(25 nodes) Stress-activated MAPK cascade, and NOD1/2 Signaling Pathway network (Caenorhabditis briggsae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CBG00447	Protein CBG00447. (388 aa)
	pmk-1	Mitogen-activated protein kinase. (377 aa)
	pmk-2	Mitogen-activated protein kinase. (392 aa)
	pmk-3	Mitogen-activated protein kinase. (466 aa)
	mkk-4	Protein CBR-MKK-4; Belongs to the protein kinase superfamily. (363 aa)
	CBG03271	Protein CBG03271. (197 aa)
	vhp-1	Protein CBR-VHP-1. (672 aa)
	mom-4	Mitogen-activated protein kinase kinase kinase mom-4; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Stimulates the wrm-1/lit-1-dependent phosphorylation of pop-1 and plays a role in the initial nuclear accumulation of wrm-1 (By similarity). (545 aa)
	jnk-1	Mitogen-activated protein kinase. (464 aa)
	tap-1	Protein CBR-TAP-1. (389 aa)
	rskn-2	Ribosomal protein S6 kinase. (772 aa)
	CBG08594	Protein CBG08594. (389 aa)
	fos-1	Protein CBR-FOS-1. (412 aa)
	kgb-1	Mitogen-activated protein kinase. (382 aa)
	CBG14588	Protein CBG14588. (689 aa)
	jkk-1	Protein CBR-JKK-1. (435 aa)
	CBG14677	Protein CBG14677. (358 aa)
	CBG14753	Protein CBG14753. (173 aa)
	zak-1	Protein CBR-ZAK-1. (769 aa)
	mek-1	Protein CBR-MEK-1. (463 aa)
	sek-1	Protein CBR-SEK-1; Belongs to the protein kinase superfamily. (352 aa)
	atf-7	Protein CBR-ATF-7. (519 aa)
	CBG21256	Protein CBG21256. (378 aa)
	CBG26046	Protein CBG26046. (167 aa)
	jun-1	Protein CBG03270, isoform a. (323 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG00447	CBG03271	A8WN41	A8WSE7	Protein CBG00447.	Protein CBG03271.	0.811
CBG00447	CBG08594	A8WN41	A8X717	Protein CBG00447.	Protein CBG08594.	0.579
CBG00447	CBG14588	A8WN41	A8XK90	Protein CBG00447.	Protein CBG14588.	0.825
CBG00447	CBG14677	A8WN41	A8XKF5	Protein CBG00447.	Protein CBG14677.	0.579
CBG00447	CBG14753	A8WN41	A8XKL4	Protein CBG00447.	Protein CBG14753.	0.519
CBG00447	atf-7	A8WN41	A8XSX6	Protein CBG00447.	Protein CBR-ATF-7.	0.632
CBG00447	fos-1	A8WN41	A8X9H5	Protein CBG00447.	Protein CBR-FOS-1.	0.637
CBG00447	jkk-1	A8WN41	A8XKF4	Protein CBG00447.	Protein CBR-JKK-1.	0.797
CBG00447	jun-1	A8WN41	H8WH96	Protein CBG00447.	Protein CBG03270, isoform a.	0.811
CBG00447	mek-1	A8WN41	A8XPM7	Protein CBG00447.	Protein CBR-MEK-1.	0.790
CBG00447	mkk-4	A8WN41	A8WRM6	Protein CBG00447.	Protein CBR-MKK-4; Belongs to the protein kinase superfamily.	0.822
CBG00447	mom-4	A8WN41	A8WWX1	Protein CBG00447.	Mitogen-activated protein kinase kinase kinase mom-4; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Stimulates the wrm-1/lit-1-dependent phosphorylation of pop-1 and plays a role in the initial nuclear accumulation of wrm-1 (By similarity).	0.679
CBG00447	pmk-1	A8WN41	A8WRD7	Protein CBG00447.	Mitogen-activated protein kinase.	0.445
CBG00447	pmk-2	A8WN41	A8WRD8	Protein CBG00447.	Mitogen-activated protein kinase.	0.447
CBG00447	pmk-3	A8WN41	A8WRD9	Protein CBG00447.	Mitogen-activated protein kinase.	0.471
CBG00447	sek-1	A8WN41	A8XPU4	Protein CBG00447.	Protein CBR-SEK-1; Belongs to the protein kinase superfamily.	0.562
CBG00447	vhp-1	A8WN41	A8WUH4	Protein CBG00447.	Protein CBR-VHP-1.	0.814
CBG00447	zak-1	A8WN41	A8XPG3	Protein CBG00447.	Protein CBR-ZAK-1.	0.481
CBG03271	CBG00447	A8WSE7	A8WN41	Protein CBG03271.	Protein CBG00447.	0.811
CBG03271	CBG21256	A8WSE7	A8XZP6	Protein CBG03271.	Protein CBG21256.	0.745