STRINGSTRING
drn-1 drn-1 pxf-1 pxf-1 mek-2 mek-2 let-60 let-60 rap-3 rap-3 lip-1 lip-1 CBG07097 CBG07097 CBG08006 CBG08006 epac-1 epac-1 CBG12765 CBG12765 gap-1 gap-1 rgl-1 rgl-1 ral-1 ral-1 ksr-2 ksr-2 pkc-2 pkc-2 CBG16121 CBG16121 gap-2 gap-2 ras-2 ras-2 rgef-1 rgef-1 soc-2 soc-2 ras-1 ras-1 CBG21094 CBG21094 mpk-1 mpk-1 rap-1 rap-1 gap-3 gap-3 rga-5 rga-5 ksr-1 ksr-1 lin-45 lin-45
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
drn-1Protein CBR-DRN-1. (310 aa)
pxf-1Protein CBR-PXF-1. (1469 aa)
mek-2Protein CBR-MEK-2; Belongs to the protein kinase superfamily. (387 aa)
let-60Protein CBR-LET-60. (184 aa)
rap-3Protein CBR-RAP-3. (99 aa)
lip-1Protein CBR-LIP-1. (376 aa)
CBG07097Protein CBG07097. (736 aa)
CBG08006Protein CBG08006. (468 aa)
epac-1Protein CBR-EPAC-1. (1101 aa)
CBG12765Protein CBG12765. (713 aa)
gap-1Protein CBR-GAP-1. (1265 aa)
rgl-1Protein CBR-RGL-1. (865 aa)
ral-1Protein CBR-RAL-1. (213 aa)
ksr-2Protein CBR-KSR-2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (589 aa)
pkc-2Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (941 aa)
CBG16121Protein CBG16121. (210 aa)
gap-2Protein CBR-GAP-2. (824 aa)
ras-2Protein CBR-RAS-2. (211 aa)
rgef-1Protein CBR-RGEF-1. (676 aa)
soc-2Leucine-rich repeat protein soc-2; Acts as a Ras effector and participates in MAPK pathway activation. Probably acts as a regulatory subunit of protein phosphatase that specifically dephosphorylates Raf kinase and stimulates Raf activity at specialized signaling complexes upon Ras activation. Required for vulval development. Involved in fluid homeostasis. Plays a role in nicotinic acetylcholine receptor (nAChR)- mediated sensitivity to nicotine; Belongs to the SHOC2 family. (559 aa)
ras-1Protein CBR-RAS-1. (211 aa)
CBG21094Protein CBG21094. (344 aa)
mpk-1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
rap-1Protein CBR-RAP-1. (188 aa)
gap-3Protein CBG22075. (960 aa)
rga-5Protein CBR-RGA-5. (1327 aa)
ksr-1Protein CBR-KSR-1. (812 aa)
lin-45Raf homolog serine/threonine-protein kinase; Protein kinase that participates in the induction of vulva and has a role in fertility and viability. Acts downstream of the Ras protein let-60. Required for progression of developing oocytes through the pachytene stage. Positively regulates lifespan upstream of mek-2 and mpk-1. (811 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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