860. (474 aa)
npr-24Protein CBG01863; Belongs to the G-protein coupled receptor 1 family. (369 aa)
nlp-6Protein CBR-NLP-6. (85 aa)
ser-7Protein CBR-SER-7; Belongs to the G-protein coupled receptor 1 family. (427 aa)
gcy-31Protein CBR-GCY-31; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (713 aa)
rgs-3Protein CBR-RGS-3. (364 aa)
gcy-17Guanylate cyclase. (1095 aa)
homt-1Alpha N-terminal protein methyltransferase 1; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif (By similarity); Belongs to the methyltransferase superfamily. NTM1 family. (231 aa)
ser-5Protein CBR-SER-5; Belongs to the G-protein coupled receptor 1 family. (494 aa)
mod-5Protein CBR-MOD-5. (671 aa)
eat-16Protein CBR-EAT-16. (485 aa)
npr-34Protein CBG04262; Belongs to the G-protein coupled receptor 1 family. (616 aa)
rhgf-1Protein CBR-RHGF-1. (1376 aa)
CBG04553Protein CBG04553. (1075 aa)
gar-3Protein CBR-GAR-3; Belongs to the G-protein coupled receptor 1 family. (609 aa)
gcy-32Protein CBG04937; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (683 aa)
gar-1Protein CBR-GAR-1; Belongs to the G-protein coupled receptor 1 family. (712 aa)
gcy-22Guanylate cyclase. (1076 aa)
CBG06559Guanylate cyclase. (1291 aa)
gcy-34Protein CBR-GCY-34; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (686 aa)
tax-4Protein CBR-TAX-4. (726 aa)
nmur-2Protein CBR-NMUR-2; Belongs to the G-protein coupled receptor 1 family. (412 aa)
CBG07754Protein CBG07754. (318 aa)
gcy-36Protein CBR-GCY-36; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (759 aa)
ser-2Protein CBR-SER-2; Belongs to the G-protein coupled receptor 1 family. (475 aa)
odr-1Protein CBR-ODR-1. (609 aa)
CBG07423Protein CBG07423. (511 aa)
npr-14Protein CBR-NPR-14; Belongs to the G-protein coupled receptor 1 family. (287 aa)
dop-4Protein CBR-DOP-4. (509 aa)
ncs-3Protein CBR-NCS-3. (174 aa)
arr-1Protein CBR-ARR-1. (450 aa)
egl-4cGMP-dependent protein kinase egl-4; Promotes chemoreceptor gene expression in response to increased cGMP levels by antagonizing the gene repression functions of the class II HDAC hda-4 and the mef-2 transcription factor. Regulates gene expression via recruitment of a histone deacetylase complex containing hda-2, saeg-1 and saeg-2. Represses body size and lifespan through the dbl-1 and insulin pathways, respectively. May also signal through daf-3 and/or daf-5. Role in egg-laying, dauer formation and motility. Regulates behavioral responses to various chemosensory stimuli in sensory neu [...] (749 aa)
ntr-1Protein CBG08710; Belongs to the G-protein coupled receptor 1 family. (327 aa)
CBG08997Protein CBG08997. (503 aa)
acy-3Protein CBR-ACY-3. (1243 aa)
nhr-47Protein CBR-NHR-47. (585 aa)
glb-5Protein CBR-GLB-5; Belongs to the globin family. (399 aa)
acy-4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1000 aa)
acy-2Protein CBR-ACY-2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1132 aa)
gpa-17Protein CBR-GPA-17. (431 aa)
Cbr-gpr-2Protein CBR-GPR-2. (532 aa)
dat-1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (622 aa)
npr-15Protein CBR-NPR-15; Belongs to the G-protein coupled receptor 1 family. (331 aa)
Cbr-rgs-4Protein CBR-RGS-4. (191 aa)
tyra-2Protein CBR-TYRA-2; Belongs to the G-protein coupled receptor 1 family. (460 aa)
CBG11217Protein CBG11217. (355 aa)
cng-1Protein CBR-CNG-1. (682 aa)
gpb-2Protein CBR-GPB-2. (370 aa)
CBG12105Protein CBG12105. (131 aa)
CBG12208Protein CBG12208. (438 aa)
tax-2Protein CBR-TAX-2. (810 aa)
CBG12846Protein CBG12846. (353 aa)
ckr-1Protein CBR-CKR-1; Belongs to the G-protein coupled receptor 1 family. (425 aa)
ser-3Protein CBR-SER-3; Belongs to the G-protein coupled receptor 1 family. (620 aa)
lgc-55Protein CBR-LGC-55; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (538 aa)
pde-4Phosphodiesterase. (785 aa)
npr-31Protein CBG13074; Belongs to the G-protein coupled receptor 1 family. (406 aa)
CBG13879Protein CBG13879. (72 aa)
gcy-37Protein CBR-GCY-37; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (993 aa)
rgs-7Protein CBR-RGS-7. (892 aa)
CBG14305cAMP-dependent protein kinase, catalytic subunit-like. (385 aa)
dop-1Protein CBR-DOP-1; Belongs to the G-protein coupled receptor 1 family. (459 aa)
nmur-3Protein CBR-NMUR-3; Belongs to the G-protein coupled receptor 1 family. (471 aa)
ntc-1Protein CBG14557. (105 aa)
tyra-3Protein CBR-TYRA-3; Belongs to the G-protein coupled receptor 1 family. (592 aa)
rgs-6Protein CBR-RGS-6. (750 aa)
gnrr-4Protein CBR-GNRR-4. (531 aa)
kin-2Protein CBR-KIN-2. (366 aa)
ckr-2Protein CBR-CKR-2; Belongs to the G-protein coupled receptor 1 family. (602 aa)
ser-4Protein CBR-SER-4; Belongs to the G-protein coupled receptor 1 family. (446 aa)
grk-2Protein CBR-GRK-2. (377 aa)
pkg-2Protein CBR-PKG-2. (616 aa)
npr-18Protein CBR-NPR-18; Belongs to the G-protein coupled receptor 1 family. (464 aa)
npr-21Protein CBG15954. (357 aa)
CBG15937Protein CBG15937. (651 aa)
ser-1Protein CBR-SER-1; Belongs to the G-protein coupled receptor 1 family. (683 aa)
cng-2Protein CBG16807. (814 aa)
gcy-9Guanylate cyclase. (1156 aa)
npr-9Protein CBR-NPR-9; Belongs to the G-protein coupled receptor 1 family. (383 aa)
acy-1Protein CBR-ACY-1. (1287 aa)
CBG18556Protein CBG18556. (224 aa)
mod-1Protein CBR-MOD-1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (490 aa)
dop-2Protein CBR-DOP-2; Belongs to the G-protein coupled receptor 1 family. (852 aa)
CBG19453Protein CBG19453. (621 aa)
gcy-21Guanylate cyclase. (1193 aa)
CBG19820Protein CBG19820. (173 aa)
kin-1cAMP-dependent protein kinase catalytic subunit; Essential for larval development. Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons. Plays a role in the control of oocyte meiotic maturation by gonadal sheath cells. May play a role in the regulation of neuromuscular junctions. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. cAMP subfamily. (374 aa)
gpa-18Protein CBR-GPA-18. (295 aa)
gcy-35Protein CBR-GCY-35. (451 aa)
CBG20391Protein CBG20391. (337 aa)
CBG20392Protein CBG20392; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (273 aa)
CBG20633Protein CBG20633. (370 aa)
CBG20722Protein CBG20722. (176 aa)
CBG20723Protein CBG20723. (160 aa)
CBG20724Protein CBG20724. (162 aa)
CBG20725Protein CBG20725. (188 aa)
CBG25106Protein CBG25106. (639 aa)
ador-1Protein CBG21888. (299 aa)
gpa-11Protein CBR-GPA-11. (488 aa)
gsa-1Protein CBR-GSA-1. (326 aa)
nlp-12Protein CBR-NLP-12. (77 aa)
egl-30Protein CBR-EGL-30. (388 aa)
CBG22517Protein CBG22517. (661 aa)
npr-28Protein CBG22750. (512 aa)
npr-17Protein CBR-NPR-17; Belongs to the G-protein coupled receptor 1 family. (381 aa)
egl-10Protein CBR-EGL-10. (549 aa)
gcy-33Protein CBR-GCY-33; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (948 aa)
daf-11Guanylate cyclase. (1277 aa)
dop-5Protein CBR-DOP-5; Belongs to the G-protein coupled receptor 1 family. (757 aa)
npr-25Protein CBG23177; Belongs to the G-protein coupled receptor 1 family. (378 aa)
CBG25427Protein CBG25427. (69 aa)
CBG25672Protein CBG25672. (72 aa)
gpc-2Protein CBR-GPC-2. (62 aa)
gpc-1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (62 aa)
gpa-6Guanine nucleotide-binding protein alpha-6 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. (365 aa)
gpa-14Guanine nucleotide-binding protein alpha-14 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. (408 aa)
gpa-13Guanine nucleotide-binding protein alpha-13 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. (349 aa)
gpa-10Guanine nucleotide-binding protein alpha-10 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. (362 aa)
gpa-1Guanine nucleotide-binding protein alpha-1 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(q) subfamily. (357 aa)
gpa-3Guanine nucleotide-binding protein alpha-3 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Promotes transcription of 3',5'-cyclic phosphodiesterases pde- 1 and pde-5, leading to reduced cGMP levels in sensory neurons. This causes suppression of insulin production and signaling which leads to increased daf-16 activity and contributes to increased adult lifespan and resistance to oxidative stress. In addition, by reducing cGMP levels, inhibits TGF-beta signaling pathways. Involved in behaviora [...] (354 aa)
gpa-16Guanine nucleotide-binding protein alpha-16 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. In the 1-cell embryo, probably together with goa-1, controls nuclear rotation and spindle elongation during mitosis. During the first embryonic cell divisons, plays a role in gpr-1/2 cortical localization and in the proper orientation of EMS blastomere mitotic spindle; Belongs to the G-alpha family. (354 aa)
gpa-12Guanine nucleotide-binding protein alpha-12 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. May play a role in resistance to fungal infection in the epidermis by regulating the up-regulation of several antimicrobial peptides of the NLP and CNC families. Upstream of plc-3, egl-8, tpa-1 and the p38-like pathway, required for the expression of antimicrobial peptide nlp-29 in the epidermis in response to fungal infection or physical injury; Belongs to the G-alpha family. (355 aa)
gpa-5Guanine nucleotide-binding protein alpha-5 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. (385 aa)
ric-8Synembryn; Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins independently of G-protein coupled receptors. Acts by exchanging bound GDP for free GTP. Also able to activate the G(s)-alpha in synaptic signaling network. Plays a key role in asymmetric spindle positioning, a step for asymmetric cell division that generates cell diversity during development by activating G(i) alpha protein goa-1 and gpa-16 independently of G-protein coupled receptors (By similarity); Belongs to the synembryn family. (567 aa)
gpa-4Guanine nucleotide-binding protein alpha-4 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(i/o/t/z) subfamily. (359 aa)
gpa-15Guanine nucleotide-binding protein alpha-15 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. (356 aa)
dop-3Dopamine receptor 3; Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. In terms of antagonist responses, would be classed with the D2-like dopamine receptor group. Mediates the effect of dopamine on the inhibition of locomotion. Acts as an antagonist of dop-1 (By similarity). (604 aa)
gpa-8Guanine nucleotide-binding protein alpha-8 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. (364 aa)
gpa-7Guanine nucleotide-binding protein alpha-7 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(i/o/t/z) subfamily. (352 aa)
gpb-1Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces. (340 aa)
grk-1G protein-coupled receptor kinase 1; Specifically phosphorylates the activated forms of G protein- coupled receptors; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (640 aa)
odr-3Guanine nucleotide-binding protein alpha-17 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. This specific G-alpha subunit plays an important role in olfaction and in cilia morphogenesis. Involved in chemotactic responses to attractants diacetyl, pyrazine, 2,4,5-trimethylthiazole, benzaldehyde, isoamyl alcohol, butanone and 2,3-pentanedione. Displays a redundant function with gpa-3 in chemotactic responses. Involved in avoidance responses to copper, sodium dodecyl sulfate and linoleic acid. I [...] (356 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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