(63 nodes) Neuron projection guidance, and Immunoglobulin network (Caenorhabditis briggsae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	madd-2	Protein CBR-TRIM-9. (768 aa)
	syg-1	Protein CBR-SYG-1. (746 aa)
	ptp-3	Protein CBR-PTP-3. (1462 aa)
	unc-130	Protein CBR-UNC-130. (332 aa)
	zig-10	Protein CBG02647. (320 aa)
	lect-2	Protein CBG02500. (471 aa)
	CBG02348	Tyrosine-protein kinase. (861 aa)
	lad-2	Protein CBR-LAD-2. (1216 aa)
	dma-1	Protein CBR-DMA-1. (582 aa)
	itx-1	Protein CBR-ITX-1. (1634 aa)
	rig-5	Protein CBR-RIG-5. (409 aa)
	zig-1	Protein CBR-ZIG-1. (265 aa)
	efn-2	Protein CBR-EFN-2; Belongs to the ephrin family. (219 aa)
	seu-1	Protein CBR-SEU-1. (638 aa)
	mnr-1	Protein CBG05639. (506 aa)
	nlr-1	Protein CBR-NLR-1. (1206 aa)
	catp-8	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1219 aa)
	slt-1	Protein CBR-SLT-1. (1376 aa)
	syg-2	Protein CBR-SYG-2. (1270 aa)
	efn-3	Protein CBR-EFN-3; Belongs to the ephrin family. (200 aa)
	igcm-1	Protein CBR-IGCM-1. (1145 aa)
	ncam-1	Protein CBR-NCAM-1. (965 aa)
	mig-21	Protein CBR-MIG-21. (297 aa)
	Cbr-ttn-1	Protein CBR-TTN-1. (2897 aa)
	vab-2	Protein CBR-VAB-2; Belongs to the ephrin family. (242 aa)
	acr-2	Protein CBR-ACR-2. (577 aa)
	unc-6	Protein CBR-UNC-6. (621 aa)
	tab-1	Protein CBR-TAB-1. (192 aa)
	smp-2	Protein CBR-SMP-2; Belongs to the semaphorin family. (689 aa)
	unc-73	Protein CBR-UNC-73. (1618 aa)
	nab-1	Protein CBR-NAB-1. (742 aa)
	tiam-1	Protein CBR-CGEF-2. (610 aa)
	vab-1	Protein CBR-VAB-1. (1118 aa)
	plx-1	Protein CBR-PLX-1. (1959 aa)
	sax-3	Protein CBR-SAX-3. (1295 aa)
	CBG14574	Protein CBG14574. (324 aa)
	zig-9	Protein CBG14880. (281 aa)
	unc-40	Protein CBR-UNC-40. (1407 aa)
	rig-1	Protein CBR-RIG-1. (1170 aa)
	unc-71	Protein CBR-UNC-71. (1045 aa)
	mig-10	Protein CBR-MIG-10. (739 aa)
	zig-3	Protein CBR-ZIG-3. (244 aa)
	unc-115	Protein CBR-UNC-115. (623 aa)
	unc-34	Protein CBR-UNC-34. (459 aa)
	cdh-4	Protein CBR-CDH-4. (4389 aa)
	smp-1	Protein CBR-SMP-1; Belongs to the semaphorin family. (714 aa)
	eva-1	Protein CBR-TAG-271. (467 aa)
	unc-5	Protein CBR-UNC-5. (922 aa)
	zig-8	Protein CBR-ZIG-8. (224 aa)
	rig-6	Protein CBR-RIG-6. (1297 aa)
	elks-1	Protein CBR-ELKS-1. (743 aa)
	unc-129	Protein CBR-UNC-129. (404 aa)
	CBG22265	Protein CBG22265. (450 aa)
	wrk-1	Protein CBR-WRK-1. (576 aa)
	hpo-30	Protein CBR-HPO-30. (201 aa)
	Cbr-sax-7	Protein CBR-SAX-7. (1402 aa)
	unc-53	Protein CBR-UNC-53, isoform a. (1778 aa)
	vab-8	Kinesin-like protein vab-8; Required for posterior migration of cells and axon growth cones during nervous system assembly (By similarity). In PLM neuron, regulates innexin unc-9 gap junction turnover by suppressing unc-9 transport out of the gap junctions (By similarity). Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily. (1069 aa)
	mab-20	Semaphorin-2A; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting and allows the formation of distinct sensory rays. Seems to control cell-cell contact formation through 2 parallel pathways, one involving efn-4 and one involving plx-2 and unc-129. Involved in axon guidance. Probably by binding receptor plx-2, regulates fln-1-mediated remodeling of the actin cytoskeleton and thus [...] (656 aa)
	rig-4	Protein sidekick homolog; Cell adhesion protein; Belongs to the sidekick family. (2322 aa)
	syd-1	Rho GTPase-activating protein syd-1; Probable GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Regulates the localization and assembly of presynaptic components during presynaptic development and is required for specifying the identity of axons during initial polarity acquisition. In these roles it is thought to act cell autonomously downstream of syg-1 and syg-2 and upstream of syd-2, possibly as a positive regulator of the latter. Required for the control of movement, egg-laying and the correct localization of elks-1 (By similarity). (962 aa)
	efn-4	Ephrin-4; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, involved in ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting together with mab-20 and allows the formation of distinct sensory rays. Probably acts as a ligand for lad-2 to regulate axon guidance of several neurons including SDQL, SDQR, SMD and PLN neurons during neurogenesis; Belongs to the ephrin family. (354 aa)
	plx-2	Plexin-2; Involved as a receptor for mab-20/sema-2a in the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, involved in precursor cell sorting and in the formation of distinct sensory rays. Involved in axon guidance of SDQL neurons during neurogenesis. (1773 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG14574	dma-1	A8XK80	A8WW69	Protein CBG14574.	Protein CBR-DMA-1.	0.601
CBG14574	hpo-30	A8XK80	A8Y3W0	Protein CBG14574.	Protein CBR-HPO-30.	0.529
CBG14574	lect-2	A8XK80	A8WU64	Protein CBG14574.	Protein CBG02500.	0.582
CBG14574	mnr-1	A8XK80	A8X0B7	Protein CBG14574.	Protein CBG05639.	0.576
CBG14574	tiam-1	A8XK80	A8XF06	Protein CBG14574.	Protein CBR-CGEF-2.	0.504
CBG22265	rig-4	A8Y1X6	Q60ZN5	Protein CBG22265.	Protein sidekick homolog; Cell adhesion protein; Belongs to the sidekick family.	0.565
Cbr-sax-7	dma-1	H8WH61	A8WW69	Protein CBR-SAX-7.	Protein CBR-DMA-1.	0.937
Cbr-sax-7	hpo-30	H8WH61	A8Y3W0	Protein CBR-SAX-7.	Protein CBR-HPO-30.	0.931
Cbr-sax-7	igcm-1	H8WH61	A8X5T7	Protein CBR-SAX-7.	Protein CBR-IGCM-1.	0.797
Cbr-sax-7	itx-1	H8WH61	A8WW77	Protein CBR-SAX-7.	Protein CBR-ITX-1.	0.642
Cbr-sax-7	lect-2	H8WH61	A8WU64	Protein CBR-SAX-7.	Protein CBG02500.	0.936
Cbr-sax-7	mnr-1	H8WH61	A8X0B7	Protein CBR-SAX-7.	Protein CBG05639.	0.996
Cbr-sax-7	nlr-1	H8WH61	A8X0J8	Protein CBR-SAX-7.	Protein CBR-NLR-1.	0.642
Cbr-sax-7	rig-5	H8WH61	A8WWL0	Protein CBR-SAX-7.	Protein CBR-RIG-5.	0.582
Cbr-sax-7	rig-6	H8WH61	A8XY68	Protein CBR-SAX-7.	Protein CBR-RIG-6.	0.937
Cbr-sax-7	syg-1	H8WH61	A8WRZ1	Protein CBR-SAX-7.	Protein CBR-SYG-1.	0.490
Cbr-sax-7	syg-2	H8WH61	A8X4J5	Protein CBR-SAX-7.	Protein CBR-SYG-2.	0.442
Cbr-sax-7	tiam-1	H8WH61	A8XF06	Protein CBR-SAX-7.	Protein CBR-CGEF-2.	0.738
Cbr-sax-7	unc-5	H8WH61	A8XWR5	Protein CBR-SAX-7.	Protein CBR-UNC-5.	0.514
Cbr-sax-7	unc-6	H8WH61	A8XCA2	Protein CBR-SAX-7.	Protein CBR-UNC-6.	0.637